Ashwagandha (Withaferin A)

Accelerate your CDMO or DTC pipeline. Map the exact physiochemical constraints, bioavailability synergies, and optimal delivery mechanisms for Ashwagandha (Withaferin A).

Ashwagandha functions as a potent adaptogen by modulating the hypothalamic-pituitary-adrenal (HPA) axis and exerting GABAergic mimetic activity to reduce serum cortisol and systemic oxidative stress.

Verified Molecular Profiling (NIH PubChem)

PubChem CID

265237

Molecular Weight

470.6 g/mol

XLogP3 (Lipophilicity)

3.8

IUPAC Name

(1S,2R,6S,7R,9R,11S,12S,15R,16S)-6-hydroxy-15-[(1S)-1-[(2R)-5-(hydroxymethyl)-4-methyl-6-oxo-2,3-dihydropyran-2-yl]ethyl]-2,16-dimethyl-8-oxapentacyclo[9.7.0.02,7.07,9.012,16]octadec-4-en-3-one

Pharmacokinetic Synergies & Enhancers

Proven Synergy Pairings

L-Theanine for synergistic anxiolysis via NMDA receptor modulation
Bacopa monnieri for enhanced cognitive performance and neuroprotection

Biological Formulation Enhancers

Piperine for inhibition of glucuronidation to increase systemic exposure
Lecithin for liposomal encapsulation to improve intestinal permeability of steroidal lactones

Delivery System Constraints & Modeling

Every active compound behaves uniquely based on the physical matrix it is suspended in. Below are the known physical chemistry challenges for Ashwagandha (Withaferin A) across standard consumer modalities.

💊 Standard Capsules

The high hygroscopicity of concentrated withanolide extracts requires moisture-resistant HPMC shells to prevent clumping and degradation.

🍬 Gummy & Pectin Formats

The inherent bitterness and earthy organoleptic profile of Ashwagandha require high-intensity sweeteners and acidulants to mask the flavor in pectin-based matrices.

🔬 Thin-Film Oral Strips

The high therapeutic dose requirement (typically 300-600mg) exceeds the standard 50mg payload capacity of polymer-based thin-film oral strips.

For Brand Founders

Formulate with Ashwagandha (Withaferin A)

Ready to launch a product featuring Ashwagandha (Withaferin A)? Skip months of expensive wet-lab iterations. Generate a manufacturer-ready formulation in hours, instantly screened for physical incompatibilities and global regulatory compliance.

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Efficacy Evidence

Maximize Ashwagandha (Withaferin A) Bioavailability

Need absolute proof that your Ashwagandha (Withaferin A) extract actually absorbs? Stop blindly combining generic powders. Run a physics-based PBPK simulation to mathematically engineer peak clinical efficacy and targeted plasma concentrations.

Simulate Bioavailability

For R&D Labs & CDMOs

Ashwagandha (Withaferin A) Degradation Testing

Is your Ashwagandha (Withaferin A) payload degrading in the capsule before the expiration date? Stop waiting for costly bench testing. Run an accelerated digital twin to precisely model oxidation pathways and pH shifts before finalizing a manufacturing run.

Model Active Degradation