The Active Ingredient Matrix

The industry standard for modeling botanical stability constraints, clinical formulation synergies, and advanced delivery systems.

2'-Fucosyllactose

PubChem CID: 119538

A human milk oligosaccharide (HMO) that functions as a prebiotic and decoy receptor to modulate gut microbiota composition and inhibit pathogen adhesion to the intestinal epithelium.

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3'-Sialyllactose

PubChem CID: 110661

3'-Sialyllactose is a primary human milk oligosaccharide that functions as a prebiotic substrate for Bifidobacterium species and acts as a decoy receptor for enteric pathogens while providing essential sialic acid for neonatal neurodevelopment and systemic immune modulation.

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5-Hydroxytryptophan (5-HTP)

PubChem CID: 439

5-Hydroxytryptophan serves as the immediate metabolic precursor to serotonin (5-HT), bypassing the rate-limiting step of tryptophan hydroxylase to effectively increase central nervous system indoleamine levels for the management of mood disorders and sleep architecture.

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6'-Sialyllactose

PubChem CID: 439196

6'-Sialyllactose is a major human milk oligosaccharide (HMO) that functions as a prebiotic and decoy receptor to modulate gut microbiota composition and inhibit the adhesion of enteric pathogens to the intestinal epithelium.

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Acacia Fiber (Arabinogalactan)

PubChem CID: 441347

Acacia fiber functions as a highly branched, complex polysaccharide prebiotic that undergoes slow colonic fermentation to selectively increase Bifidobacteria populations and modulate short-chain fatty acid production with high gastrointestinal tolerance.

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Acetyl-L-Carnitine

PubChem CID: 7045

Acetyl-L-Carnitine functions as a high-bioavailability acetyl donor for mitochondrial fatty acid beta-oxidation and the biosynthesis of acetylcholine, facilitating enhanced cellular bioenergetics and neuroprotective signaling.

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Acetyl-L-Carnitine HCl

PubChem CID: 70457

Acetyl-L-carnitine HCl functions as a mitochondrial bioenergetic agent by facilitating the transport of long-chain fatty acids into the mitochondrial matrix for beta-oxidation and providing acetyl groups for the synthesis of acetylcholine, thereby supporting neuroprotection and cognitive function.

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Adhatoda vasica (Vasicine)

PubChem CID: 66749

Adhatoda vasica acts as a potent quinazoline alkaloid-based bronchodilator and mucolytic agent by stimulating ciliary activity and increasing the production of pulmonary surfactant via the activation of alveolar type II cells.

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Albizia julibrissin (Julibroside J1)

PubChem CID: 101232440

Albizia julibrissin functions as a botanical anxiolytic by modulating the GABA-A receptor complex and suppressing the expression of pro-inflammatory markers like TNF-α and IL-6 in the hippocampus.

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Alginate Oligosaccharides (Guluronate/Mannuronate)

PubChem CID: 131751341

Alginate oligosaccharides function as low-molecular-weight marine prebiotics that modulate gut microbiota and exert neuroprotective effects by reducing neuroinflammation and oxidative stress via the gut-liver-brain axis.

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Alginic Acid

PubChem CID: 6852393

Alginic acid is a polyanionic polysaccharide that functions primarily as a raft-forming agent in gastroesophageal reflux treatment by creating a physical pH-neutral barrier atop gastric contents through acid-induced gelation.

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Allium sativum (Allicin)

PubChem CID: 65036

A potent organosulfur compound derived from the enzymatic conversion of alliin by alliinase, primarily utilized for its cardioprotective, antihypertensive, and broad-spectrum antimicrobial activities via the modulation of hydrogen sulfide signaling and inhibition of thiol-dependent enzymes.

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Alpha-Cyclodextrin

PubChem CID: 444913

A cyclic oligosaccharide composed of six glucose units that functions as a molecular encapsulant to improve the solubility, stability, and bioavailability of lipophilic compounds through the formation of inclusion complexes.

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Alpha-Glycerylphosphorylcholine

PubChem CID: 445350

Alpha-glycerylphosphorylcholine is a high-bioavailability cholinergic precursor that crosses the blood-brain barrier to increase acetylcholine levels and facilitate neuronal membrane phospholipid synthesis for cognitive and ergogenic applications.

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Alpha-Linolenic Acid

PubChem CID: 5280934

Alpha-linolenic acid is an essential omega-3 polyunsaturated fatty acid that serves as a primary substrate for the endogenous synthesis of eicosapentaenoic acid and docosahexaenoic acid while modulating systemic inflammation through the competitive inhibition of pro-inflammatory eicosanoid pathways.

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Alpha-Lipoic Acid

PubChem CID: 864

Alpha-lipoic acid acts as a potent amphiphilic antioxidant and essential cofactor for mitochondrial multienzyme complexes, facilitating the regeneration of endogenous antioxidants and modulating insulin signaling pathways.

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Alpha-Tocopherol

PubChem CID: 14985

Alpha-tocopherol acts as a potent lipophilic antioxidant that scavenges lipid peroxyl radicals to maintain cell membrane integrity and prevent oxidative damage to polyunsaturated fatty acids.

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Alpha-amylase

PubChem CID: 16212450

Alpha-amylase is a glycoside hydrolase that catalyzes the hydrolysis of alpha-1,4-glycosidic linkages in starch and glycogen into maltose and dextrins, serving as a critical digestive enzyme for carbohydrate metabolism.

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Alpha-carotene

PubChem CID: 436918

Alpha-carotene is a provitamin A carotenoid that modulates intracellular signaling pathways and exhibits potent antioxidant properties, specifically targeting the inhibition of neoplastic cell proliferation and the reduction of cardiovascular disease risk through its superior radical-scavenging capacity compared to beta-carotene.

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Alpha-galactosidase

PubChem CID: 11966178

A glycoside hydrolase enzyme that catalyzes the hydrolysis of terminal alpha-galactosyl moieties from glycolipids and glycoproteins, primarily utilized to mitigate gastrointestinal distress caused by the fermentation of complex carbohydrates.

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Ammonium Molybdate (Molybdenum)

PubChem CID: 24820

Ammonium molybdate serves as a highly bioavailable source of molybdenum, an essential trace element acting as a critical cofactor for metalloenzymes including sulfite oxidase, xanthine oxidase, and aldehyde oxidase involved in sulfur metabolism and purine catabolism.

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Andrographis paniculata (Andrographolide)

PubChem CID: 5318517

A diterpene lactone that exerts potent anti-inflammatory and immunomodulatory effects primarily through the inhibition of NF-κB signaling and reduction of pro-inflammatory cytokine expression.

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Andrographis paniculata (Andrographolide)

PubChem CID: 5318517

Andrographolide is a diterpene lactone that exerts potent anti-inflammatory and immunomodulatory effects by inhibiting NF-κB signaling and reducing the production of pro-inflammatory cytokines, primarily targeted at mitigating upper respiratory tract infections.

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Andrographis paniculata (Andrographolide)

PubChem CID: 5318517

Andrographis paniculata functions as a potent immunomodulator and anti-inflammatory agent by inhibiting NF-κB activation and modulating pro-inflammatory cytokine expression, primarily indicated for upper respiratory tract infections and systemic inflammation.

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Angelica sinensis (Ligustilide)

PubChem CID: 5362922

Angelica sinensis, standardized for the phthalide ligustilide, functions as a potent vasodilator and anti-inflammatory agent primarily utilized for modulating gynecological health and improving microcirculation via smooth muscle relaxation.

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Apigenin

PubChem CID: 5280443

Apigenin is a bioactive trihydroxyflavone that functions as a potent GABA-A receptor ligand and CD38 inhibitor, primarily utilized for its anxiolytic, neuroprotective, and NAD+ boosting properties.

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Arabinoxylan (Arabinoxylan)

PubChem CID: 131752423

Arabinoxylan is a hemicellulosic polysaccharide that functions as a potent immunomodulator by enhancing Natural Killer (NK) cell activity and modulating cytokine production while serving as a prebiotic fiber for gut microbiome optimization.

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Arachidonic Acid

PubChem CID: 444899

Arachidonic acid is a polyunsaturated omega-6 fatty acid that serves as a critical biosynthetic precursor to eicosanoids, modulating inflammatory signaling pathways and muscle protein synthesis through the cyclooxygenase and lipoxygenase enzymatic cascades.

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Arctium lappa (Arctiin)

PubChem CID: 115098

Arctiin, a lignan glycoside derived from Arctium lappa, functions as a potent anti-inflammatory and antiproliferative agent by modulating the NF-κB and MAP kinase signaling pathways while exhibiting significant antioxidant capacity through the scavenging of reactive oxygen species.

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Artemisia annua (Artemisinin)

PubChem CID: 68827

Artemisinin is a sesquiterpene lactone characterized by an essential endoperoxide bridge that mediates potent antimalarial and selective antineoplastic activity through the iron-dependent generation of cytotoxic free radicals and subsequent alkylation of heme-containing proteins.

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Artichoke Leaf Extract (Cynarin)

PubChem CID: 5281767

Artichoke leaf extract standardized to cynarin functions as a potent choleretic and hepatoprotective agent by stimulating bile acid secretion and inhibiting HMG-CoA reductase to modulate lipid metabolism.

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Ascorbic Acid

PubChem CID: 5280343

Ascorbic acid functions as a potent water-soluble antioxidant and essential cofactor for prolyl and lysyl hydroxylases, facilitating collagen biosynthesis and modulating redox-sensitive signaling pathways within the immune system.

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Ashwagandha (Withaferin A)

PubChem CID: 265237

Ashwagandha functions as a potent adaptogen by modulating the hypothalamic-pituitary-adrenal (HPA) axis and exerting GABAergic mimetic activity to reduce serum cortisol and systemic oxidative stress.

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Ashwagandha Extract (Withaferin A)

PubChem CID: 265237

Ashwagandha extract functions as a potent adaptogen by modulating the hypothalamic-pituitary-adrenal (HPA) axis and exerting neuroprotective effects through the regulation of GABAergic signaling and cortisol secretion.

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Asparagus racemosus (Shatavarin IV)

PubChem CID: 161485

Asparagus racemosus functions as a potent galactagogue and adaptogen by modulating the hypothalamic-pituitary-adrenal axis and exerting phytoestrogenic activity via steroidal saponins that competitively bind to estrogen receptors.

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Astragalin (Kaempferol-3-O-glucoside)

PubChem CID: 5282102

A flavonoid glycoside primarily recognized for its potent anti-inflammatory, antioxidant, and anti-allergic properties mediated through the inhibition of NF-κB and MAPK signaling pathways.

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Astragalus Root (Astragaloside IV)

PubChem CID: 13943297

Astragalus membranaceus functions as a potent immunomodulator and telomerase activator, primarily through the upregulation of T-cell proliferation and the attenuation of pro-inflammatory cytokines via the NF-κB signaling pathway.

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Astragalus membranaceus (Astragaloside IV)

PubChem CID: 13943297

Astragaloside IV acts as a potent cycloastragenol precursor and telomerase activator, exerting cytoprotective effects through the modulation of the PI3K/Akt/mTOR signaling pathway and reduction of oxidative stress-induced senescence.

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Atractylodes macrocephala (Atractylenolide I)

PubChem CID: 5320935

Atractylenolide I is a bioactive sesquiterpene lactone that exerts potent anti-inflammatory and gastroprotective effects primarily through the modulation of the TLR4/NF-κB signaling pathway and inhibition of pro-inflammatory cytokines.

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Bacopa Monnieri (Bacoside A3)

PubChem CID: 11252118

Bacopa monnieri functions as a nootropic adaptogen by modulating acetylcholinesterase activity and upregulating brain-derived neurotrophic factor (BDNF) to enhance dendritic branching and synaptic plasticity in the hippocampus.

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Bacopa monnieri (Bacoside A)

PubChem CID: 11252133

Bacopa monnieri acts as a neuroprotective adaptogen that enhances synaptic communication by upregulating protein kinase activity and increasing dendritic branching in the hippocampus.

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Banaba Leaf Extract (Corosolic Acid)

PubChem CID: 69287

Banaba leaf extract, standardized to corosolic acid, functions as a potent glucose-lowering agent by enhancing GLUT4 translocation and inhibiting alpha-glucosidase activity to improve insulin sensitivity and glycemic control.

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Beetroot Extract (Inorganic Nitrate)

PubChem CID: 24295

Beetroot extract functions as a concentrated source of inorganic nitrates that undergo enterosalivary reduction to nitrite and subsequently nitric oxide, enhancing mitochondrial efficiency and hemodynamics via vasodilation.

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Berberine Hydrochloride (Berberine)

PubChem CID: 12456

Berberine HCL functions as a potent AMPK activator that modulates glucose and lipid metabolism by enhancing insulin sensitivity and downregulating hepatic gluconeogenesis.

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Berberis aristata (Berberine)

PubChem CID: 2353

Berberine functions as a potent adenosine monophosphate-activated protein kinase (AMPK) agonist that regulates systemic glucose homeostasis and lipid metabolism by enhancing GLUT4 translocation and suppressing hepatic gluconeogenesis.

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Beta-Alanine

PubChem CID: 239

Beta-alanine serves as the rate-limiting precursor to carnosine synthesis, functioning as a critical intracellular proton buffer to mitigate exercise-induced acidosis and enhance high-intensity glycolytic performance.

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Beta-Cyclodextrin

PubChem CID: 444041

A cyclic oligosaccharide composed of seven glucopyranose units that functions as a molecular chelator to enhance the solubility, stability, and bioavailability of lipophilic guest molecules through inclusion complex formation.

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Beta-Glucan (Beta-1,3/1,6-D-Glucan)

PubChem CID: 439261

Beta-glucans are complex polysaccharides that function as biological response modifiers by binding to Dectin-1 receptors on macrophages and neutrophils to prime innate immune responses and enhance pathogen surveillance.

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Beta-Sitosterol

PubChem CID: 222284

Beta-sitosterol is a phytosterol that competitively inhibits intestinal cholesterol absorption and modulates 5-alpha-reductase activity to support prostate health and lipid metabolism.

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Beta-carotene

PubChem CID: 5280489

A lipophilic tetraterpenoid provitamin A carotenoid that functions as a potent antioxidant and precursor to retinol, primarily utilized for ocular health, photoprotection, and immune modulation.

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Beta-cryptoxanthin

PubChem CID: 5281235

Beta-cryptoxanthin is a provitamin A carotenoid and potent antioxidant that modulates osteoblast activity and suppresses osteoclastogenesis via the RANKL/RANK signaling pathway, primarily targeting bone density and respiratory health.

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Beta-glucanase

PubChem CID: 131751341

A hydrolase enzyme that catalyzes the breakdown of beta-glucans into glucose units, primarily used to reduce intestinal viscosity and improve nutrient bioavailability in high-fiber diets.

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Bilberry Fruit Extract (Cyanidin-3-glucoside)

PubChem CID: 441667

Bilberry extract exerts potent vasoprotective and antioxidant effects primarily through the modulation of rhodopsin regeneration and the inhibition of inflammatory cytokines in the retinal pigment epithelium.

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Biotin (Vitamin B7)

PubChem CID: 171

Biotin functions as a covalently bound prosthetic group for carboxylase enzymes, facilitating essential carboxylation reactions in fatty acid synthesis, gluconeogenesis, and amino acid catabolism to support metabolic homeostasis and structural protein synthesis.

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Bitter Melon Extract (Charantin)

PubChem CID: 10251

Bitter melon extract standardized to charantin functions as a potent hypoglycemic agent by enhancing insulin secretion, improving glucose uptake via GLUT4 translocation, and inhibiting hepatic gluconeogenesis.

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Blackcurrant Extract (Delphinidin-3-rutinoside)

PubChem CID: 44256722

Delphinidin-3-rutinoside is a potent anthocyanin glycoside that modulates rhodopsin regeneration and inhibits vascular endothelial growth factor (VEGF) expression to support ocular microcirculation and retinal health.

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Boerhavia diffusa (Punarnavine)

PubChem CID: 101616

Boerhavia diffusa functions as a potent nephroprotective and diuretic agent by modulating renal hemodynamics and inhibiting pro-inflammatory cytokines through its primary quinolizidine alkaloid, punarnavine.

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Boron Citrate

PubChem CID: 11119511

Boron citrate is a bioavailable chelated form of boron that modulates steroid hormone metabolism, specifically increasing free testosterone levels and supporting bone mineral density through the regulation of calcium and magnesium excretion.

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Boron Glycinate

PubChem CID: 131752321

Boron glycinate is a chelated mineral complex designed to enhance the bioavailability of elemental boron, primarily functioning as a metabolic regulator of steroid hormones and a structural stabilizer for the bone matrix through the modulation of calcium and magnesium kinetics.

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Boswellia Serrata (AKBA)

PubChem CID: 11386458

Boswellia serrata extract functions as a potent, non-redox inhibitor of 5-lipoxygenase (5-LOX), effectively downregulating leukotriene biosynthesis to manage chronic inflammatory pathologies such as osteoarthritis and asthma.

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Boswellia Serrata (Acetyl-11-keto-beta-boswellic acid)

PubChem CID: 11386458

AKBA is a potent pentacyclic triterpenoid that selectively inhibits 5-lipoxygenase (5-LOX), thereby suppressing the biosynthesis of pro-inflammatory leukotrienes in chronic inflammatory conditions like osteoarthritis and asthma.

