Sample Reports

Combined PK/PD simulation comparing Formulaite Metabolic Support against a representative metabolic formula in an Asian adult overweight/obese virtual cohort. The model links target-site exposure, IC50/EC50 engagement, and docking de-risking to score mechanism-level support. Formulaite shows broader modeled coverage, including carb absorption support and GLP-1/GIP release & satiety signaling support.

Study-matched PBPK simulation predicts 54.2× higher dose-normalized bioavailability for hydrophilic carrier ASD versus crystalline powder, and 8.8× for phytosome. These results are close to Jäger et al. 2014 clinical benchmarks of 45.9× and 7.9×, respectively.

PBPK simulation validated against Hermush et al. 2025 — Capsoil self-nanoemulsifying powder achieves 2.28× THC and 2.26× CBD AUC vs MCT tincture control (clinical: 2.86×, 2.27×), with faster onset and 2.5× higher Cmax for THC, 2.7× for CBD from droplet-size–driven lipolysis and lymphatic uptake modeling.

Population-level pharmacokinetics for seven bioactives across Fenugreek and Shatavari extracts, comparing general adults vs. menopausal Asian women (45–55y) with cross-extract DDI analysis.

Cross-formulation PK comparison across 7 delivery formats at 25 mg dose. Buccal strips deliver 22-78% CBD (higher than sublingual) vs <2% for swallowed formats while fasted — a 40× gap. Food boosts oral formats 3-5× but barely matters for transmucosal routes. CBN outpaces CBD by 8-16% in transmucosal delivery but CBD outpaces CBN in oral delivery.

PBPK simulation across 100 virtual adults predicts 21.5% bioavailability for a 34 mg buccal strip versus 0.5% for a 2 g oral powder suspension—a 42× enhancement. Dose-normalized exposure at 2 hours is 13.3× higher, closely matching the approximately 15× clinical observation.

The "natural GLP-1" that barely survives digestion — PBPK simulation across 5 delivery arms reveals berberine's permanent positive charge blocks both food effects and buccal delivery, making piperine co-administration in a capsule a 2.8× boost and buccal strips a dose-constrained dead end.

PBPK quantification of the 2.9× bioenhancement from co-extracted flavonoids on andrographolide (10% → 29.2% F), showing that intrinsic extract synergy dominates over piperine's modest 1.05× additional lift.

Quantum-chemistry-informed stability modeling reproduces 9/10 pairwise retention comparisons from Kharat et al. 2020, including the complete 6/6 protector ranking. Trolox performs best, while α-tocopherol is not recommended for this oil-in-water system because it remains oil-phase limited.

Arrhenius-based shelf-life predictions across five branded curcumin products (C3+BioPerine, BCM-95, Meriva, Longvida, CurcuWIN) under ICH long-term, intermediate, and accelerated conditions with multiple packaging formats.

Computational PD target validation testing whether reported Sphenocentrum jollyanum marker compounds explain reproductive and aphrodisiac biology, benchmarking PDE5A, CYP19A1/aromatase, SRD5A2/5-alpha-reductase, and Tongkat Ali controls. Findings prioritize CYP19A1 and SRD5A2 assay follow-up instead of a Viagra-like PDE5A mechanism.