Sample Reports

Cross-formulation PK comparison across 7 delivery formats at 25 mg dose. Buccal strips deliver 22-78% CBD (higher than sublingual) vs <2% for swallowed formats while fasted — a 40× gap. Food boosts oral formats 3-5× but barely matters for transmucosal routes. CBN outpaces CBD by 8-16% in transmucosal delivery but CBD outpaces CBN in oral delivery.

PBPK simulation validated against Jäger et al. 2014 clinical data — Hydrophilic Carrier ASD delivers 48.3× more bioavailability than crystalline powder (clinical: 45.9×), while Phytosome achieves 5.5× (clinical: 7.9×).

Population-level pharmacokinetics for seven bioactives across Fenugreek and Shatavari extracts, comparing general adults vs. menopausal Asian women (45–55y) with cross-extract DDI analysis.

PBPK simulation validating the 17× bioavailability boost from transbuccal delivery (60.5% F) over oral powder suspension (3.6% F) — matching Bojanowski et al.'s clinical observation of 15× enhancement. 97% of dose absorbed transmucosally, bypassing first-pass metabolism entirely.

The "natural GLP-1" that barely survives digestion — PBPK simulation across 5 delivery arms reveals berberine's permanent positive charge blocks both food effects and buccal delivery, making piperine co-administration in a capsule a 2.8× boost and buccal strips a dose-constrained dead end.

PBPK quantification of the 2.9× bioenhancement from co-extracted flavonoids on andrographolide (10% → 29.2% F), showing that intrinsic extract synergy dominates over piperine's modest 1.05× additional lift.

Formulaite stability predictions benchmarked against Kharat et al. 2020 for curcumin retention in oil-in-water emulsions. The model matches the primary antioxidant ranking from literature: Trolox > Ascorbic acid > Ascorbyl palmitate > No antioxidant, with 6/6 pairwise agreement and pathway-level explanation of radical autoxidation suppression.

Arrhenius-based shelf-life predictions across five branded curcumin products (C3+BioPerine, BCM-95, Meriva, Longvida, CurcuWIN) under ICH long-term, intermediate, and accelerated conditions with multiple packaging formats.