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Boswellia serrata (3-O-acetyl-11-keto-beta-boswellic acid)

PubChem CID: 11386456

A potent pentacyclic triterpenoid extract that selectively inhibits 5-lipoxygenase (5-LOX) to modulate leukotriene synthesis for the management of chronic inflammatory conditions like osteoarthritis and asthma.

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Brassica oleracea italica (Glucoraphanin)

PubChem CID: 9548622

Glucoraphanin serves as a stable glucosinolate precursor that, upon enzymatic hydrolysis by myrosinase, yields sulforaphane to induce Nrf2-mediated phase II detoxification enzymes and provide potent cytoprotective effects.

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Brassicasterol

PubChem CID: 5283653

A phytosterol primarily derived from rapeseed and marine algae that modulates lipid metabolism and exhibits neuroprotective potential through the inhibition of beta-amyloid aggregation.

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Broccoli Extract (Sulforaphane)

PubChem CID: 5350

Sulforaphane is a potent electrophilic isothiocyanate that induces the Nrf2-mediated antioxidant response element (ARE) pathway, facilitating phase II detoxification enzyme expression and providing robust cytoprotection against oxidative stress and xenobiotic insult.

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Bromelain (Stem Bromelain)

PubChem CID: 16131497

A proteolytic enzyme complex derived from Ananas comosus that exerts systemic anti-inflammatory and fibrinolytic effects by modulating the arachidonic acid cascade and cleaving cell surface signaling molecules.

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Brown Seaweed (Fucoxanthin)

PubChem CID: 5281239

Fucoxanthin is a marine carotenoid that modulates metabolic rate via the upregulation of uncoupling protein 1 (UCP1) in white adipose tissue and exhibits potent antioxidant activity through its unique allenic bond and 5,6-monoepoxide structure.

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Bupleurum chinense (Saikosaponin A)

PubChem CID: 104301

Saikosaponin A is a triterpenoid saponin that modulates the hypothalamic-pituitary-adrenal (HPA) axis and exerts potent anti-inflammatory effects via the inhibition of NF-κB and MAPK signaling pathways.

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Burdock Root (Arctiin)

PubChem CID: 119031

Burdock root extract functions as a potent anti-inflammatory and hepatoprotective agent by modulating the NF-κB signaling pathway and exerting antioxidant effects through its high concentration of lignans and caffeoylquinic acids.

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Calcium Citrate Malate

PubChem CID: 11954168

Calcium Citrate Malate is a highly bioavailable, water-soluble chelated mineral complex designed to optimize intestinal calcium absorption via both paracellular and transcellular pathways while minimizing the risk of nephrolithiasis compared to inorganic carbonates.

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Calcium Fructoborate

PubChem CID: 11953934

Calcium fructoborate is a bioactive sugar-borate ester that modulates systemic inflammatory markers like C-reactive protein and interleukin-6 while supporting joint integrity and steroid hormone metabolism.

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Calcium L-5-Methyltetrahydrofolate

PubChem CID: 23666113

As the primary biologically active diastereoisomer of folate, this compound bypasses the MTHFR rate-limiting enzymatic conversion to directly provide methyl groups for the conversion of homocysteine to methionine and support nucleic acid synthesis.

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Calcium Pantothenate

PubChem CID: 989

Calcium pantothenate serves as a critical precursor to Coenzyme A (CoA), facilitating the acetylation of choline and the oxidative metabolism of carbohydrates, lipids, and amino acids within the mitochondrial matrix.

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Camellia sinensis (Epigallocatechin gallate)

PubChem CID: 65064

A potent catechin polyphenol that modulates cellular signaling pathways, including PI3K/Akt and MAPK, to exert significant antioxidant, anti-inflammatory, and thermogenic effects.

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Campesterol

PubChem CID: 173183

Campesterol is a phytosterol that competitively inhibits intestinal cholesterol absorption by displacing dietary and biliary cholesterol from mixed micelles, thereby modulating lipid metabolism and reducing serum LDL-C levels.

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Canthaxanthin

PubChem CID: 5281227

Canthaxanthin is a keto-carotenoid that functions as a potent antioxidant and photoprotective agent by quenching singlet oxygen and scavenging free radicals, primarily utilized for skin pigmentation and macular health.

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Capric Acid (Decanoic Acid)

PubChem CID: 2969

Capric acid is a medium-chain fatty acid (C10:0) that acts as a non-competitive antagonist of AMPA receptors and a PPARγ agonist, primarily utilized for its ketogenic potential and anticonvulsant properties.

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Caprylic Acid

PubChem CID: 379

A medium-chain saturated fatty acid that functions as a potent antimicrobial agent by disrupting fungal cell membranes and acts as a direct ketogenic substrate for mitochondrial energy metabolism.

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Cascara Sagrada Bark Extract (Cascaroside A)

PubChem CID: 10887612

Cascara sagrada functions as a stimulant laxative by utilizing anthraquinone glycosides that undergo bacterial hydrolysis in the colon to induce peristalsis and increase electrolyte secretion.

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Cat's Claw (Mitraphylline)

PubChem CID: 161245

Mitraphylline is a pentacyclic oxindole alkaloid that modulates the immune response by inhibiting NF-κB signaling and reducing the production of pro-inflammatory cytokines such as TNF-α and IL-6.

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Cat's Claw Extract (Mitraphylline)

PubChem CID: 441972

Cat's Claw extract functions as a potent immunomodulator and anti-inflammatory agent by inhibiting NF-κB activation and modulating cytokine production through its pentacyclic oxindole alkaloids.

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Catalase

PubChem CID: 23675242

Catalase is a high-turnover antioxidant enzyme that facilitates the rapid dismutation of hydrogen peroxide into molecular oxygen and water, mitigating oxidative stress and preventing cellular macromolecular damage.

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Celery Extract (Apigenin)

PubChem CID: 5280443

Apigenin is a bioactive flavone that functions as a competitive antagonist of adenosine A1 receptors and a positive allosteric modulator of GABA-A receptors, providing potent anxiolytic and neuroprotective effects while inhibiting pro-inflammatory cytokines via the NF-κB pathway.

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Cellobiose

PubChem CID: 439178

Cellobiose is a reducing disaccharide derived from cellulose hydrolysis that acts as a non-digestible prebiotic, selectively stimulating the growth of beneficial gut microbiota while modulating systemic glycemic response.

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Cellulase

PubChem CID: 11966249

Cellulase is a multi-enzyme complex that catalyzes the hydrolysis of 1,4-beta-D-glycosidic linkages in cellulose, facilitating the breakdown of plant cell walls to improve nutrient bioavailability and alleviate digestive distress associated with high-fiber diets.

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Centella asiatica (Asiaticoside)

PubChem CID: 119034

Centella asiatica functions as a potent neuroprotective and dermatological agent by modulating TGF-β signaling pathways to enhance collagen synthesis and upregulating antioxidant enzymes to mitigate oxidative stress in neuronal tissues.

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Centella asiatica (Asiaticoside)

PubChem CID: 72239

Centella asiatica functions primarily through its pentacyclic triterpenoid saponins to modulate fibroblast proliferation and collagen synthesis while providing neuroprotective effects via the attenuation of oxidative stress and modulation of the HPA axis.

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Centella asiatica (Asiaticoside)

PubChem CID: 442108

Asiaticoside is a trisaccharide triterpene that modulates collagen synthesis via the TGF-β/Smad pathway and enhances antioxidant enzyme activity to promote wound healing and neuroprotection.

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Centella asiatica (Madecassoside)

PubChem CID: 16124041

Madecassoside is a pentacyclic triterpene glycoside that modulates TGF-β/Smad signaling pathways to enhance collagen synthesis and suppress pro-inflammatory cytokines for accelerated tissue repair.

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Cesium Chloride

PubChem CID: 24293

Cesium chloride is an inorganic alkali metal salt primarily investigated for its ability to induce intracellular alkalization and modulate voltage-gated potassium channels, though its clinical application is severely constrained by its narrow therapeutic index and risk of cardiotoxicity.

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Cetyl Myristoleate

PubChem CID: 5364509

Cetyl myristoleate acts as a unique fatty acid ester that modulates the inflammatory response by inhibiting 5-lipoxygenase and stabilizing lysosomal membranes, primarily utilized for improving joint mobility and mitigating symptoms of osteoarthritis.

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Chaga Mushroom (Betulinic Acid)

PubChem CID: 64971

Chaga mushroom extract functions as a potent immunomodulator and antioxidant by leveraging high concentrations of betulinic acid and chromogenic phenolic complexes to mitigate oxidative stress and regulate cytokine production.

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Chelidonium majus (Chelidonine)

PubChem CID: 91456

Chelidonine acts as a selective inhibitor of acetylcholinesterase and a microtubule-disrupting agent, primarily utilized for its spasmolytic, choleretic, and potential antineoplastic properties in hepatobiliary and gastrointestinal pathologies.

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Chito-oligosaccharides (Chitotriose)

PubChem CID: 123831

Chito-oligosaccharides function as low-molecular-weight bioactive polymers that exert potent anti-inflammatory, antioxidant, and prebiotic effects by modulating the NF-κB signaling pathway and enhancing beneficial gut microbiota populations.

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Chitooligosaccharides (Chitohexaose)

PubChem CID: 123831

Chitooligosaccharides are low-molecular-weight glucosamine polymers that exert potent anti-inflammatory and immunomodulatory effects by downregulating NF-κB pathways and enhancing intestinal epithelial barrier function.

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Chitosan (Poly-D-glucosamine)

PubChem CID: 71853

A linear polysaccharide derived from chitin that functions as a polycationic lipid-binding fiber and mucoadhesive agent, primarily utilized for weight management and controlled-release drug delivery.

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Chlorella Powder (Chlorophyll a)

PubChem CID: 6433164

Chlorella serves as a nutrient-dense bioactive matrix that facilitates heavy metal chelation and immunomodulation through its unique Chlorella Growth Factor (CGF) and high concentration of porphyrin-based chlorophyll.

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Cholecalciferol (Vitamin D3)

PubChem CID: 5280795

Cholecalciferol acts as a secosteroid prohormone that undergoes sequential hepatic and renal hydroxylation to form calcitriol, the active ligand for the vitamin D receptor (VDR) modulating calcium homeostasis and immune-related genomic expression.

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Choline Bitartrate (Choline)

PubChem CID: 10490

Choline bitartrate functions as a cholinergic precursor and methyl donor that facilitates the synthesis of acetylcholine and phosphatidylcholine, thereby supporting cognitive performance, hepatic lipid transport, and systemic homocysteine regulation.

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Chondroitin Sulfate

PubChem CID: 24766

A sulfated glycosaminoglycan that serves as a critical structural component of the extracellular matrix, exerting chondroprotective effects by inhibiting matrix metalloproteinases and promoting the synthesis of endogenous proteoglycans.

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Chondroitin Sulfate Sodium

PubChem CID: 23666333

A sulfated glycosaminoglycan that serves as a critical structural component of the extracellular matrix in articular cartilage, providing mechanical resistance to compression and inhibiting pro-inflammatory enzymatic degradation.

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Chromium Picolinate

PubChem CID: 151932

Chromium picolinate functions as a nutritional insulin sensitizer by upregulating insulin receptor tyrosine kinase activity and promoting GLUT4 translocation for improved glucose homeostasis.

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Chrysin

PubChem CID: 5281607

Chrysin is a naturally occurring flavone that acts as a competitive inhibitor of the aromatase enzyme (CYP19), modulating the conversion of androgens to estrogens while exhibiting anti-inflammatory and antioxidant properties via NF-κB pathway inhibition.

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Cichorium intybus (Cichoric acid)

PubChem CID: 5281764

Cichoric acid is a potent polyphenolic compound that functions as a glucose-sensitizing agent and HIV-1 integrase inhibitor, primarily modulating metabolic pathways through AMPK activation and reducing oxidative stress.

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Cichorium intybus (Esculetin)

PubChem CID: 5281416

Esculetin, a dihydroxycoumarin derivative from Cichorium intybus, exerts potent hepatoprotective and anti-inflammatory effects by modulating the Nrf2/HO-1 signaling pathway and inhibiting xanthine oxidase activity.

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Cinnamon Bark (Cinnamaldehyde)

PubChem CID: 637511

Cinnamon bark extract acts as an insulin mimetic and insulin sensitizer by enhancing glucose transporter type 4 (GLUT4) translocation and inhibiting alpha-glucosidase activity to improve glycemic control and metabolic health.

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Cistanche deserticola (Echinacoside)

PubChem CID: 5281771

Cistanche deserticola functions as a potent neuroprotective and ergogenic agent by modulating the Nrf2/ARE signaling pathway and enhancing steroidogenesis through the upregulation of CYP11A1 and CYP17A1 enzymes.

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Citicoline Sodium

PubChem CID: 23662344

Citicoline-sodium functions as a rate-limiting exogenous precursor for phosphatidylcholine biosynthesis via the Kennedy pathway, facilitating neuronal membrane repair and increasing synaptic acetylcholine concentrations to improve cognitive function.

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Cobaltous Chloride

PubChem CID: 24025

Cobaltous chloride acts as a chemical mimetic of hypoxia by stabilizing hypoxia-inducible factor-1α (HIF-1α) through the inhibition of prolyl hydroxylase domain-containing proteins, thereby stimulating erythropoietin expression and erythropoiesis.

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Codonopsis pilosula (Lobetyolin)

PubChem CID: 11667822

Lobetyolin, a polyacetylene glycoside derived from Codonopsis pilosula, functions as a potent immunomodulator and gastroprotective agent by inhibiting NF-κB activation and promoting gastric mucosal repair.

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Codonopsis pilosula (Syringin)

PubChem CID: 5316861

Codonopsis pilosula acts as an adaptogenic immunomodulator that enhances hematopoietic function and mitigates oxidative stress through the regulation of the PI3K/Akt signaling pathway.

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Coenzyme Q10 (Ubiquinone)

PubChem CID: 5281915

Coenzyme Q10 is a lipophilic benzoquinone that functions as a critical electron carrier in the mitochondrial respiratory chain and a potent membrane antioxidant, primarily utilized for cardiovascular support and mitochondrial bioenergetics.

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Conjugated Linoleic Acid (c9, t11-CLA)

PubChem CID: 5280644

Conjugated Linoleic Acid acts as a dual ligand for PPAR-alpha and PPAR-gamma receptors, modulating lipid metabolism and inhibiting lipoprotein lipase activity to reduce adipocyte volume and improve body composition.

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Convolvulus pluricaulis (Scopolin)

PubChem CID: 5280644

Convolvulus pluricaulis acts as a potent nootropic and anxiolytic by modulating the hypothalamic-pituitary-adrenal axis and increasing acetylcholinesterase inhibition within the hippocampal region.

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Copper Bisglycinate

PubChem CID: 165045

Copper bisglycinate is a highly bioavailable chelated mineral complex that serves as a critical cofactor for lysyl oxidase and superoxide dismutase, facilitating connective tissue integrity and antioxidant defense mechanisms.

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Copper Gluconate

PubChem CID: 15190

Copper gluconate serves as a highly bioavailable chelated mineral source essential for cytochrome c oxidase activity, lysyl oxidase-mediated collagen cross-linking, and superoxide dismutase-driven antioxidant defense.

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Copper Sebacate

PubChem CID: 11954171

Copper Sebacate is a highly bioavailable chelated mineral complex that serves as an essential cofactor for lysyl oxidase and superoxide dismutase, facilitating connective tissue integrity and cellular antioxidant defense.

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Coptis chinensis (Berberine)

PubChem CID: 2353

Coptis chinensis extract, standardized for the isoquinoline alkaloid berberine, functions as a potent AMPK activator and insulin sensitizer, modulating glucose metabolism and lipid homeostasis through the inhibition of mitochondrial respiratory complex I.

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Cordyceps Extract (Cordycepin)

PubChem CID: 14928

Cordyceps extract functions as a potent adenosine analog that modulates cellular ATP production and mitochondrial efficiency while exerting immunomodulatory effects via the activation of macrophages and natural killer cells.

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Cordyceps sinensis (Cordycepin)

PubChem CID: 14928

Cordycepin acts as a nucleoside analogue that modulates cellular bioenergetics via AMPK activation and inhibits polyadenylation-driven mRNA synthesis to exert potent anti-inflammatory and ergogenic effects.

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Corydalis yanhusuo (Tetrahydropalmatine)

PubChem CID: 72301

Corydalis yanhusuo functions primarily as a potent analgesic and sedative through the antagonism of dopamine D2 receptors and the inhibition of acetylcholinesterase by its primary isoquinoline alkaloid, tetrahydropalmatine.

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Cotinus coggygria (Fisetin)

PubChem CID: 5281614

Fisetin is a senolytic flavonol that selectively induces apoptosis in senescent cells via inhibition of the PI3K/AKT/mTOR pathway and modulation of the sirtuin-1 (SIRT1) signaling axis.

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Creatine Monohydrate

PubChem CID: 586

Creatine monohydrate functions as a high-energy phosphate donor to rapidly regenerate adenosine triphosphate (ATP) via the phosphocreatine shuttle, significantly enhancing anaerobic capacity and neuromuscular performance.

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Crocus sativus (Crocin)

PubChem CID: 5281233

Crocus sativus exerts potent neuroprotective and antidepressant effects by modulating NMDA receptor antagonism and inhibiting the reuptake of monoamine neurotransmitters while providing significant antioxidant support for ocular health.

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Curcuma longa (Curcumin)

PubChem CID: 969516

Curcuma longa functions as a potent pleiotropic modulator of the NF-κB and MAPK signaling pathways, exerting systemic anti-inflammatory and antioxidant effects through the inhibition of cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) enzymes.

