Arctium lappa (Arctiin)

Accelerate your CDMO or DTC pipeline. Map the exact physiochemical constraints, bioavailability synergies, and optimal delivery mechanisms for Arctium lappa (Arctiin).

Arctiin, a lignan glycoside derived from Arctium lappa, functions as a potent anti-inflammatory and antiproliferative agent by modulating the NF-κB and MAP kinase signaling pathways while exhibiting significant antioxidant capacity through the scavenging of reactive oxygen species.

Verified Molecular Profiling (NIH PubChem)

PubChem CID

115098

Molecular Weight

721.9 g/mol

XLogP3 (Lipophilicity)

-9.2

IUPAC Name

(2S)-2-amino-5-[[(4R,23R)-4-[[(4S)-4-amino-4-carboxybutanoyl]amino]-5,8,19,22-tetraoxo-1,2-dithia-6,9,13,18,21-pentazacyclotetracos-23-yl]amino]-5-oxopentanoic acid

Pharmacokinetic Synergies & Enhancers

Proven Synergy Pairings

Luteolin for synergistic inhibition of pro-inflammatory cytokines such as IL-6 and TNF-α
Quercetin for enhanced induction of apoptosis in neoplastic cell lines via mitochondrial pathways

Biological Formulation Enhancers

Piperine for inhibition of hepatic glucuronidation to increase the systemic bioavailability of the aglycone arctigenin
Hydroxypropyl-beta-cyclodextrin for improving the aqueous solubility and dissolution rate of the lignan scaffold

Delivery System Constraints & Modeling

Every active compound behaves uniquely based on the physical matrix it is suspended in. Below are the known physical chemistry challenges for Arctium lappa (Arctiin) across standard consumer modalities.

💊 Standard Capsules

The hygroscopic nature of concentrated Arctium extracts requires moisture-resistant excipients and low-humidity manufacturing environments to prevent powder caking.

🍬 Gummy & Pectin Formats

The inherent bitterness of high-purity Arctiin requires complex organoleptic masking and can potentially disrupt the cross-linking density of pectin-based matrices.

🔬 Thin-Film Oral Strips

The typical therapeutic dosage of Arctiin exceeds the standard 30mg payload capacity of thin-film polymers, necessitating high-potency extracts to maintain strip structural integrity.

For Brand Founders

Formulate with Arctium lappa (Arctiin)

Ready to launch a product featuring Arctium lappa (Arctiin)? Skip months of expensive wet-lab iterations. Generate a manufacturer-ready formulation in hours, instantly screened for physical incompatibilities and global regulatory compliance.

Build Science-Backed Formulation

Efficacy Evidence

Maximize Arctium lappa (Arctiin) Bioavailability

Need absolute proof that your Arctium lappa (Arctiin) extract actually absorbs? Stop blindly combining generic powders. Run a physics-based PBPK simulation to mathematically engineer peak clinical efficacy and targeted plasma concentrations.

Simulate Bioavailability

For R&D Labs & CDMOs

Arctium lappa (Arctiin) Degradation Testing

Is your Arctium lappa (Arctiin) payload degrading in the capsule before the expiration date? Stop waiting for costly bench testing. Run an accelerated digital twin to precisely model oxidation pathways and pH shifts before finalizing a manufacturing run.

Model Active Degradation