Alpha-Cyclodextrin

Accelerate your CDMO or DTC pipeline. Map the exact physiochemical constraints, bioavailability synergies, and optimal delivery mechanisms for Alpha-Cyclodextrin.

A cyclic oligosaccharide composed of six glucose units that functions as a molecular encapsulant to improve the solubility, stability, and bioavailability of lipophilic compounds through the formation of inclusion complexes.

Verified Molecular Profiling (NIH PubChem)

PubChem CID

444913

Molecular Weight

972.8 g/mol

XLogP3 (Lipophilicity)

-12.9

IUPAC Name

(1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23R,25R,26S,28R,30R,31R,32R,33R,34R,35R,36R,37R,38R,39R,40R,41R,42R)-5,10,15,20,25,30-hexakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29-dodecaoxaheptacyclo[26.2.2.23,6.28,11.213,16.218,21.223,26]dotetracontane-31,32,33,34,35,36,37,38,39,40,41,42-dodecol

Pharmacokinetic Synergies & Enhancers

Proven Synergy Pairings

Curcumin for increased aqueous solubility and metabolic stability
Coenzyme Q10 for enhanced intestinal absorption via inclusion complexation

Biological Formulation Enhancers

Polysorbate 80 for synergistic micellar solubilization in lipid-based systems
Hydroxypropyl Methylcellulose (HPMC) for stabilizing supersaturated states in the gastrointestinal tract

Delivery System Constraints & Modeling

Every active compound behaves uniquely based on the physical matrix it is suspended in. Below are the known physical chemistry challenges for Alpha-Cyclodextrin across standard consumer modalities.

💊 Standard Capsules

High hygroscopicity may lead to moisture-induced clumping or shell brittleness if not stored in low-humidity environments.

🍬 Gummy & Pectin Formats

The high molecular weight and required dosage levels can significantly alter the pectin gel matrix, potentially leading to a grainy texture or syneresis.

🔬 Thin-Film Oral Strips

Limited payload capacity of thin films restricts the use of alpha-cyclodextrin to low-dose active ingredients due to the high host-to-guest molar ratios required.

For Brand Founders

Formulate with Alpha-Cyclodextrin

Ready to launch a product featuring Alpha-Cyclodextrin? Skip months of expensive wet-lab iterations. Generate a manufacturer-ready formulation in hours, instantly screened for physical incompatibilities and global regulatory compliance.

Build Science-Backed Formulation

Efficacy Evidence

Maximize Alpha-Cyclodextrin Bioavailability

Need absolute proof that your Alpha-Cyclodextrin extract actually absorbs? Stop blindly combining generic powders. Run a physics-based PBPK simulation to mathematically engineer peak clinical efficacy and targeted plasma concentrations.

Simulate Bioavailability

For R&D Labs & CDMOs

Alpha-Cyclodextrin Degradation Testing

Is your Alpha-Cyclodextrin payload degrading in the capsule before the expiration date? Stop waiting for costly bench testing. Run an accelerated digital twin to precisely model oxidation pathways and pH shifts before finalizing a manufacturing run.

Model Active Degradation