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Cuscuta chinensis (Kaempferol)

PubChem CID: 5280863

Cuscuta chinensis extract, standardized for the flavonol kaempferol, functions as a potent phytoestrogenic and antioxidant agent that modulates the hypothalamic-pituitary-gonadal axis and inhibits oxidative stress-induced apoptosis in osteoblasts and germ cells.

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Cyanidin-3-glucoside

PubChem CID: 441667

Cyanidin-3-glucoside functions as a potent anthocyanin that modulates glucose metabolism via AMPK activation and enhances vascular function through the upregulation of endothelial nitric oxide synthase (eNOS).

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Cynara scolymus (Cynarin)

PubChem CID: 5281769

Cynarin acts as a potent choleretic and hepatoprotective agent by stimulating bile acid secretion and inhibiting HMG-CoA reductase to modulate lipid metabolism and alleviate dyspeptic symptoms.

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D-Aspartic Acid

PubChem CID: 439197

D-Aspartic acid acts as a physiological NMDA receptor agonist and accumulates in the adenohypophysis and testes, where it upregulates the synthesis of testosterone by increasing the expression of steroidogenic acute regulatory protein and stimulating the release of luteinizing hormone.

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Daidzein

PubChem CID: 5281708

Daidzein is a soy-derived isoflavone that functions as a selective estrogen receptor modulator (SERM) and phytoestrogen, primarily utilized for the management of menopausal symptoms and the preservation of bone mineral density via metabolic conversion to equol.

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Dandelion Root (Taraxasterol)

PubChem CID: 92103

Dandelion root extract functions as a potassium-sparing diuretic and cholagogue, modulating hepatic detoxification pathways and renal fluid excretion through sesquiterpene lactones and triterpenoid activity.

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Desmodium adscendens (Soyasaponin I)

PubChem CID: 122138

Desmodium adscendens functions as a potent hepatoprotective and spasmolytic agent by modulating the arachidonic acid cascade and inhibiting the release of histamine and leukotrienes via its triterpenoid saponin fraction.

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Devil's Claw (Harpagoside)

PubChem CID: 5460071

Harpagoside acts as a potent iridoid glycoside that inhibits the cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) pathways, effectively modulating pro-inflammatory cytokine expression for the management of osteoarthritic pain and systemic inflammation.

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Devil's Claw (Harpagoside)

PubChem CID: 5281542

Harpagoside is a bioactive iridoid glycoside that exerts potent anti-inflammatory and analgesic effects by inhibiting the expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) within the arachidonic acid cascade.

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Dihomo-gamma-linolenic Acid

PubChem CID: 5280581

Dihomo-gamma-linolenic acid (DGLA) is an omega-6 polyunsaturated fatty acid that serves as the immediate precursor to prostaglandin E1 (PGE1), exerting potent anti-inflammatory and anti-aggregatory effects by modulating eicosanoid biosynthesis.

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Docosahexaenoic Acid

PubChem CID: 445580

Docosahexaenoic acid is a long-chain omega-3 polyunsaturated fatty acid that modulates neuronal membrane fluidity and serves as a precursor to specialized pro-resolving mediators like resolvins and protectins to mitigate neuroinflammation.

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Docosapentaenoic Acid

PubChem CID: 5312635

Docosapentaenoic acid (DPA) is a long-chain omega-3 polyunsaturated fatty acid that serves as a metabolic intermediary between EPA and DHA, exerting potent anti-inflammatory and pro-resolving effects via the synthesis of specialized pro-resolving mediators (SPMs).

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Dunaliella salina (Beta-carotene)

PubChem CID: 5280489

Beta-carotene functions as a lipophilic provitamin A carotenoid that undergoes BCO1-mediated oxidative cleavage to retinal, providing critical antioxidant protection against singlet oxygen and supporting systemic epithelial homeostasis.

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Echinacea Purpurea (Cichoric Acid)

PubChem CID: 5281764

Echinacea purpurea functions as an immunomodulator by stimulating phagocytic activity and enhancing cytokine production through the activation of cannabinoid receptor type 2 (CB2) and toll-like receptor pathways.

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Echinacea purpurea (Cichoric acid)

PubChem CID: 5281764

Cichoric acid acts as a potent immunomodulator and hyaluronidase inhibitor, enhancing phagocytosis and stimulating the proliferation of T-lymphocytes to bolster innate and adaptive immune responses.

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Ecklonia cava (Dieckol)

PubChem CID: 10432657

Dieckol is a marine-derived phlorotannin that functions as a potent polyphenol with multi-modal activity, primarily targeting acetylcholinesterase inhibition, SIRT1 activation, and the attenuation of pro-inflammatory cytokines for neuroprotective and metabolic health applications.

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Ecklonia cava (Phlorofucofuroeckol A)

PubChem CID: 11271640

A phlorotannin derived from brown algae that exhibits potent anti-inflammatory, neuroprotective, and anti-diabetic properties through the inhibition of NF-κB signaling and α-glucosidase activity.

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Eckol

PubChem CID: 119213

Eckol is a phlorotannin derivative that exhibits potent antioxidant, anti-inflammatory, and neuroprotective properties by modulating the Nrf2/HO-1 signaling pathway and inhibiting pro-inflammatory cytokines.

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Eclipta alba (Wedelolactone)

PubChem CID: 5281813

Wedelolactone functions as a potent inhibitor of NF-κB signaling and 5-lipoxygenase, exerting significant hepatoprotective and anti-inflammatory effects through the modulation of pro-inflammatory cytokine expression and oxidative stress pathways.

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Eicosapentaenoic Acid

PubChem CID: 446284

Eicosapentaenoic acid is a long-chain omega-3 polyunsaturated fatty acid that functions as a competitive substrate for cyclooxygenase and lipoxygenase enzymes to attenuate pro-inflammatory eicosanoid synthesis and promote cardiovascular and cognitive health.

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Eicosatetraenoic acid

PubChem CID: 5282831

A polyunsaturated omega-3 fatty acid that acts as a dual inhibitor of cyclooxygenase and lipoxygenase pathways to modulate systemic inflammation and support joint health.

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Elderberry Extract (Cyanidin-3-glucoside)

PubChem CID: 441667

Elderberry extract functions primarily through anthocyanin-mediated inhibition of viral entry and replication via neuraminidase blockade while concurrently modulating cytokine expression to enhance innate immune response.

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Eleuthero Root (Eleutheroside B)

PubChem CID: 5316860

Eleuthero root extract functions as a primary adaptogen by modulating the hypothalamic-pituitary-adrenal (HPA) axis and increasing heat shock protein expression to enhance non-specific resistance to physical and environmental stressors.

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Eleutherococcus senticosus (Eleutheroside E)

PubChem CID: 73140

Eleutheroside E acts as a potent adaptogen by modulating the hypothalamic-pituitary-adrenal (HPA) axis and upregulating molecular chaperones like HSP70 to enhance cellular resilience against physical and oxidative stressors.

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Ellagic Acid

PubChem CID: 5281855

Ellagic acid is a polyphenolic antioxidant that exerts potent chemopreventive and anti-inflammatory effects by modulating the NF-κB pathway and inhibiting oxidative stress-induced DNA damage.

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Embelia ribes (Embelin)

PubChem CID: 3218

Embelia ribes functions primarily as a potent anthelmintic and chemopreventive agent by modulating the NF-κB signaling pathway and inhibiting X-linked inhibitor of apoptosis protein (XIAP) to induce apoptosis in compromised cell lines.

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Emblica officinalis (Geraniin)

PubChem CID: 442401

Geraniin, a hydrolyzable dehydroellagitannin derived from Emblica officinalis, functions as a potent antioxidant and hepatoprotective agent by modulating Nrf2 signaling pathways and inhibiting pro-inflammatory cytokine expression.

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Epimedium brevicornum (Icariin)

PubChem CID: 5318997

Icariin functions as a prenylated flavonol glycoside that exerts phosphodiesterase type 5 (PDE5) inhibition and promotes osteogenic differentiation through the activation of the Wnt/beta-catenin signaling pathway.

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Ergothioneine

PubChem CID: 21750

Ergothioneine is a unique sulfur-containing amino acid derivative that functions as a potent cytoprotective antioxidant and mitochondrial protector, utilizing the specific SLC22A4 (OCTN1) transporter for high-affinity cellular uptake and tissue distribution.

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Eschscholzia californica (Protopine)

PubChem CID: 4970

Eschscholzia californica functions as a mild sedative and anxiolytic by modulating GABA-A receptors and inhibiting dopamine beta-hydroxylase, primarily utilized for sleep induction and stress reduction.

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Eucommia ulmoides (Geniposidic acid)

PubChem CID: 443354

Eucommia ulmoides extract, standardized for geniposidic acid, functions as a potent osteoprotective and antihypertensive agent by modulating TGF-β1 signaling and promoting collagen synthesis within the extracellular matrix.

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Fenugreek (4-Hydroxyisoleucine)

PubChem CID: 154910

Trigonella foenum-graecum acts as a glucose-dependent insulinotropic agent and alpha-glucosidase inhibitor, primarily utilized for the management of postprandial glycemic response and the modulation of androgenic lipid metabolism.

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Fenugreek Seed Extract (4-Hydroxyisoleucine)

PubChem CID: 440590

Fenugreek seed extract functions as a glucose-dependent insulinotropic agent by modulating GLUT4 translocation and inhibiting alpha-amylase activity to improve glycemic control and metabolic homeostasis.

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Ferrous Bisglycinate

PubChem CID: 165085

Ferrous bisglycinate is a high-bioavailability amino acid chelate designed to bypass traditional divalent metal transporter-1 competition, providing superior gastrointestinal tolerability and systemic iron replenishment for erythropoiesis.

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Ferulic Acid

PubChem CID: 445858

A potent hydroxycinnamic acid derivative that functions as a free radical scavenger and inhibitor of lipid peroxidation, primarily utilized for its cardioprotective, neuroprotective, and dermatological photoprotective properties.

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Fisetin

PubChem CID: 5281614

Fisetin is a flavonol senolytic that selectively induces apoptosis in senescent cells via inhibition of the PI3K/AKT/mTOR pathway and modulation of the SIRT1/AMPK axis to mitigate age-related systemic inflammation.

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Forsythia suspensa (Phillyrin)

PubChem CID: 98555

Phillyrin is a lignan glycoside that exerts potent anti-inflammatory and antiviral effects by inhibiting the NF-κB and MAPK signaling pathways, primarily utilized in treating respiratory tract infections and systemic inflammation.

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Fructo-oligosaccharides (1-Kestose)

PubChem CID: 439653

Fructo-oligosaccharides function as non-digestible prebiotic fibers that selectively stimulate the proliferation of bifidobacteria and lactobacilli in the colon, thereby modulating the gut-brain axis and enhancing mineral absorption through the production of short-chain fatty acids.

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Fructooligosaccharides (1-Kestose)

PubChem CID: 439531

Fructooligosaccharides function as non-digestible prebiotic fibers that selectively stimulate the proliferation of bifidogenic microflora in the colon, thereby modulating the gut-brain axis and enhancing mineral absorption via acidification of the luminal environment.

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Fucoidan (L-Fucose)

PubChem CID: 129532616

Fucoidan is a complex sulfated polysaccharide derived from brown seaweed that exerts potent immunomodulatory, anti-inflammatory, and anticoagulant effects by inhibiting selectins and modulating the NF-κB signaling pathway.

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Fucosterol

PubChem CID: 5281328

Fucosterol is a marine-derived phytosterol that exerts neuroprotective, anti-diabetic, and anti-inflammatory effects primarily through the modulation of the PI3K/Akt and MAPK signaling pathways.

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Fumaria officinalis (Protopine)

PubChem CID: 4970

Fumaria officinalis functions as an amphicholeretic and spasmolytic agent by modulating biliary secretion and exerting GABAergic effects through its primary isoquinoline alkaloid, protopine.

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Galacto-oligosaccharides (4'-Galactosyl-lactose)

PubChem CID: 123984

Galacto-oligosaccharides function as potent prebiotic fibers that selectively modulate the colonic microbiota, specifically increasing Bifidobacterium populations to enhance intestinal barrier integrity and systemic immune homeostasis.

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Galactooligosaccharides

PubChem CID: 439668

Galactooligosaccharides are prebiotic carbohydrates that selectively stimulate the growth of Bifidobacteria and Lactobacilli in the gastrointestinal tract to modulate the gut-brain axis and enhance mineral absorption.

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Gamma-Linolenic Acid

PubChem CID: 5280934

Gamma-linolenic acid is an omega-6 polyunsaturated fatty acid that serves as the direct precursor to dihomo-gamma-linolenic acid (DGLA), facilitating the biosynthesis of anti-inflammatory series 1 prostaglandins (PGE1) to regulate systemic inflammatory responses and epidermal barrier integrity.

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Ganoderma lucidum (Ganoderic Acid A)

PubChem CID: 112521

Ganoderma lucidum functions as a potent immunomodulator and adaptogen, primarily through the activation of toll-like receptors and the modulation of NF-κB signaling pathways to enhance cytokine production and cellular antioxidant defenses.

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Ganoderma lucidum (Ganoderic acid A)

PubChem CID: 11243918

Ganoderic acid A acts as a highly selective triterpenoid modulator of the NF-κB and AP-1 signaling pathways, exerting potent anti-inflammatory, hepatoprotective, and anti-tumorigenic effects through the inhibition of pro-inflammatory cytokine expression.

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Gardenia jasminoides (Geniposide)

PubChem CID: 107848

Geniposide is a bioactive iridoid glycoside that acts as a glucagon-like peptide-1 receptor (GLP-1R) agonist, providing significant hepatoprotective, anti-inflammatory, and neuroprotective effects through the modulation of the NF-κB and MAPK signaling pathways.

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Garlic Extract (Allicin)

PubChem CID: 65036

Garlic extract functions as a potent cardiovascular and antimicrobial agent by modulating H2S signaling pathways and inhibiting HMG-CoA reductase to improve lipid profiles and endothelial function.

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Gastrodia elata (Gastrodin)

PubChem CID: 115067

Gastrodia elata functions primarily as a neuroprotective agent by modulating GABAergic neurotransmission and inhibiting oxidative stress-induced neuronal apoptosis via the Nrf2/HO-1 signaling pathway.

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Genistein

PubChem CID: 5280961

Genistein is a phytoestrogenic isoflavone that modulates estrogen receptor beta (ERβ) signaling and inhibits tyrosine kinases to exert osteoprotective, cardioprotective, and chemopreventive effects.

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Gentiana lutea (Gentiopicroside)

PubChem CID: 88708

Gentiopicroside is a secoiridoid glycoside that exerts potent amaroidal effects to stimulate gastric secretions and hepatoprotective activity by modulating the Nrf2/HO-1 signaling pathway and suppressing pro-inflammatory cytokines.

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Gentiobiose

PubChem CID: 439543

Gentiobiose is a rare β(1→6)-linked disaccharide that functions as a key structural component in bioactive glycosides and serves as a selective prebiotic substrate for modulating the human gut microbiome.

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Gentiooligosaccharides (Gentiobiose)

PubChem CID: 441422

Gentiooligosaccharides function as non-digestible prebiotic fibers that selectively stimulate the growth of Bifidobacteria and Lactobacilli while modulating the gut-brain axis through short-chain fatty acid production.

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Germanium Sesquioxide (Ge-132)

PubChem CID: 98564

Germanium Sesquioxide functions as an organometallic immunomodulator that stimulates endogenous interferon production and enhances macrophage activity while providing significant antioxidant protection against lipid peroxidation.

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Ginger Root (6-Gingerol)

PubChem CID: 442435

Ginger root extract functions primarily through the modulation of eicosanoid synthesis via COX-2 inhibition and the antagonism of 5-HT3 receptors in the gastrointestinal tract to exert potent anti-inflammatory and anti-emetic effects.

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Ginger Root (6-Gingerol)

PubChem CID: 442431

6-Gingerol is a pungent phenolic compound that modulates TRPV1 and 5-HT3 receptors, exerting potent anti-emetic, anti-inflammatory, and thermogenic effects through the inhibition of pro-inflammatory cytokines and prostaglandin synthesis.

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Ginkgo Biloba (Ginkgolide B)

PubChem CID: 38124

Ginkgo biloba extract modulates cerebral hemodynamics and neuroprotection via antagonism of platelet-activating factor (PAF) receptors and scavenging of reactive oxygen species (ROS) to enhance cognitive function and microcirculatory flow.

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Ginkgo Biloba (Ginkgolide B)

PubChem CID: 6324617

Ginkgolide B is a potent, competitive antagonist of the platelet-activating factor (PAF) receptor, exerting significant neuroprotective and anti-inflammatory effects by modulating microvascular permeability and inhibiting PAF-induced platelet aggregation.

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Ginkgo biloba (Ginkgolide B)

PubChem CID: 6324617

Ginkgolide B acts as a potent, selective antagonist of the platelet-activating factor (PAF) receptor, modulating neuroinflammation and enhancing microcirculatory perfusion through the inhibition of PAF-induced platelet aggregation.

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Glucoamylase (Amyloglucosidase)

PubChem CID: 131676114

Glucoamylase is a specialized exo-hydrolase that catalyzes the hydrolysis of terminal 1,4-linked alpha-D-glucose residues successively from non-reducing ends of amylose and amylopectin chains, facilitating complete starch-to-glucose conversion for glycemic management and digestive support.

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Glucosamine Hydrochloride

PubChem CID: 9852447

Glucosamine Hydrochloride serves as a fundamental biochemical precursor for the synthesis of glycosaminoglycans and proteoglycans within the extracellular matrix of articular cartilage, facilitating structural repair and attenuating inflammatory pathways in degenerative joint conditions.

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Glucosamine Sulfate

PubChem CID: 115129

Glucosamine sulfate acts as a fundamental substrate for the biosynthetic rate-limiting step of glycosaminoglycan and proteoglycan production within the articular cartilage matrix, primarily utilized to mitigate joint space narrowing in osteoarthritic pathologies.

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Glucosamine Sulfate Potassium Chloride

PubChem CID: 16212450

Glucosamine sulfate potassium chloride serves as a stabilized exogenous precursor for glycosaminoglycan and proteoglycan synthesis within the articular cartilage matrix, primarily utilized to mitigate osteoarthritic degradation and support synovial fluid viscosity.

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Glutathione (L-Glutathione)

PubChem CID: 12488

Glutathione is a tripeptide thiol that serves as the primary endogenous antioxidant and nucleophilic co-substrate for glutathione S-transferase enzymes, critical for neutralizing reactive oxygen species and facilitating Phase II detoxification.

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Glycine

PubChem CID: 750

Glycine functions as a proteogenic amino acid and inhibitory neurotransmitter that modulates NMDA receptor activity and serves as a rate-limiting precursor for glutathione synthesis to support metabolic and neurological homeostasis.

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Glycyrrhiza glabra (Glycyrrhizic Acid)

PubChem CID: 14982

Glycyrrhiza glabra functions primarily as a mineralocorticoid-mimetic and anti-inflammatory agent by inhibiting 11β-hydroxysteroid dehydrogenase, thereby modulating cortisol metabolism and providing cytoprotective effects on gastric mucosa.

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Glycyrrhiza glabra (Glycyrrhizin)

PubChem CID: 14982

Glycyrrhizin acts as a potent inhibitor of 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2), effectively modulating cortisol metabolism and exerting significant anti-inflammatory and hepatoprotective effects through the HMGB1 signaling pathway.

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Glycyrrhiza uralensis (Glycyrrhizic acid)

PubChem CID: 14982

Glycyrrhizic acid functions as a potent triterpenoid saponin that modulates the 11β-hydroxysteroid dehydrogenase enzyme system to prolong cortisol half-life and exerts significant anti-inflammatory effects through the inhibition of HMGB1 signaling pathways.

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Glycyrrhiza uralensis (Glycyrrhizin)

PubChem CID: 14982

Glycyrrhizin acts as a potent anti-inflammatory and hepatoprotective triterpenoid saponin by inhibiting 11β-hydroxysteroid dehydrogenase and modulating the HMGB1-TLR4 signaling pathway.

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Gotu Kola (Asiaticoside)

PubChem CID: 73000

Gotu Kola functions as a dermatological and neurological modulator by stimulating collagen synthesis through TGF-β signaling and enhancing microcirculation via the modulation of connective tissue integrity.

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Grape Seed Extract (Procyanidin B1)

PubChem CID: 112501

Procyanidin B1 is a dimeric proanthocyanidin that functions as a potent antioxidant and anti-inflammatory agent, primarily utilized for cardiovascular protection and the modulation of oxidative stress pathways.

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Grape Seed Extract (Procyanidin B2)

PubChem CID: 122738

Grape seed extract functions as a potent antioxidant and vasoprotective agent by modulating nitric oxide signaling and inhibiting matrix metalloproteinases to enhance endothelial function and connective tissue integrity.

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Grapefruit Extract (Naringin)

PubChem CID: 442428

Naringin is a flavanone glycoside that modulates lipid metabolism and exhibits potent antioxidant properties by inhibiting cytochrome P450 enzymes and scavenging reactive oxygen species.

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Green Coffee Bean (Chlorogenic Acid)

PubChem CID: 1794427

A polyphenolic ester of caffeic acid and quinic acid that modulates glucose metabolism by inhibiting glucose-6-phosphatase and reducing intestinal glucose absorption via sodium-dependent glucose transporter inhibition.

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Green Tea Extract (Epigallocatechin Gallate)

PubChem CID: 65064

Green Tea Extract, primarily standardized for Epigallocatechin Gallate (EGCG), functions as a potent polyphenol that modulates AMPK signaling pathways and inhibits catechol-O-methyltransferase to enhance metabolic rate and provide systemic antioxidant protection.

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Green Tea Extract (Epigallocatechin Gallate)

PubChem CID: 65064

A potent catechin polyphenol that modulates cellular signaling pathways, including AMPK activation and COMT inhibition, to enhance metabolic rate and provide neuroprotective antioxidant effects.

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Grifola frondosa (Beta-1,6-glucan)

PubChem CID: 10887611

Maitake D-fraction acts as a potent biological response modifier by activating macrophages, natural killer cells, and cytotoxic T-cells through the dectin-1 receptor pathway to enhance innate and adaptive immune surveillance.

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Guggul (Guggulsterone)

PubChem CID: 5284619

Guggulsterones act as potent farnesoid X receptor (FXR) antagonists and pregnane X receptor (PXR) ligands, modulating cholesterol metabolism and exhibiting anti-inflammatory activity through NF-κB inhibition.

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Guggul Extract (Guggulsterones)

PubChem CID: 5284647

Guggulsterones function as potent antagonists of the farnesoid X receptor (FXR), modulating bile acid metabolism and cholesterol homeostasis while simultaneously inhibiting NF-κB-mediated inflammatory pathways.

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Gymnema Sylvestre (Gymnemic Acid)

PubChem CID: 101111

Gymnema sylvestre functions as a potent antihyperglycemic agent by competitively inhibiting glucose absorption at the intestinal SGLT1 receptors and stimulating pancreatic beta-cell regeneration to enhance endogenous insulin secretion.

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Gymnema sylvestre (Gymnemic Acid)

PubChem CID: 11953901

Gymnema sylvestre functions as a potent hypoglycemic agent by inhibiting intestinal glucose absorption via competitive binding at SGLT1 receptors and stimulating pancreatic beta-cell regeneration to enhance endogenous insulin secretion.

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Gymnema sylvestre (Gymnemic Acid)

PubChem CID: 11953901

Gymnema sylvestre acts as a potent hypoglycemic agent by competitively inhibiting glucose absorption in the small intestine and stimulating insulin secretion through the regeneration of pancreatic beta-cells.

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Haematococcus pluvialis (Astaxanthin)

PubChem CID: 5281224

A potent xanthophyll carotenoid that functions as a high-capacity singlet oxygen quencher and membrane-spanning antioxidant, primarily utilized for mitigating systemic oxidative stress and enhancing dermal and ocular photoprotection.

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Haematococcus pluvialis (Astaxanthin)

PubChem CID: 5281224

A potent xanthophyll carotenoid that exerts systemic antioxidant effects by spanning the phospholipid bilayer to neutralize reactive oxygen species and modulate the Nrf2/ARE signaling pathway.

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Hawthorn Berry Extract (Vitexin)

PubChem CID: 5280441

Hawthorn berry extract functions as a cardiotonic agent by enhancing myocardial contractility and coronary blood flow through the modulation of intracellular calcium and inhibition of angiotensin-converting enzyme (ACE).

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Hemicellulase

PubChem CID: 131869854

Hemicellulase is a multi-enzyme complex that catalyzes the hydrolysis of non-starch polysaccharides into fermentable sugars, thereby reducing intestinal viscosity and mitigating the symptoms of malabsorption and flatulence associated with high-fiber diets.

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Hericium erinaceus (Erinacine A)

PubChem CID: 10141644

Erinacine A functions as a potent low-molecular-weight stimulator of Nerve Growth Factor (NGF) synthesis through the activation of the JNK signaling pathway, facilitating neurogenesis and myelin sheath repair.

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Hesperidin

PubChem CID: 10621

Hesperidin is a flavanone glycoside primarily found in citrus fruits that exerts vasoprotective, anti-inflammatory, and antioxidant effects by modulating capillary permeability and inhibiting pro-inflammatory cytokine signaling.

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Holarrhena antidysenterica (Conessine)

PubChem CID: 92742

Kutaja functions primarily as an amoebicidal and antidiarrheal agent by inhibiting the growth of Entamoeba histolytica and modulating intestinal motility through steroidal alkaloid-mediated antagonism of muscarinic receptors.

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Holy Basil Extract (Ursolic Acid)

PubChem CID: 64945

Holy Basil functions as a potent adaptogen by modulating the hypothalamic-pituitary-adrenal (HPA) axis and inhibiting pro-inflammatory cytokines such as IL-6 and TNF-α via the downregulation of NF-κB signaling pathways.

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Homotaurine (3-Aminopropanesulfonic Acid)

PubChem CID: 10476

Homotaurine is a synthetic small-molecule analog of taurine that acts as a GABAergic agonist and an anti-amyloidogenic agent, primarily utilized for its neuroprotective potential in mitigating cognitive decline and amyloid-beta aggregation.

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Horny Goat Weed (Icariin)

PubChem CID: 5318997

Horny Goat Weed extract functions primarily as a natural phosphodiesterase type 5 (PDE5) inhibitor and a promoter of nitric oxide synthesis, facilitating improved erectile function and bone density through the modulation of cGMP signaling pathways.

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Hovenia dulcis (Dihydromyricetin)

PubChem CID: 161241

Dihydromyricetin functions as a potent flavonoid modulator of GABA-A receptors and an inducer of ethanol-metabolizing enzymes, primarily utilized for mitigating alcohol-induced hepatotoxicity and neuro-excitability.

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Humulus lupulus (Xanthohumol)

PubChem CID: 639665

Humulus lupulus functions as a potent sedative and anxiolytic agent primarily through the positive allosteric modulation of GABA-A receptors and the induction of the Nrf2-mediated antioxidant response via its prenylated flavonoid constituents.

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Hyaluronic Acid

PubChem CID: 24749

A high-molecular-weight glycosaminoglycan that functions as a critical component of the extracellular matrix, facilitating tissue hydration, viscoelasticity, and chondrocyte protection through CD44 receptor interaction.

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Hydrastis canadensis (Berberine)

PubChem CID: 2353

An isoquinoline alkaloid that modulates metabolic homeostasis via AMPK activation and exerts broad-spectrum antimicrobial effects by inhibiting bacterial efflux pumps and nucleic acid synthesis.

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Inonotus obliquus (Betulinic acid)

PubChem CID: 64971

Inonotus obliquus functions as a potent immunomodulator and antineoplastic agent by leveraging betulinic acid to induce mitochondrial-mediated apoptosis in malignant cells while suppressing NF-κB-driven inflammatory cascades.

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Inulin (Fructo-oligosaccharide)

PubChem CID: 24763

Inulin functions as a non-digestible fermentable prebiotic fiber that selectively stimulates the growth of Bifidobacteria and Lactobacilli, thereby modulating the gut-brain axis and improving mineral absorption through colonic acidification.

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Invertase (Beta-fructofuranosidase)

PubChem CID: 102212261

Invertase is a carbohydrate-digesting enzyme that catalyzes the hydrolysis of sucrose into glucose and fructose, facilitating glycemic management and reducing the osmotic load of undigested disaccharides in the gastrointestinal tract.

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Isatis tinctoria (Indirubin)

PubChem CID: 10177

Indirubin acts as a potent cyclin-dependent kinase (CDK) and glycogen synthase kinase-3 beta (GSK-3β) inhibitor, primarily utilized for its anti-proliferative and anti-inflammatory properties in dermatological and oncological research.

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Isomaltooligosaccharides (Isomaltose)

PubChem CID: 439183

Isomaltooligosaccharides function as prebiotic fibers that selectively stimulate the growth of beneficial bifidobacteria and lactobacilli in the gastrointestinal tract while providing a low-glycemic alternative to sucrose.

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Isomaltulose

PubChem CID: 439193

Isomaltulose is a functional disaccharide characterized by an alpha-1,6-glycosidic bond that ensures slow enzymatic hydrolysis and a low-glycemic energy supply for sustained metabolic and cognitive performance.

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Isorhamnetin

PubChem CID: 5281654

Isorhamnetin is a 3'-O-methylated flavonoid that exhibits potent antioxidant, anti-inflammatory, and cardiovascular protective effects by modulating the PI3K/Akt and NF-κB signaling pathways.

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Kaempferol

PubChem CID: 5280863

Kaempferol is a dietary flavonol that modulates oxidative stress and inflammatory signaling pathways, primarily through the inhibition of NF-κB and the activation of Nrf2, while exhibiting potent chemopreventive and cardioprotective properties.

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Konjac Root (Glucomannan)

PubChem CID: 44134223

A high-molecular-weight water-soluble polysaccharide that functions as a fermentable dietary fiber, exerting hypoglycemic and hypolipidemic effects through the modulation of gastric emptying and the inhibition of intestinal cholesterol absorption.

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Konjac Root (Glucomannan)

PubChem CID: 439258

A high-molecular-weight water-soluble polysaccharide that functions as a fermentable dietary fiber, exerting hypoglycemic and hypolipidemic effects through the formation of a viscous gel matrix in the gastrointestinal tract.

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L-Alanyl-L-Glutamine

PubChem CID: 95977

A stable dipeptide that enhances electrolyte and water absorption across the intestinal lumen while supporting muscle protein synthesis and immune function during physiological stress.

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L-Arginine

PubChem CID: 6322

L-Arginine serves as the primary substrate for nitric oxide synthase (NOS), facilitating endogenous nitric oxide production to modulate vasodilation, endothelial function, and urea cycle nitrogen clearance.

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L-Ascorbic Acid

PubChem CID: 5467006

L-Ascorbic Acid acts as a potent water-soluble antioxidant and essential cofactor for prolyl and lysyl hydroxylases, facilitating collagen biosynthesis and neutralizing reactive oxygen species within the extracellular matrix.

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L-Carnitine

PubChem CID: 10917

L-Carnitine functions as an essential cofactor for the transport of long-chain fatty acids into the mitochondrial matrix via the carnitine palmitoyltransferase system, facilitating beta-oxidation and ATP production while mitigating oxidative stress in metabolic and cardiovascular pathologies.

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L-Carnitine L-Tartrate

PubChem CID: 119538

L-Carnitine L-Tartrate is a stable salt form of L-carnitine that facilitates long-chain fatty acid transport into the mitochondrial matrix for beta-oxidation and modulates androgen receptor density to enhance recovery from high-intensity exercise.

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L-Citrulline

PubChem CID: 9750

L-Citrulline acts as a potent endogenous precursor to L-arginine, facilitating the urea cycle and enhancing nitric oxide-mediated vasodilation to improve hemodynamic performance and reduce muscular fatigue.

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L-Glutamine

PubChem CID: 5960

L-Glutamine serves as a critical nitrogen donor and primary metabolic fuel for rapidly dividing cells, including enterocytes and lymphocytes, facilitating intestinal mucosal integrity and systemic immune function.

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L-Histidine

PubChem CID: 6274

L-histidine is an essential amino acid and precursor to histamine that modulates systemic pH buffering via carnosine synthesis and supports immune response through mast cell regulation.

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L-Hydroxyproline

PubChem CID: 5810

A non-essential amino acid derived from post-translational proline hydroxylation that serves as a critical structural component of collagen, facilitating triple-helix stability through interchain hydrogen bonding and acting as a primary biomarker for connective tissue turnover.

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L-Isoleucine

PubChem CID: 6306

L-isoleucine is a branched-chain amino acid that functions as a critical proteogenic precursor and metabolic regulator, primarily facilitating glucose uptake via GLUT4 translocation and promoting muscle protein synthesis through the mTOR signaling pathway.

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L-Leucine

PubChem CID: 6106

L-leucine is a proteogenic branched-chain amino acid that acts as a potent nutritional signal to stimulate muscle protein synthesis via the activation of the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway.

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L-Lysine

PubChem CID: 5962

L-Lysine is an essential proteinogenic amino acid that functions as a precursor to carnitine and collagen while exhibiting antagonistic effects on arginine-dependent viral replication, particularly in Herpes Simplex Virus (HSV) management.

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L-Lysine Hydrochloride

PubChem CID: 6288

L-lysine hydrochloride is an essential amino acid that functions as a competitive antagonist to L-arginine to inhibit viral replication and serves as a critical precursor for hydroxylysine in the cross-linking of collagen polypeptides.

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L-Methionine

PubChem CID: 6137

An essential sulfur-containing proteinogenic amino acid that serves as the primary precursor for S-adenosylmethionine (SAMe) and glutathione, facilitating critical transmethylation and transsulfuration pathways for hepatic detoxification and cellular proteostasis.

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L-Ornithine

PubChem CID: 6262

L-Ornithine is a non-proteinogenic amino acid that functions as a key intermediate in the urea cycle, facilitating the detoxification of ammonia and potentially enhancing growth hormone secretion and physical recovery.

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L-Phenylalanine

PubChem CID: 6140

L-phenylalanine is an essential aromatic amino acid that serves as a metabolic precursor to the catecholamine neurotransmitters dopamine, norepinephrine, and epinephrine, primarily utilized for cognitive enhancement and mood regulation.

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L-Proline

PubChem CID: 145742

L-Proline is a proteinogenic cyclic amino acid that serves as a critical precursor for hydroxyproline in collagen synthesis, facilitating structural integrity of connective tissues and wound healing through TGF-beta signaling pathways.

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L-Selenomethionine

PubChem CID: 15103

L-Selenomethionine is a highly bioavailable organic form of selenium that serves as a critical precursor for glutathione peroxidase synthesis, providing potent antioxidant protection and supporting thyroid hormone metabolism via deiodinase enzyme regulation.

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L-Theanine

PubChem CID: 439378

L-Theanine is a non-proteinogenic amino acid that modulates alpha-wave brain activity and antagonizes glutamate receptors to facilitate anxiolysis and cognitive focus without inducing somnolence.

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L-Threonine

PubChem CID: 6288

L-threonine is an essential ketogenic and glucogenic amino acid that serves as a primary structural component of mucin proteins and a metabolic precursor to glycine, facilitating intestinal mucosal integrity and spinal cord inhibitory neurotransmission.

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L-Tryptophan

PubChem CID: 6305

L-tryptophan serves as the essential proteogenic precursor for the biosynthesis of serotonin and melatonin via the tryptophan hydroxylase pathway, primarily utilized to modulate circadian rhythms and affective neurological states.

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L-Tyrosine

PubChem CID: 6057

L-Tyrosine serves as a rate-limiting proteogenic precursor for catecholamine neurotransmitters, specifically dopamine, norepinephrine, and epinephrine, primarily utilized to mitigate cognitive decline during acute environmental or psychological stress.

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L-Valine

PubChem CID: 6287

L-Valine is a branched-chain essential amino acid (BCAA) that acts as a glucogenic precursor and proteogenic substrate, primarily utilized for muscle tissue repair, nitrogen balance maintenance, and glucose metabolism regulation during physical exertion.

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Lactase (Beta-Galactosidase)

PubChem CID: 131751147

Lactase is a glycoside hydrolase enzyme that catalyzes the hydrolysis of lactose into glucose and galactose, primarily used to mitigate symptoms of lactose intolerance by compensating for endogenous enzyme deficiency in the small intestine.

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Lactitol

PubChem CID: 15730

Lactitol is a synthetic disaccharide polyol that functions as an osmotic laxative and prebiotic by resisting upper gastrointestinal digestion and undergoing fermentation by colonic microbiota into short-chain fatty acids, thereby lowering luminal pH and facilitating ammonia excretion in hepatic encephalopathy.

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Lacto-N-neotetraose

PubChem CID: 439223

Lacto-N-neotetraose is a neutral human milk oligosaccharide that functions as a selective prebiotic substrate for Bifidobacteria and a decoy receptor for enteric pathogens to modulate mucosal immunity.

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Lacto-N-tetraose

PubChem CID: 123831

A core human milk oligosaccharide (HMO) that acts as a selective prebiotic substrate for Bifidobacterium species, modulating gut microbiota composition and supporting neonatal immune system maturation.

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Lactobionic Acid

PubChem CID: 86556

Lactobionic acid is a polyhydroxy bionic acid that functions as a potent humectant, antioxidant, and metal chelator, primarily utilized in dermatological and organ preservation formulations to mitigate oxidative stress and enhance barrier function.

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Lactosucrose

PubChem CID: 115144

Lactosucrose is a non-digestible trisaccharide that functions as a selective prebiotic to stimulate the proliferation of Bifidobacteria and enhance intestinal mineral absorption through the acidification of the colonic lumen.

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Lactulose

PubChem CID: 11333

A synthetic disaccharide acting as an osmotic laxative and prebiotic that acidifies the colonic environment to facilitate the conversion of ammonia to non-absorbable ammonium ions, primarily used in treating chronic constipation and hepatic encephalopathy.

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Laminarin

PubChem CID: 439223

A β(1→3)-glucan with β(1→6)-linkages derived from brown algae, primarily investigated for its immunomodulatory effects via Dectin-1 receptor activation and its potential as a prebiotic for gut microbiota modulation.

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Larch Arabinogalactan (Arabinogalactan)

PubChem CID: 441347

Larch Arabinogalactan is a highly branched, long-chain polysaccharide that functions as a prebiotic and immunomodulator by stimulating natural killer cell activity and modulating cytokine production through gut-associated lymphoid tissue (GALT) interactions.

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Larch Arabinogalactan (Arabinogalactan)

PubChem CID: 441348

Arabinogalactan is a highly branched, long-chain polysaccharide that functions as a potent prebiotic and immunomodulator by enhancing natural killer cell activity and modulating cytokine production via the gut-associated lymphoid tissue.

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Lauric Acid

PubChem CID: 3893

A medium-chain saturated fatty acid that exerts potent antimicrobial effects by disrupting pathogen lipid membranes and serves as a precursor to monolaurin for systemic immune modulation.

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Lavandula angustifolia (Linalool)

PubChem CID: 6549

Lavandula angustifolia exerts potent anxiolytic and sedative effects primarily through the modulation of GABA-A receptors and inhibition of voltage-gated calcium channels by its primary monoterpene constituents.

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Lemon Balm (Rosmarinic Acid)

PubChem CID: 5281792

Lemon balm extract functions primarily as a potent inhibitor of GABA-transaminase (GABA-T), effectively increasing endogenous GABA concentrations to modulate the hypothalamic-pituitary-adrenal axis for anxiolytic and cognitive enhancement applications.

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Lentinula edodes (Lentinan)

PubChem CID: 37736

Lentinan is a high-molecular-weight β-(1→3)-glucan with β-(1→6)-branches that exerts potent immunomodulatory effects by activating cytotoxic T-lymphocytes and natural killer cells through the Dectin-1 receptor pathway.

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Leonurus cardiaca (Leonurine)

PubChem CID: 155583

Leonurus cardiaca functions as a cardiovascular and uterine tonic by modulating calcium channels and antagonizing alpha-adrenergic receptors to exert hypotensive, anti-arrhythmic, and emmenagogue effects.

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Ligusticum chuanxiong (Ferulic acid)

PubChem CID: 445858

Ligusticum chuanxiong exerts potent neuroprotective and vasodilatory effects primarily through ferulic acid-mediated inhibition of oxidative stress and modulation of the nitric oxide pathway to improve cerebrovascular circulation.

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Ligusticum chuanxiong (Ligustrazine)

PubChem CID: 14296

Ligustrazine functions as a potent calcium channel antagonist and phosphodiesterase inhibitor, primarily utilized for its vasodilatory, anti-platelet, and neuroprotective properties in cardiovascular and cerebrovascular pathologies.

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Lion's Mane (Hericenone C)

PubChem CID: 10430371

Hericenone C is a meroterpenoid derived from Hericium erinaceus that promotes neurogenesis by stimulating the synthesis and secretion of Nerve Growth Factor (NGF) in astrocytes via the activation of the JNK signaling pathway.

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Lion's Mane Mushroom (Erinacine A)

PubChem CID: 10452352

Hericium erinaceus extract functions as a potent neurotrophic agent by stimulating the endogenous synthesis of Nerve Growth Factor (NGF) through the activation of the ERK1/2 signaling pathway, thereby facilitating neurite outgrowth and cognitive recovery.

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Lipase (Triacylglycerol Lipase)

PubChem CID: 159355

Lipase is a biocatalytic enzyme that facilitates the hydrolytic cleavage of long-chain triacylglycerols into free fatty acids and glycerol, primarily utilized in clinical formulations to manage exocrine pancreatic insufficiency and optimize lipid-soluble nutrient absorption.

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Lithium Orotate

PubChem CID: 16213830

Lithium orotate acts as a neuroprotective agent by modulating glycogen synthase kinase-3 beta (GSK-3β) activity and enhancing brain-derived neurotrophic factor (BDNF) expression to stabilize mood and support cognitive longevity.

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Lutein

PubChem CID: 5281243

Lutein is a xanthophyll carotenoid that selectively accumulates in the macular pigment of the retina, where it exerts potent antioxidant effects and filters high-energy blue light to mitigate photo-oxidative damage and support visual acuity.

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Luteolin

PubChem CID: 5280445

Luteolin is a flavone that modulates neuroinflammation and cellular senescence by inhibiting the NF-κB and MAPK signaling pathways while activating Nrf2-mediated antioxidant defenses.

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Lycium barbarum (Zeaxanthin dipalmitate)

PubChem CID: 5281250

Zeaxanthin dipalmitate acts as a highly lipophilic macular carotenoid ester that selectively accumulates in the fovea centralis to attenuate photo-oxidative damage and enhance visual acuity via blue-light filtration.

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Lycium barbarum (Zeaxanthin)

PubChem CID: 5280899

Lycium barbarum serves as a concentrated source of zeaxanthin dipalmitate, a xanthophyll carotenoid that selectively accumulates in the macular pigment to provide photoprotective antioxidant activity against high-energy blue light and oxidative stress.

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Lycopene

PubChem CID: 446925

Lycopene is a lipophilic tetraterpene carotenoid that functions as a potent antioxidant and singlet oxygen quencher, primarily utilized for its cardioprotective and prostate-specific chemopreventive properties.

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Lysozyme (Muramidase)

PubChem CID: 5950

Lysozyme is a glycoside hydrolase that selectively catalyzes the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in bacterial peptidoglycan, serving as a critical antimicrobial agent in innate immunity.

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Maca Root (Macamide)

PubChem CID: 10430171

Maca root extract modulates the hypothalamic-pituitary-gonadal axis and endocannabinoid system via macamide-mediated inhibition of fatty acid amide hydrolase (FAAH) to enhance libido and adaptogenic resilience.

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Magnesium Glycinate

PubChem CID: 84645

Magnesium glycinate serves as a highly bioavailable chelated mineral complex that modulates NMDA receptor activity and supports GABAergic neurotransmission to facilitate systemic relaxation and metabolic homeostasis.

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Magnesium Malate

PubChem CID: 16212954

Magnesium malate serves as a highly bioavailable chelate that facilitates ATP production via the Krebs cycle while providing elemental magnesium for neuromuscular regulation and mitochondrial support.

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Magnesium Taurate

PubChem CID: 13181144

Magnesium Taurate functions as a highly bioavailable chelate that synergistically modulates NMDA receptor activity and cardiovascular tone through the combined inhibitory actions of magnesium ions and the sulfonic acid amino acid taurine.

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Magnolia Bark (Honokiol)

PubChem CID: 72303

Acts as a potent GABAergic modulator and PPAR-gamma agonist, primarily utilized for its anxiolytic, neuroprotective, and anti-inflammatory properties.

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Magnolia officinalis (Magnolol)

PubChem CID: 72394

Magnolol acts as a potent allosteric modulator of GABA-A receptors and a dual PPAR agonist, providing significant anxiolytic, neuroprotective, and anti-inflammatory effects through the inhibition of NF-κB and MAPK signaling pathways.

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Maltase (Alpha-glucosidase)

PubChem CID: 11966181

Maltase is a critical alpha-glucosidase enzyme localized in the brush border of the small intestine that catalyzes the hydrolysis of maltose into D-glucose to facilitate carbohydrate metabolism and energy homeostasis.

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Maltotriose

PubChem CID: 439340

A trisaccharide consisting of three glucose units linked with α-1,4 glycosidic bonds, primarily utilized as a rapid glycemic energy source and a substrate for amylolytic enzyme assays.

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Manganese Ascorbate

PubChem CID: 11954168

Manganese ascorbate functions as a dual-action nutritional agent, providing bioavailable manganese as a critical cofactor for glycosyltransferase enzymes in proteoglycan synthesis while utilizing the ascorbate moiety to stabilize redox potential and support collagen hydroxylation.

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Manganese Citrate

PubChem CID: 11954225

Manganese citrate serves as a highly bioavailable source of divalent manganese, acting as an essential cofactor for mitochondrial superoxide dismutase and enzymes involved in proteoglycan synthesis for bone and cartilage maintenance.

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Manganese Gluconate

PubChem CID: 11664

Acts as a bioavailable source of divalent manganese, serving as an essential cofactor for enzymes such as superoxide dismutase (MnSOD) and glycosyltransferases involved in bone mineralization and antioxidant defense.

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Manganese Sulfate

PubChem CID: 24408

Acts as a critical cofactor for enzymes like superoxide dismutase (MnSOD) and glycosyltransferases, facilitating antioxidant defense, bone mineralization, and carbohydrate metabolism.

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Mannan-oligosaccharides (Mannan)

PubChem CID: 439336

Mannan-oligosaccharides function as prebiotic ligands that competitively inhibit the adhesion of Type-1 fimbriated pathogens to the intestinal epithelium while modulating gut-associated lymphoid tissue (GALT) for enhanced mucosal immunity.

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Marigold Extract (Lutein)

PubChem CID: 5281243

Lutein is a xanthophyll carotenoid that selectively accumulates in the macular pigment of the retina, where it acts as a potent antioxidant and blue-light filter to mitigate oxidative stress and photo-induced damage.

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Marigold Extract (Zeaxanthin)

PubChem CID: 5280899

Zeaxanthin isomers function as potent xanthophyll carotenoids that selectively accumulate in the macula lutea to provide high-energy blue light filtration and neutralize photo-oxidative stress via singlet oxygen quenching.

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Marshmallow Root (L-Asparagine)

PubChem CID: 236

Marshmallow root extract functions primarily as a demulcent agent, utilizing high-molecular-weight polysaccharides to form a protective physical film over inflamed mucosal membranes to alleviate respiratory and gastrointestinal irritation.

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Matricaria chamomilla (Apigenin)

PubChem CID: 5280443

Matricaria chamomilla exerts anxiolytic and sedative effects primarily through the modulation of GABA-A receptors and inhibition of pro-inflammatory cytokines such as IL-6 and TNF-α via its flavonoid and terpenoid constituents.

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Melatonin

PubChem CID: 896

Melatonin is an indoleamine neurohormone that regulates circadian rhythmicity and sleep-wake cycles via MT1 and MT2 receptor agonism while providing potent antioxidant protection through direct free radical scavenging and upregulation of antioxidant enzymes.

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Melissa officinalis (Rosmarinic Acid)

PubChem CID: 5281792

Melissa officinalis functions as a potent inhibitor of GABA-transaminase and a modulator of muscarinic and nicotinic acetylcholine receptors, providing targeted anxiolytic and cognitive-enhancing effects through the preservation of neurotransmitter concentrations.

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Menaquinone-7

PubChem CID: 5281036

Menaquinone-7 acts as a critical cofactor for the gamma-glutamyl carboxylase enzyme, facilitating the post-translational modification of vitamin K-dependent proteins such as osteocalcin and matrix Gla protein to regulate systemic calcium sequestration and arterial decalcification.

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Meso-zeaxanthin

PubChem CID: 5281243

A xanthophyll carotenoid that selectively accumulates in the macula lutea, providing photoprotection against high-energy blue light and neutralizing reactive oxygen species to maintain retinal integrity.

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Methylcobalamin

PubChem CID: 16212801

Methylcobalamin functions as a critical cofactor for methionine synthase, facilitating the remethylation of homocysteine to methionine and supporting neuronal integrity through the maintenance of the myelin sheath.

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Methylsulfonylmethane

PubChem CID: 6213

Methylsulfonylmethane serves as an organosulfur donor that modulates systemic inflammatory cascades by inhibiting NF-κB activation and reducing the expression of pro-inflammatory cytokines such as IL-6 and TNF-α.

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Milk Thistle (Silybin)

PubChem CID: 31553

Silybin is a hepatoprotective flavonolignan that modulates nuclear factor-kappa B (NF-κB) signaling and enhances protein synthesis in hepatocytes by stimulating RNA polymerase I activity.

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Milk Thistle Extract (Silybin)

PubChem CID: 31553

Milk Thistle extract acts primarily as a hepatoprotective agent by modulating nuclear factor-kappa B (NF-κB) signaling and enhancing protein synthesis in hepatocytes through the stimulation of RNA polymerase I.

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Momordica charantia (Charantin)

PubChem CID: 10131250

Momordica charantia exerts potent hypoglycemic effects through the activation of AMP-activated protein kinase (AMPK) and the insulin-independent translocation of GLUT4 to the plasma membrane, facilitating peripheral glucose uptake and inhibiting hepatic gluconeogenesis.

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Moringa oleifera (Moringin)

PubChem CID: 11119530

Moringa oleifera functions as a potent cytoprotective agent by modulating the Nrf2/ARE signaling pathway and inhibiting pro-inflammatory cytokines like TNF-α and IL-6, primarily through its high concentration of glycosylated isothiocyanates.

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Mucuna pruriens (L-Dopa)

PubChem CID: 6047

Mucuna pruriens serves as a natural precursor to dopamine via its high concentration of L-Dopa, crossing the blood-brain barrier to modulate catecholamine synthesis and support neuroendocrine function in Parkinsonian and hyperprolactinemic contexts.

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Mucuna pruriens (L-Dopa)

PubChem CID: 6047

A dopaminergic precursor that crosses the blood-brain barrier to increase dopamine synthesis, primarily utilized for neuroprotection, motor function support, and endocrine regulation of prolactin.

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Myo-inositol

PubChem CID: 892

Myo-inositol acts as a carbocyclic polyol that serves as a structural precursor for the phosphoinositide signaling pathway, modulating insulin sensitivity and gonadotropin signaling through the second messenger inositol phosphoglycan (IPG) system.

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Myricetin

PubChem CID: 5281672

Myricetin is a polyhydroxyl flavonol that modulates glucose metabolism and provides neuroprotection through the inhibition of oxidative stress and the regulation of SIRT1 and PI3K/Akt signaling pathways.

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Myristic Acid

PubChem CID: 11005

A long-chain saturated fatty acid that functions as a critical substrate for N-myristoyltransferase, facilitating the lipidation and membrane anchoring of signaling proteins involved in cellular transduction and immune response.

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N-Acetyl Cysteine

PubChem CID: 12035

N-Acetyl Cysteine acts as a thiol-based antioxidant and rate-limiting precursor for glutathione synthesis, facilitating the detoxification of reactive oxygen species and the reduction of disulfide bonds in mucoproteins.

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N-Acetyl-Carnosine

PubChem CID: 119058

N-Acetyl-Carnosine is a dipeptide derivative that functions as a prodrug to L-carnosine, specifically engineered for enhanced resistance to carnosinase degradation to provide sustained antioxidant protection against oxidative stress-induced protein glycation and lipid peroxidation in ocular and systemic tissues.

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N-Acetyl-D-Glucosamine

PubChem CID: 9072

N-Acetyl-D-Glucosamine serves as a key biochemical precursor for glycosaminoglycan synthesis and modulates intestinal barrier function by enhancing the production of the protective mucosal layer.

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N-Acetyl-L-Cysteine

PubChem CID: 12035

N-Acetyl-L-Cysteine acts as a rate-limiting precursor to glutathione synthesis, providing potent antioxidant support and mucolytic activity by reducing disulfide bonds in mucoproteins.

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Nardostachys jatamansi (Jatamansone)

PubChem CID: 10141

Nardostachys jatamansi functions as a potent neuroprotective and anxiolytic agent by modulating GABAergic signaling pathways and reducing oxidative stress within the hippocampal region.

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Nattokinase (Subtilisin NAT)

PubChem CID: 102198147

Nattokinase is a potent fibrinolytic serine protease derived from Bacillus subtilis var. natto that directly degrades fibrin and plasminogen activator inhibitor-1 to enhance cardiovascular hemodynamics and reduce thrombotic risk.

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Neem (Azadirachtin)

PubChem CID: 5281307

Azadirachta indica exerts potent immunomodulatory, antimicrobial, and anti-inflammatory effects primarily through the modulation of pro-inflammatory cytokines and oxidative stress pathways, making it a key candidate for dermatological and metabolic health applications.

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Neoxanthin

PubChem CID: 5281245

Neoxanthin is a xanthophyll carotenoid that functions as a potent antioxidant and photo-protective agent, primarily investigated for its ability to induce apoptosis in cancer cells and mitigate oxidative stress in ocular tissues.

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Nepeta cataria (Nepetalactone)

PubChem CID: 161500

Nepeta cataria functions primarily as a mild sedative and anxiolytic through the modulation of GABAergic signaling pathways, specifically via the interaction of its volatile iridoid nepetalactones with GABA-A receptors.

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Nervonic Acid

PubChem CID: 5281120

Nervonic acid is a long-chain monounsaturated fatty acid that serves as a critical structural component of sphingomyelin in the myelin sheath, facilitating axonal insulation and neuroregeneration in demyelinating disorders.

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Niacinamide

PubChem CID: 936

Niacinamide functions as a critical precursor for the synthesis of nicotinamide adenine dinucleotide (NAD+) and its phosphate (NADP+), facilitating essential hydride transfer in mitochondrial respiration and modulating poly(ADP-ribose) polymerase activity for DNA damage repair.

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Nickel Sulfate

PubChem CID: 24586

Nickel sulfate is a trace mineral compound primarily utilized in biochemical research as a cofactor for specific microbial enzymes like urease, though its human application is strictly limited by its narrow therapeutic window and high allergenic potential.

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Nicotinamide

PubChem CID: 936

Nicotinamide serves as a critical precursor to nicotinamide adenine dinucleotide (NAD+), facilitating redox reactions and DNA repair mechanisms via PARP activation while modulating sirtuin-mediated metabolic pathways.

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Nicotinamide Mononucleotide (NMN)

PubChem CID: 14159

Nicotinamide mononucleotide serves as a direct precursor to nicotinamide adenine dinucleotide (NAD+), functioning as a critical metabolic intermediate to enhance mitochondrial oxidative phosphorylation and activate sirtuin-mediated DNA repair pathways.

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Nicotinamide Riboside Chloride

PubChem CID: 44134747

Nicotinamide riboside chloride functions as a direct precursor to nicotinamide adenine dinucleotide (NAD+), enhancing mitochondrial bioenergetics and activating sirtuin-mediated DNA repair pathways to address age-related physiological decline.

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Oat Beta-Glucan (Beta-D-Glucan)

PubChem CID: 439261

Oat beta-glucan is a soluble fiber polysaccharide that modulates glycemic response and reduces LDL cholesterol by increasing intestinal viscosity and inhibiting bile acid reabsorption.

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Ocimum sanctum (Ursolic Acid)

PubChem CID: 64945

Ocimum sanctum functions as a potent adaptogen by modulating the hypothalamic-pituitary-adrenal (HPA) axis and exerting multi-pathway anti-inflammatory effects through the inhibition of COX-2 and LOX enzymes.

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Ocimum sanctum (Ursolic Acid)

PubChem CID: 64945

Ocimum sanctum functions as a potent adaptogen by modulating the hypothalamic-pituitary-adrenal (HPA) axis and exerting significant anti-inflammatory effects through the inhibition of COX-2 and LOX enzymes.

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Octacosanol

PubChem CID: 68406

Octacosanol is a long-chain primary fatty alcohol that modulates lipid metabolism and enhances physical performance by improving oxygen utilization and glycogen storage in muscle tissue.

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Olea europaea (Oleuropein)

PubChem CID: 5281544

Oleuropein is a secoiridoid glycoside that exerts potent cardioprotective, hypotensive, and anti-inflammatory effects by modulating oxidative stress and enhancing endothelial nitric oxide synthase activity.

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Oleic Acid

PubChem CID: 445639

A monounsaturated omega-9 fatty acid that modulates membrane fluidity and activates G protein-coupled receptor 120 (GPR120) to exert anti-inflammatory and insulin-sensitizing effects.

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Olive Leaf Extract (Oleuropein)

PubChem CID: 5281544

Olive leaf extract standardized to 20% oleuropein functions as a potent secoiridoid glycoside that modulates cardiovascular health through ACE inhibition, L-type calcium channel blockade, and significant reduction of oxidative stress markers.

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Olive Leaf Extract (Oleuropein)

PubChem CID: 5281544

Oleuropein is a secoiridoid glycoside that exerts potent cardioprotective and anti-inflammatory effects through the modulation of NF-κB signaling and the activation of the AMPK pathway.

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Ophiopogon japonicus (Ophiopogonin D)

PubChem CID: 11210854

Ophiopogonin D is a steroidal saponin that exerts potent cardioprotective and anti-inflammatory effects by modulating the TGF-β1/Smad signaling pathway and inhibiting CYP2J2-mediated arachidonic acid metabolism.

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Orthosilicic Acid

PubChem CID: 14942

Orthosilicic acid serves as the primary bioavailable source of silicon, acting as a critical structural cofactor for prolyl hydroxylase to stimulate Type I collagen synthesis and enhance bone mineral density through osteoblast modulation.

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Paeonia lactiflora (Paeoniflorin)

PubChem CID: 442534

Paeoniflorin is a monoterpene glycoside that exerts immunomodulatory and neuroprotective effects by inhibiting the TLR4/NF-κB signaling pathway and modulating the hypothalamic-pituitary-adrenal axis.

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Paeonia lactiflora (Paeoniflorin)

PubChem CID: 442534

Paeonia lactiflora functions primarily as an immunomodulatory and anti-inflammatory agent by inhibiting the production of pro-inflammatory cytokines and modulating the NF-κB signaling pathway.

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Palmitoleic Acid

PubChem CID: 445638

Palmitoleic acid (C16:1n-7) is an omega-7 monounsaturated fatty acid that functions as a lipokine, modulating systemic metabolic homeostasis by enhancing insulin sensitivity in skeletal muscle and suppressing hepatic lipogenesis.

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Palmitoylethanolamide

PubChem CID: 4671

Palmitoylethanolamide is an endogenous fatty acid amide that functions as a selective PPAR-α agonist and modulates mast cell activation to provide neuroprotective, anti-inflammatory, and analgesic effects through the entourage effect on the endocannabinoid system.

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Panax Ginseng (Ginsenoside Rb1)

PubChem CID: 9898273

Panax ginseng functions as a potent adaptogen by modulating the hypothalamic-pituitary-adrenal axis and enhancing cognitive performance through the neuroprotective and anti-inflammatory actions of its triterpenoid saponins.

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Panax ginseng (Ginsenoside Rb1)

PubChem CID: 9898273

Ginsenoside Rb1 acts as a protopanaxadiol-type saponin that modulates the hypothalamic-pituitary-adrenal axis and enhances neuroplasticity through the upregulation of brain-derived neurotrophic factor and modulation of GABAergic neurotransmission.

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Pantothenic Acid

PubChem CID: 6613

As the fundamental precursor to Coenzyme A, pantothenic acid is critical for the acetylation of proteins and the oxidative metabolism of carbohydrates, lipids, and amino acids within the mitochondrial matrix.

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Papaya Extract (Papain)

PubChem CID: 16130108

Papain is a cysteine protease derived from Carica papaya that catalyzes the hydrolysis of peptide bonds, functioning as a potent fibrinolytic and anti-inflammatory agent in systemic and digestive applications.

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Partially Hydrolyzed Guar Gum (Galactomannan)

PubChem CID: 16213645

Partially Hydrolyzed Guar Gum is a low-viscosity, soluble prebiotic galactomannan that modulates colonic microflora to increase short-chain fatty acid production and normalize intestinal transit time without the rapid fermentation kinetics associated with high-molecular-weight fibers.

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Passiflora incarnata (Apigenin)

PubChem CID: 5280443

Passiflora incarnata functions as a positive allosteric modulator of the GABA-A receptor complex and a mild monoamine oxidase inhibitor, primarily utilized for its anxiolytic and sedative properties in managing generalized anxiety disorder and sleep latency.

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Passionflower Extract (Vitexin)

PubChem CID: 5280441

Passionflower extract functions as a positive allosteric modulator of GABA-A receptors and a mild monoamine oxidase inhibitor, primarily utilized for its potent anxiolytic and sedative properties in managing sleep-wake cycle disturbances.

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Pectin (Galacturonic Acid)

PubChem CID: 441476

Pectin is a complex structural heteropolysaccharide that functions as a soluble prebiotic fiber and gelling agent, modulating postprandial glycemic response and lipid metabolism through the formation of high-viscosity intestinal matrices.

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Pectinase (Polygalacturonase)

PubChem CID: 131751341

Pectinase is a glycosyl hydrolase that catalyzes the hydrolytic cleavage of alpha-1,4-glycosidic bonds in pectic polysaccharides, primarily utilized in digestive health formulations to improve nutrient bioavailability and mitigate intestinal fermentation of complex plant fibers.

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Pelargonium sidoides (Umckalin)

PubChem CID: 119532

Pelargonium sidoides functions as a potent immunomodulator and antiviral agent by stimulating macrophage activity and inhibiting viral attachment to respiratory epithelial cells, primarily indicated for acute bronchitis and upper respiratory tract infections.

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Pepsin

PubChem CID: 131751341

Pepsin is a gastric aspartic protease that catalyzes the hydrolysis of peptide bonds in proteins into smaller peptides and amino acids, primarily functioning in the acidic environment of the stomach to initiate protein digestion.

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Peptidase (Serratiopeptidase)

PubChem CID: 131811140

Peptidases are proteolytic enzymes that catalyze the hydrolysis of peptide bonds, facilitating the degradation of inflammatory kinins and fibrin to modulate systemic inflammation and improve protein bioavailability.

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Peumus boldus (Boldine)

PubChem CID: 10154

Peumus boldus acts primarily as a hepatoprotective and choleretic agent through the aporphine alkaloid boldine, which exerts potent antioxidant effects by scavenging reactive oxygen species and modulating bile acid secretion via the stimulation of hepatocyte canalicular transport.

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Phosphatidylcholine

PubChem CID: 453

Phosphatidylcholine serves as a critical phospholipid precursor for acetylcholine synthesis and a structural component of cellular membranes, facilitating hepatic lipid metabolism and neurocognitive integrity through its role in the Kennedy pathway.

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Phosphatidylethanolamine

PubChem CID: 123831

Phosphatidylethanolamine is a critical glycerophospholipid that modulates membrane curvature and fluidity while serving as a metabolic precursor for phosphatidylcholine and a key regulator of mitochondrial fusion and autophagy.

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Phosphatidylinositol

PubChem CID: 445580

Phosphatidylinositol serves as a critical phospholipid precursor for the phosphoinositide signaling pathway, facilitating intracellular calcium mobilization and protein kinase C activation via its conversion to PIP2 and subsequent cleavage into IP3 and DAG.

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Phosphatidylserine

PubChem CID: 11001

Phosphatidylserine is a critical glycerophospholipid component of neuronal cell membranes that modulates signal transduction, neurotransmitter release, and cognitive function by maintaining membrane fluidity and supporting the activity of protein kinase C and Na+/K+-ATPase.

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Phosphatidylserine (Sunflower-derived)

PubChem CID: 445125

Phosphatidylserine is a critical membrane phospholipid that modulates neuronal signal transduction and maintains membrane fluidity to support cognitive function and cortisol regulation.

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Phyllanthus emblica (Emblicanin A)

PubChem CID: 119046

Emblicanin A is a low-molecular-weight hydrolyzable tannin that functions as a potent antioxidant by sequestering transition metal ions and neutralizing reactive oxygen species through a cascade-like redox mechanism, primarily utilized for cardioprotection and skin health.

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Phyllanthus emblica (Gallic Acid)

PubChem CID: 370

Phyllanthus emblica functions as a potent antioxidant and cytoprotective agent by utilizing a complex cascade of hydrolyzable tannins to neutralize reactive oxygen species and modulate the Nrf2/ARE signaling pathway for systemic oxidative stress reduction.

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Phyllanthus niruri (Corilagin)

PubChem CID: 73568

Phyllanthus niruri, standardized to the hydrolyzable tannin Corilagin, exerts potent anti-urolithic and hepatoprotective effects by inhibiting calcium oxalate crystallization and modulating the NF-κB and MAPK signaling pathways to reduce oxidative stress.

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Phyllanthus niruri (Phyllanthin)

PubChem CID: 114886

Phyllanthin serves as a potent lignan-based hepatoprotective and litholytic agent by modulating oxidative stress pathways and inhibiting the nucleation and aggregation of calcium oxalate crystals within the renal tubules.

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Phylloquinone (Vitamin K1)

PubChem CID: 5280483

Phylloquinone acts as an essential cofactor for the gamma-glutamyl carboxylase enzyme, facilitating the post-translational modification of vitamin K-dependent proteins critical for blood coagulation cascades and bone mineralization.

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Phytase (Myo-inositol-hexakisphosphate phosphohydrolase)

PubChem CID: 16218644

Phytase is a phosphohydrolase enzyme that catalyzes the stepwise dephosphorylation of phytic acid into lower inositol phosphates and inorganic phosphate, thereby increasing the bioavailability of chelated divalent cations such as calcium, magnesium, and zinc.

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Phytosphingosine

PubChem CID: 122121

A long-chain sphingoid base that serves as a critical precursor to ceramides, exhibiting potent antimicrobial, anti-inflammatory, and skin-barrier restorative properties through the modulation of lipid signaling pathways.

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Picrorhiza kurroa (Kutkin)

PubChem CID: 119033

Picrorhiza kurroa functions as a potent hepatoprotective and immunomodulatory agent by inhibiting pro-inflammatory cytokines and modulating the NF-κB signaling pathway through its primary iridoid glycosides.

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Picrorhiza kurroa (Picroside I)

PubChem CID: 119031

Picroside I is a potent iridoid glycoside that exerts hepatoprotective and immunomodulatory effects by inhibiting pro-inflammatory cytokine expression and modulating the NF-κB and MAPK signaling pathways.

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Picrorhiza kurroa (Picroside II)

PubChem CID: 5318531

Picrorhiza kurroa exerts potent hepatoprotective and immunomodulatory effects primarily through the modulation of the Nrf2/ARE antioxidant signaling pathway and inhibition of pro-inflammatory NF-κB activation.

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Pine Bark Extract (Procyanidin B1)

PubChem CID: 112501

Pine Bark Extract, standardized to oligomeric proanthocyanidins (OPCs), functions as a potent antioxidant and nitric oxide modulator by upregulating endothelial nitric oxide synthase (eNOS) activity to improve microcirculation and systemic vascular integrity.

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Piper longum (Piperine)

PubChem CID: 638024

Piper longum functions primarily as a bioenhancer and thermogenic agent by modulating TRPV1 receptors and inhibiting hepatic and intestinal glucuronidation to increase the systemic exposure of co-administered xenobiotics.

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Piper methysticum (Kavain)

PubChem CID: 10635

Piper methysticum exerts potent anxiolytic and sedative effects through the positive allosteric modulation of GABA-A receptors and the inhibition of voltage-gated sodium and calcium channels to modulate neurotransmitter release.

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Polydextrose

PubChem CID: 108967

Polydextrose is a highly branched, non-digestible synthetic polymer of glucose that functions as a prebiotic fiber and bulking agent, modulating gut microbiota composition and improving glycemic response by slowing carbohydrate absorption.

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Polygonum cuspidatum (Resveratrol)

PubChem CID: 445154

A stilbenoid polyphenol that modulates sirtuin-1 (SIRT1) activity and AMP-activated protein kinase (AMPK) signaling to enhance mitochondrial biogenesis and provide potent antioxidant protection against oxidative stress-induced cellular senescence.

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Polygonum multiflorum (2,3,5,4'-Tetrahydroxystilbene-2-O-beta-D-glucoside)

PubChem CID: 5318717

This polyphenolic stilbene glycoside functions as a potent antioxidant and neuroprotective agent by modulating the SIRT1/NF-κB signaling pathway and inhibiting α-synuclein aggregation, primarily targeted for age-related cognitive decline and cardiovascular lipid regulation.

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Pomegranate Seed Oil (Punicic Acid)

PubChem CID: 5281126

Punicic acid is a conjugated linolenic acid isomer that functions as a potent dual PPAR-alpha and PPAR-gamma agonist, exerting significant anti-inflammatory and insulin-sensitizing effects through the modulation of eicosanoid synthesis and cytokine expression.

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Poria cocos (Pachymic acid)

PubChem CID: 155583

Pachymic acid is a lanostane-type triterpenoid that exerts potent anti-inflammatory, sedative, and diuretic effects by inhibiting phospholipase A2 and modulating GABA(A) receptor chloride channel kinetics.

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Poria cocos (Pachymic acid)

PubChem CID: 155583

A lanostane-type triterpenoid derived from Poria cocos that exhibits potent anti-inflammatory, anti-tumor, and sedative properties by modulating the NF-κB pathway and GABAergic signaling.

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Porphyran (Sulfated Polysaccharide)

PubChem CID: 102213714

Porphyran is a complex sulfated carbohydrate polymer derived from red algae that functions as a potent antioxidant and immunomodulator by inhibiting pro-inflammatory cytokines and modulating lipid metabolism.

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Potassium Bicarbonate

PubChem CID: 516893

Potassium bicarbonate serves as a systemic alkalizing agent and essential electrolyte source, primarily utilized to modulate acid-base homeostasis, enhance intracellular potassium concentrations, and mitigate metabolic acidosis-induced bone resorption.

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Potassium Iodide

PubChem CID: 4875

Potassium iodide serves as a critical inorganic substrate for thyroid peroxidase-mediated iodination of tyrosine residues on thyroglobulin, facilitating the synthesis of thyroxine and triiodothyronine while providing competitive inhibition against radioiodine uptake in the thyroid gland.

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Potassium Phosphate Dibasic

PubChem CID: 24450

Potassium phosphate dibasic serves as a critical buffering agent and electrolyte source, facilitating the maintenance of intracellular acid-base homeostasis and supporting the phosphorylation of adenosine diphosphate during high-intensity metabolic demand.

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Protease (Bromelain)

PubChem CID: 16131435

Proteases are proteolytic enzymes that catalyze the hydrolysis of peptide bonds, facilitating protein digestion, systemic inflammation modulation, and fibrinolytic activity.

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Psyllium Husk (Arabinoxylan)

PubChem CID: 131751474

Psyllium husk functions as a non-fermentable, bulk-forming mucilaginous fiber that improves gastrointestinal transit and metabolic health by forming a high-viscosity gel that sequesters bile acids and slows glucose absorption.

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Pueraria lobata (Puerarin)

PubChem CID: 5281807

Puerarin, a C-glucoside isoflavone, functions as a selective modulator of alcohol dehydrogenase and a potent vasodilator through the activation of the PI3K/Akt signaling pathway, primarily utilized for managing alcohol dependence and cardiovascular microcirculation.

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Pueraria tuberosa (Puerarin)

PubChem CID: 5281807

Pueraria tuberosa acts as a potent rejuvenative and galactagogue, exerting its pharmacological effects primarily through isoflavonoid-mediated modulation of the endocrine system and glucose metabolism.

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Pullulan

PubChem CID: 91852657

Pullulan is a non-ionic, water-soluble extracellular polysaccharide produced by Aureobasidium pullulans, primarily utilized for its film-forming properties and prebiotic potential in modulating gut microbiota and improving glycemic response.

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Pyridoxal 5'-Phosphate

PubChem CID: 1051

Pyridoxal 5'-Phosphate is the metabolically active coenzyme form of Vitamin B6, serving as a critical cofactor for over 140 enzymatic reactions, primarily in amino acid metabolism, neurotransmitter synthesis, and heme biosynthesis.

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Pyrroloquinoline-quinone

PubChem CID: 1024

PQQ acts as a redox-active o-quinone coenzyme that facilitates mitochondrial biogenesis through the activation of the PGC-1α pathway and provides potent neuroprotective effects by modulating the N-methyl-D-aspartate (NMDA) receptor.

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Quercetin

PubChem CID: 5280343

Quercetin is a polyphenolic flavonoid that modulates inflammatory signaling pathways by inhibiting cyclooxygenase and lipoxygenase enzymes while exerting potent antioxidant effects through the scavenging of reactive oxygen species.

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Quercetin Dihydrate

PubChem CID: 5280343

Quercetin dihydrate is a polyphenolic flavonoid that exerts senolytic effects by inhibiting the PI3K/Akt pathway and mitigates oxidative stress through the scavenging of reactive oxygen species and chelation of transition metal ions.

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Raffinose

PubChem CID: 10542

Raffinose is a non-digestible trisaccharide that functions as a selective prebiotic, promoting the proliferation of beneficial gut microbiota while modulating glycemic response and intestinal barrier function.

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Raphanus sativus (Glucoraphasatin)

PubChem CID: 15559311

Glucoraphasatin serves as a thio-glycoside precursor to the isothiocyanate raphasatin, functioning as a potent inducer of Phase II detoxification enzymes and Nrf2-mediated antioxidant signaling to mitigate oxidative stress and hepatotoxicity.

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Raphanus sativus (Sulforaphene)

PubChem CID: 5364506

Sulforaphene functions as a potent Nrf2 transcriptional activator and phase II detoxification enzyme inducer, providing robust cytoprotection against oxidative stress and xenobiotic-induced cellular damage.

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Rehmannia glutinosa (Catalpol)

PubChem CID: 91552

Rehmannia glutinosa, primarily through its iridoid glycoside catalpol, exerts potent neuroprotective and hypoglycemic effects by modulating the PI3K/Akt signaling pathway and suppressing pro-inflammatory cytokines.

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Reishi Mushroom (Ganoderic Acid A)

PubChem CID: 15558242

Reishi mushroom extract functions as a potent immunomodulator and adaptogen by leveraging ganoderic acids and beta-glucans to regulate cytokine production and enhance macrophage activity via the NF-κB and MAPK signaling pathways.

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Reishi Mushroom (Ganoderic acid A)

PubChem CID: 15558230

Ganoderic acid A is a highly oxygenated lanostane-type triterpenoid derived from Ganoderma lucidum that exerts potent anti-inflammatory and hepatoprotective effects through the inhibition of NF-κB signaling and modulation of farnesoid X receptor (FXR) activity.

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Resistant Maltodextrin (Soluble Gluco-oligosaccharide)

PubChem CID: 62698

Resistant maltodextrin acts as a fermentable prebiotic fiber that modulates postprandial glycemic response and enhances colonic microflora diversity through the production of short-chain fatty acids.

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Resistant Starch (Amylose)

PubChem CID: 53477771

Resistant starch functions as a prebiotic fiber that evades upper gastrointestinal enzymatic hydrolysis to undergo colonic fermentation, producing short-chain fatty acids like butyrate that modulate glycemic response and enhance mucosal barrier integrity.

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Resveratrol

PubChem CID: 445154

Resveratrol is a polyphenolic phytoalexin that modulates sirtuin-1 (SIRT1) activity and AMP-activated protein kinase (AMPK) signaling to enhance mitochondrial biogenesis and provide potent antioxidant protection against oxidative stress-induced cellular senescence.

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Retinyl Palmitate

PubChem CID: 445354

A preformed Vitamin A ester that undergoes enzymatic hydrolysis to retinol and subsequent oxidation to retinoic acid, primarily utilized for epidermal cell turnover, collagen synthesis, and visual cycle maintenance.

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Rheum palmatum (Emodin)

PubChem CID: 3220

Emodin is a bioactive anthraquinone that modulates the NF-κB and MAPK signaling pathways to exert potent anti-inflammatory, pro-apoptotic, and laxative effects via the activation of chloride secretion in the colonic mucosa.

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Rhodiola Rosea (Salidroside)

PubChem CID: 159244

Rhodiola rosea functions as a potent adaptogen by modulating the hypothalamic-pituitary-adrenal axis and inhibiting monoamine oxidase A and B to enhance cellular resilience against physical and cognitive stressors.

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Rhodiola rosea (Salidroside)

PubChem CID: 159249

Rhodiola rosea acts as a potent adaptogen by modulating the hypothalamic-pituitary-adrenal (HPA) axis and inhibiting monoamine oxidase to enhance cellular resilience against physical and cognitive stressors.

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Riboflavin 5'-Phosphate

PubChem CID: 439183

Riboflavin 5'-Phosphate serves as a direct precursor to the essential redox cofactors flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), playing a pivotal role in mitochondrial bioenergetics and the metabolism of fats, drugs, and steroids.

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Rice Bran (Glucosylceramides)

PubChem CID: 9851116

Glucosylceramides function as essential precursors to skin ceramides, modulating the epidermal permeability barrier and reducing transepidermal water loss (TEWL) through the upregulation of endogenous sphingolipid synthesis.

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Rosmarinic Acid

PubChem CID: 5281792

Rosmarinic acid is a polyphenolic carboxylic acid that exerts potent antioxidant and anti-inflammatory effects by modulating the Nrf2 signaling pathway and inhibiting cyclooxygenase-2 (COX-2) activity.

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Rosmarinus officinalis (Carnosic acid)

PubChem CID: 65126

Carnosic acid is a lipophilic phenolic diterpene that exerts potent antioxidant and neuroprotective effects by activating the Nrf2/ARE pathway and inhibiting pro-inflammatory cytokines like TNF-α and IL-1β.

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Rubia cordifolia (Alizarin)

PubChem CID: 6293

Rubia cordifolia functions as a potent dermatological and anti-inflammatory agent by modulating NF-κB and MAPK signaling pathways to reduce oxidative stress and inhibit pro-inflammatory cytokine production.

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Rubidium Chloride

PubChem CID: 2724288

Rubidium chloride acts as a monovalent cation analogue to potassium, modulating neuronal excitability and neurotransmitter release, primarily investigated for its potential antidepressant effects through the enhancement of monoaminergic transmission.

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Rutin

PubChem CID: 5280805

Rutin is a flavonol glycoside that exerts potent vasoprotective and antioxidant effects by inhibiting protein disulfide isomerase (PDI) and reducing capillary permeability.

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S-Adenosyl-L-Methionine (SAMe)

PubChem CID: 34755

SAMe serves as the primary methyl donor in the transmethylation cycle, critical for the synthesis of monoamine neurotransmitters, membrane phospholipids, and the maintenance of hepatic glutathione levels through the transsulfuration pathway.

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S-Adenosyl-L-methionine (SAMe)

PubChem CID: 34755

A critical universal methyl donor involved in the synthesis of neurotransmitters, phospholipids, and DNA, primarily utilized for its antidepressant, hepatoprotective, and chondroprotective properties.

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S-Adenosyl-L-methionine Disulfate Tosylate (SAMe)

PubChem CID: 34755

A critical universal methyl donor that facilitates the synthesis of neurotransmitters, phospholipids, and proteoglycans through the methionine cycle to support cognitive function and joint structural integrity.

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Saccharomyces cerevisiae (Beta-1,3/1,6-D-Glucan)

PubChem CID: 439261

This yeast-derived polysaccharide functions as a biological response modifier by binding to Dectin-1 receptors on macrophages and neutrophils, thereby priming the innate immune system without inducing pro-inflammatory cytokine overproduction.

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Saffron (Crocetin)

PubChem CID: 5281232

Crocetin is a natural carotenoid dicarboxylic acid that facilitates increased oxygen diffusion in plasma and modulates NMDA receptor activity, primarily targeted for neuroprotective and cardiovascular applications.

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Saffron (Crocin)

PubChem CID: 5281233

A water-soluble carotenoid glycoside that exerts potent neuroprotective, antidepressant, and antioxidant effects by modulating NMDA receptor signaling and inhibiting the reuptake of monoamine neurotransmitters.

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Salvia miltiorrhiza (Tanshinone IIA)

PubChem CID: 164676

Tanshinone IIA is a lipophilic diterpenoid quinone that exerts potent cardioprotective and anti-inflammatory effects primarily through the modulation of the PI3K/Akt/mTOR signaling pathway and inhibition of NF-κB activation.

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Sambucus nigra (Cyanidin-3-glucoside)

PubChem CID: 441667

Cyanidin-3-glucoside functions as a potent anthocyanin modulator of the innate immune response by inhibiting viral attachment and suppressing pro-inflammatory cytokine expression through the modulation of NF-κB and MAPK signaling pathways.

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Saw Palmetto Berry Extract (Beta-Sitosterol)

PubChem CID: 222284

Saw Palmetto Berry Extract functions primarily as a liposterolic inhibitor of 5-alpha-reductase, modulating the conversion of testosterone to dihydrotestosterone to support prostate health and mitigate androgenetic alopecia.

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Schisandra Berry Extract (Schisandrins)

PubChem CID: 155256

Schisandra chinensis lignans function as potent adaptogens by modulating the hypothalamic-pituitary-adrenal axis and upregulating cytoprotective heat shock proteins and antioxidant enzymes such as glutathione peroxidase.

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Schisandra chinensis (Schisandrin B)

PubChem CID: 115241

Schisandrin B functions as a potent dibenzocyclooctadiene lignan that modulates the Nrf2/ARE signaling pathway to enhance mitochondrial glutathione redox status and provide robust hepatoprotective and neuroprotective effects against oxidative stress.

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Schisandra chinensis (Schisandrin)

PubChem CID: 155256

Schisandra chinensis functions as a potent adaptogen and hepatoprotectant by modulating the HPA axis and upregulating phase II detoxification enzymes via the Nrf2/ARE signaling pathway.

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Scutellaria baicalensis (Baicalin)

PubChem CID: 5281605

A flavone glycoside that modulates GABA-A receptors and inhibits pro-inflammatory cytokines via NF-κB pathway suppression, primarily utilized for neuroprotection and systemic anti-inflammatory applications.

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Scutellaria baicalensis (Baicalin)

PubChem CID: 5281037

Baicalin is a flavone glycoside that modulates GABA-A receptors and inhibits pro-inflammatory cytokines via the NF-κB pathway, offering potent neuroprotective and anti-inflammatory therapeutic potential.

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Scutellaria lateriflora (Baicalin)

PubChem CID: 5281505

Scutellaria lateriflora functions as a potent anxiolytic and neuroprotective agent primarily through the positive allosteric modulation of the GABA-A receptor benzodiazepine site, facilitating chloride ion influx to attenuate neuronal excitability.

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Senna Leaf Extract (Sennosides)

PubChem CID: 5281314

Senna leaf extract functions as a stimulant laxative by undergoing bacterial hydrolysis in the colon to release active rheinanthrones, which increase peristaltic contractions and alter electrolyte transport to induce defecation.

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Silybum marianum (Silybin)

PubChem CID: 31553

Silybin functions as a hepatoprotective agent by modulating the NF-κB signaling pathway, stimulating ribosomal RNA polymerase I to accelerate protein synthesis, and acting as a free radical scavenger to mitigate lipid peroxidation in hepatic membranes.

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Silybum marianum (Silybin)

PubChem CID: 31553

Silybin acts as a hepatoprotective flavonolignan that modulates nuclear factor kappa B (NF-κB) signaling and enhances protein synthesis in hepatocytes by stimulating RNA polymerase I activity, thereby facilitating hepatic regeneration and mitigating oxidative stress-induced lipoperoxidation.

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Siphonaxanthin

PubChem CID: 5281251

Siphonaxanthin is a marine keto-carotenoid found in green algae that exhibits potent anti-angiogenic, anti-inflammatory, and pro-apoptotic activities by modulating the expression of Bcl-2 family proteins and inhibiting FGF-2-induced signaling pathways.

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Skullcap Extract (Baicalin)

PubChem CID: 5281605

Skullcap extract functions primarily as a positive allosteric modulator of the GABA-A receptor's benzodiazepine site, exerting potent anxiolytic, neuroprotective, and anti-inflammatory effects through the inhibition of pro-inflammatory cytokines and oxidative stress pathways.

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Slippery Elm Bark (D-Galacturonic Acid)

PubChem CID: 68574

Slippery Elm Bark functions as a potent demulcent agent, utilizing its high mucilage content to form a protective physical barrier over inflamed gastrointestinal and respiratory mucosa, thereby mitigating mechanical irritation and promoting epithelial recovery.

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Sodium Hyaluronate

PubChem CID: 23663391

Sodium hyaluronate is a high-molecular-weight glycosaminoglycan that functions as a humectant and viscoelastic lubricant, facilitating tissue hydration and joint lubrication via interaction with CD44 receptors and the extracellular matrix.

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Sodium Molybdate

PubChem CID: 24884

Sodium molybdate serves as a highly bioavailable source of molybdenum, an essential trace element functioning as a redox-active cofactor for enzymes including sulfite oxidase, xanthine oxidase, and aldehyde oxidase involved in sulfur amino acid metabolism and purine catabolism.

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Sodium Selenite

PubChem CID: 24932

Sodium selenite serves as a highly bioavailable inorganic selenium source that functions as a mandatory cofactor for glutathione peroxidase and thioredoxin reductase enzymes, essential for maintaining cellular redox homeostasis and thyroid hormone deiodination.

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Solanum nigrum (Solamargine)

PubChem CID: 73611

Solamargine is a steroidal glycoalkaloid that exerts potent antineoplastic activity by inducing apoptosis through the upregulation of TNFRSF1A and TNFRSF1B, while also demonstrating significant hepatoprotective and anti-inflammatory properties.

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Sophora flavescens (Matrine)

PubChem CID: 91466

A quinolizidine alkaloid that exerts potent anti-inflammatory and hepatoprotective effects by inhibiting the NF-κB signaling pathway and modulating TGF-β/Smad expression to mitigate fibrotic progression.

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Spermidine Trihydrochloride

PubChem CID: 74888

Spermidine trihydrochloride acts as a potent polyamine mimetic that induces macroautophagy through the inhibition of the acetyltransferase EP300, thereby promoting cellular proteostasis and systemic longevity.

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Sphingomyelin

PubChem CID: 53474933

Sphingomyelin is a primary phosphosphingolipid of the myelin sheath that regulates signal transduction and cognitive development by facilitating lipid raft formation and serving as a metabolic precursor to bioactive ceramides.

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Spirulina (Phycocyanobilin)

PubChem CID: 5352130

Spirulina functions as a potent antioxidant and immunomodulator primarily through phycocyanobilin-mediated inhibition of NADPH oxidase and selective scavenging of hydroxyl and peroxyl radicals.

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Spirulina Extract (Phycocyanobilin)

PubChem CID: 5281895

Phycocyanobilin acts as a potent tetrapyrrole chromophore that mimics bilirubin's inhibitory effect on NADPH oxidase (NOX) complexes, providing significant cytoprotective and anti-inflammatory activity across cardiovascular and neurological tissues.

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Squalene

PubChem CID: 638072

Squalene is a triterpene hydrocarbon and natural antioxidant that serves as a precursor to sterol synthesis, primarily utilized for its skin-protective, immunomodulatory, and lipid-regulating properties.

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St. John's Wort (Hypericin)

PubChem CID: 5281023

St. John's Wort extract functions as a broad-spectrum monoamine reuptake inhibitor, primarily modulating serotonin, dopamine, and norepinephrine levels through the inhibition of synaptosomal uptake to alleviate mild-to-moderate depressive symptoms.

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Stachyose

PubChem CID: 439531

Stachyose is a non-reducing tetrasaccharide prebiotic that selectively modulates the gut microbiome by promoting the proliferation of Bifidobacterium and Lactobacillus species, thereby enhancing the production of short-chain fatty acids and improving intestinal barrier function.

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Stannous Chloride

PubChem CID: 24479

Stannous chloride functions primarily as a potent reducing agent and essential precursor in the preparation of technetium-99m radiopharmaceuticals, while also serving as a specialized source of divalent tin for trace mineral metabolic studies.

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Stearidonic Acid

PubChem CID: 5282847

Stearidonic acid is an omega-3 fatty acid that acts as a metabolic intermediate between alpha-linolenic acid and eicosapentaenoic acid, bypassing the rate-limiting delta-6 desaturase enzyme to efficiently elevate systemic EPA levels and modulate pro-inflammatory eicosanoid synthesis.

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Stigmasterol

PubChem CID: 5280794

Stigmasterol is a phytosterol that modulates cholesterol metabolism by inhibiting intestinal absorption and exhibits anti-inflammatory properties through the inhibition of pro-inflammatory cytokines and matrix metalloproteinases.

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Strontium Citrate

PubChem CID: 16218641

Strontium citrate acts as a dual-action bone-seeking agent that simultaneously stimulates osteoblast-mediated bone formation and inhibits osteoclast-mediated resorption by activating the calcium-sensing receptor (CaSR).

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Superoxide Dismutase

PubChem CID: 131751167

Superoxide dismutase is a critical metalloenzyme that catalyzes the dismutation of superoxide radicals into oxygen and hydrogen peroxide, providing a primary enzymatic defense against oxidative stress and systemic inflammation.

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Taraxacum officinale (Taraxasterol)

PubChem CID: 73556

Taraxasterol is a pentacyclic triterpene that exerts potent anti-inflammatory and hepatoprotective effects by modulating the NF-κB and Nrf2 signaling pathways, primarily utilized in managing metabolic and hepatic disorders.

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Tart Cherry Extract (Cyanidin-3-glucoside)

PubChem CID: 441667

Tart cherry extract functions as a potent modulator of oxidative stress and systemic inflammation by inhibiting cyclooxygenase enzymes and providing exogenous melatonin to enhance exercise recovery and circadian rhythm regulation.

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Taurine

PubChem CID: 597

Taurine is a sulfur-containing semi-essential amino acid that functions as an intracellular osmolyte and neuromodulator, primarily facilitating bile acid conjugation, calcium signaling stabilization, and cytoprotection against oxidative stress in cardiac and neural tissues.

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Taxifolin (Dihydroquercetin)

PubChem CID: 439533

Taxifolin is a pentahydroxyflavanone that functions as a potent antioxidant and anti-inflammatory agent by modulating the Nrf2/HO-1 pathway and inhibiting pro-inflammatory cytokine production.

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Terminalia arjuna (Arjunolic Acid)

PubChem CID: 73641

Terminalia arjuna functions as a potent cardiotonic agent by modulating myocardial contractility and enhancing antioxidant defense mechanisms through the upregulation of endogenous enzymes like superoxide dismutase and catalase.

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Terminalia bellirica (Belleric acid)

PubChem CID: 119031

Terminalia bellirica functions as a potent xanthine oxidase inhibitor and hepatoprotective agent, primarily utilized for the management of hyperuricemia and oxidative stress-induced hepatic dysfunction.

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Terminalia bellirica (Gallic Acid)

PubChem CID: 370

A potent hydrolyzable tannin source primarily utilized for its hepatoprotective, antioxidant, and metabolic regulatory properties through the modulation of oxidative stress pathways and lipid metabolism.

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Terminalia chebula (Chebulic acid)

PubChem CID: 440704

Chebulic acid functions as a potent hepatoprotective and antioxidant agent by modulating oxidative stress pathways and inhibiting pro-inflammatory cytokines through the neutralization of reactive oxygen species and the induction of endogenous antioxidant enzymes.

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Terminalia chebula (Chebulinic Acid)

PubChem CID: 104741

Terminalia chebula acts as a potent antioxidant and prokinetic agent, primarily utilized for its cytoprotective effects on the gastrointestinal mucosa and its ability to modulate oxidative stress via the inhibition of lipid peroxidation.

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Terminalia chebula (Chebulinic acid)

PubChem CID: 72384

Terminalia chebula functions as a potent hepatoprotective and antioxidant agent by modulating the Nrf2/ARE pathway and inhibiting pro-inflammatory cytokines through its primary hydrolyzable tannin, chebulinic acid.

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Thiamine Hydrochloride

PubChem CID: 1130

Thiamine hydrochloride acts as a critical enzymatic cofactor for the pyruvate dehydrogenase complex and alpha-ketoglutarate dehydrogenase, facilitating oxidative decarboxylation in the Krebs cycle to support cellular energy metabolism and neurological function.

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Tilia cordata (Tiliroside)

PubChem CID: 5316410

Tilia cordata functions primarily as a mild sedative and anxiolytic agent by modulating GABAergic signaling and exerting anti-inflammatory effects through the inhibition of pro-inflammatory cytokines and oxidative stress markers.

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Tinospora cordifolia (Tinosporaside)

PubChem CID: 11463614

Tinospora cordifolia exerts potent immunomodulatory and hepatoprotective effects by modulating the NF-κB signaling pathway and enhancing macrophage activity through the activation of Th1-type immune responses.

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Tinospora cordifolia (Tinosporoside)

PubChem CID: 11234034

Tinospora cordifolia functions as a potent immunomodulator and hepatoprotective agent by modulating the NF-κB signaling pathway and enhancing macrophage activity through TLR4 activation.

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Tomato Extract (Lycopene)

PubChem CID: 446925

Lycopene is a lipophilic tetraterpene carotenoid that functions as a potent singlet oxygen quencher and antioxidant, primarily utilized for prostate health support and systemic photoprotection.

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Tongkat Ali (Eurycomanone)

PubChem CID: 155455

Tongkat Ali extract functions as a pro-androgenic phytotherapeutic agent by modulating the hypothalamic-pituitary-gonadal axis and inhibiting aromatase activity to optimize free testosterone levels and enhance ergogenic performance.

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Trametes versicolor (Polysaccharide-K)

PubChem CID: 11966249

Polysaccharide-K functions as a proteoglycan-based biological response modifier that enhances T-cell mediated cytotoxicity and modulates innate immunity through the activation of Toll-like receptor 2 (TLR2) signaling pathways.

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Trans-Resveratrol

PubChem CID: 445154

A polyphenolic phytoalexin that modulates sirtuin-1 (SIRT1) activity and AMPK pathways to enhance mitochondrial biogenesis and provide potent antioxidant protection against oxidative stress-induced cellular senescence.

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Tribulus Terrestris (Protodioscin)

PubChem CID: 115167

Tribulus terrestris functions as a steroidal saponin-rich botanical that modulates androgen receptor density and nitric oxide signaling to enhance libido and erectile function without significantly altering baseline serum testosterone levels.

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Tribulus terrestris (Protodioscin)

PubChem CID: 119244

Protodioscin acts as a steroidal saponin precursor that enhances androgen receptor density and stimulates the release of luteinizing hormone to support libido and erectile function.

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Turmeric (Curcumin)

PubChem CID: 969516

Curcumin is a pleiotropic polyphenolic compound that modulates multiple signaling pathways, including NF-κB and Nrf2, to exert potent anti-inflammatory and antioxidant effects in systemic metabolic and musculoskeletal pathologies.

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Ubiquinone (Coenzyme Q10)

PubChem CID: 5281915

Ubiquinone functions as a critical lipophilic electron carrier in the mitochondrial respiratory chain, facilitating ATP synthesis through oxidative phosphorylation while mitigating oxidative stress via the neutralization of lipid peroxyl radicals.

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Ulva lactuca (Ulvan)

PubChem CID: 131751336

Ulvan is a sulfated heteropolysaccharide derived from green macroalgae that exerts immunomodulatory, antioxidant, and antiviral effects through the modulation of cytokine pathways and inhibition of viral adsorption.

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Uncaria tomentosa (Mitraphylline)

PubChem CID: 441975

Mitraphylline acts as a potent immunomodulator and anti-inflammatory agent by inhibiting the NF-κB signaling pathway and modulating the production of pro-inflammatory cytokines such as TNF-α and IL-6.

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Valerian Root (Valerenic Acid)

PubChem CID: 6440907

Valerian root extract functions primarily as a GABAergic modulator by inhibiting the enzymatic breakdown of gamma-aminobutyric acid via GABA transaminase and acting as a partial agonist at GABA-A receptors to induce anxiolysis and sedative effects.

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Valeriana officinalis (Valerenic Acid)

PubChem CID: 6440931

Valeriana officinalis functions as a positive allosteric modulator of GABA-A receptors, specifically targeting the beta-3 subunit to induce anxiolysis and enhance sleep architecture by inhibiting the enzymatic breakdown of gamma-aminobutyric acid.

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Vanadyl Sulfate

PubChem CID: 61508

Vanadyl sulfate functions as a potent insulin-mimetic agent by inhibiting protein tyrosine phosphatases, thereby enhancing insulin receptor autophosphorylation and facilitating GLUT4 translocation for improved peripheral glucose disposal.

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Verbascose

PubChem CID: 441434

Verbascose is a non-digestible alpha-galactooligosaccharide that serves as a selective prebiotic substrate for colonic microflora, though its fermentation kinetics require careful management to avoid osmotic diarrhea and flatulence.

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Verbena officinalis (Verbenalin)

PubChem CID: 119594

Verbena officinalis functions primarily as a neuroprotective and galactagogue agent, exerting its effects through the modulation of GABAergic signaling and the inhibition of pro-inflammatory cytokines such as TNF-α and IL-6.

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Violaxanthin

PubChem CID: 5281250

Violaxanthin is a natural xanthophyll carotenoid that functions as a potent antioxidant and photoprotective agent, primarily investigated for its role in the xanthophyll cycle and its potential anti-inflammatory and anti-proliferative effects in human skin and ocular tissues.

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Vitis vinifera (Resveratrol)

PubChem CID: 445154

Resveratrol functions as a potent sirtuin-1 (SIRT1) activator and polyphenolic antioxidant that modulates mitochondrial biogenesis and cardiovascular hemodynamics through the activation of the AMPK pathway.

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White Willow Bark (Salicin)

PubChem CID: 439503

White willow bark extract acts as a natural precursor to salicylic acid, exerting anti-inflammatory and analgesic effects through the non-selective inhibition of cyclooxygenase (COX-1 and COX-2) enzymes to modulate pro-inflammatory cytokine production.

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White Willow Bark (Salicin)

PubChem CID: 439503

Salicin acts as a non-selective cyclooxygenase inhibitor precursor that undergoes metabolic conversion to salicylic acid in the lower intestine and liver to exert prolonged analgesic and anti-inflammatory effects with a lower risk of acute gastric mucosal injury compared to synthetic aspirin.

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White Willow Bark (Salicin)

PubChem CID: 439503

Salicin is an alcoholic β-glucoside prodrug that undergoes intestinal and hepatic metabolism into salicylic acid, providing systemic analgesic and anti-inflammatory effects through non-selective cyclooxygenase inhibition and modulation of pro-inflammatory cytokine signaling.

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Wild Lettuce (Lactucin)

PubChem CID: 119144

Lactuca virosa functions primarily as a mild sedative and analgesic via the modulation of adenosine receptors and potential inhibition of enkephalinase, making it a candidate for non-opioid pain management and sleep induction.

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Withania somnifera (Withaferin A)

PubChem CID: 265237

Withania somnifera functions as a potent adaptogen by modulating the hypothalamic-pituitary-adrenal (HPA) axis and exerting GABAergic mimetic effects to attenuate cortisol-induced physiological stress responses.

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Withania somnifera (Withaferin A)

PubChem CID: 265237

Withaferin A, a steroidal lactone derived from Withania somnifera, functions as a potent proteasome inhibitor and modulator of heat shock proteins, primarily utilized for its adaptogenic, anti-inflammatory, and pro-apoptotic properties in oncological and neuroprotective contexts.

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Xylanase (Endo-1,4-beta-xylanase)

PubChem CID: 11966277

Xylanase is a glycoside hydrolase that catalyzes the endohydrolysis of 1,4-beta-D-xylosidic linkages in xylans, facilitating the breakdown of hemicellulose into xylo-oligosaccharides to improve nutrient bioavailability and reduce digesta viscosity in the gastrointestinal tract.

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Xylo-oligosaccharides (Xylobiose)

PubChem CID: 439191

Xylo-oligosaccharides function as selective prebiotics that modulate the gut microbiota by promoting the growth of Bifidobacterium species and enhancing the production of short-chain fatty acids to improve metabolic and immunological health.

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Xylooligosaccharides (Xylobiose)

PubChem CID: 439191

Xylooligosaccharides function as potent prebiotic fibers that selectively stimulate the proliferation of Bifidobacterium species in the colon, thereby modulating the gut-brain axis and enhancing short-chain fatty acid production.

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Zeaxanthin

PubChem CID: 5280899

Zeaxanthin is a xanthophyll carotenoid that selectively accumulates in the macula lutea to provide photoprotection against high-energy blue light and neutralize reactive oxygen species via its conjugated double-bond system.

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Zinc Gluconate

PubChem CID: 443435

Zinc gluconate serves as a highly bioavailable organic salt that provides elemental zinc to act as a critical catalytic and structural cofactor for over 300 enzymes, primarily influencing nucleic acid synthesis and T-lymphocyte maturation.

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Zinc Monomethionine

PubChem CID: 16212486

A chelated mineral complex designed to enhance zinc bioavailability and plasma retention through the L-methionine transport pathway, primarily utilized for immune modulation and dermatological health.

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Zinc Picolinate

PubChem CID: 151924

Zinc picolinate is a highly bioavailable chelated form of elemental zinc that functions as a critical cofactor for over 300 enzymes, primarily targeting immune modulation, DNA synthesis, and cellular signaling pathways.

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Zingiber officinale (6-Gingerol)

PubChem CID: 442431

A phenolic phytocompound that modulates pro-inflammatory cytokines and inhibits COX-2 enzymes to provide potent anti-emetic and systemic anti-inflammatory effects.

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Zingiber officinale ([6]-Gingerol)

PubChem CID: 442430

Zingiber officinale exerts potent anti-emetic and anti-inflammatory effects primarily through the modulation of 5-HT3 receptors and the inhibition of cyclooxygenase (COX) and lipoxygenase (LOX) pathways.

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Ziziphus jujuba (Jujuboside A)

PubChem CID: 11211154

A dammarane-type triterpene saponin that modulates the GABAergic system and inhibits glutamate-mediated excitatory signaling to exert potent sedative, anxiolytic, and neuroprotective effects.

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Ziziphus jujuba (Jujuboside A)

PubChem CID: 11211718

Ziziphus jujuba exerts sedative and anxiolytic effects primarily through the modulation of GABAergic signaling and the inhibition of excitatory glutamate pathways within the hippocampal CA1 region.

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d-Alpha Tocopheryl Acetate

PubChem CID: 86472

As a stabilized ester of alpha-tocopherol, this lipid-soluble compound functions as a potent chain-breaking antioxidant that protects polyunsaturated fatty acids within cellular membranes from oxidative degradation by scavenging lipid peroxyl radicals.

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