Astragalin (Kaempferol-3-O-glucoside)

Accelerate your CDMO or DTC pipeline. Map the exact physiochemical constraints, bioavailability synergies, and optimal delivery mechanisms for Astragalin (Kaempferol-3-O-glucoside).

A flavonoid glycoside primarily recognized for its potent anti-inflammatory, antioxidant, and anti-allergic properties mediated through the inhibition of NF-κB and MAPK signaling pathways.

Verified Molecular Profiling (NIH PubChem)

PubChem CID

5282102

Molecular Weight

448.4 g/mol

XLogP3 (Lipophilicity)

0.7

IUPAC Name

5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one

Pharmacokinetic Synergies & Enhancers

Proven Synergy Pairings

Quercetin for synergistic inhibition of histamine release in mast cells
Luteolin for enhanced suppression of pro-inflammatory cytokines

Biological Formulation Enhancers

Piperine for inhibition of glucuronidation to increase systemic bioavailability
Quercetin for competitive inhibition of intestinal efflux transporters like P-glycoprotein

Delivery System Constraints & Modeling

Every active compound behaves uniquely based on the physical matrix it is suspended in. Below are the known physical chemistry challenges for Astragalin (Kaempferol-3-O-glucoside) across standard consumer modalities.

💊 Standard Capsules

Astragalin's hygroscopic nature requires moisture-controlled environments to prevent clumping and ensure consistent dissolution rates in hard-shell capsules.

🍬 Gummy & Pectin Formats

The molecule's sensitivity to high thermal processing temperatures during pectin gelation can lead to oxidative degradation and loss of potency.

🔬 Thin-Film Oral Strips

Low aqueous solubility and a relatively high effective dose create significant payload challenges for the limited polymer matrix volume of thin-film strips.

For Brand Founders

Formulate with Astragalin (Kaempferol-3-O-glucoside)

Ready to launch a product featuring Astragalin (Kaempferol-3-O-glucoside)? Skip months of expensive wet-lab iterations. Generate a manufacturer-ready formulation in hours, instantly screened for physical incompatibilities and global regulatory compliance.

Build Science-Backed Formulation

Efficacy Evidence

Maximize Astragalin (Kaempferol-3-O-glucoside) Bioavailability

Need absolute proof that your Astragalin (Kaempferol-3-O-glucoside) extract actually absorbs? Stop blindly combining generic powders. Run a physics-based PBPK simulation to mathematically engineer peak clinical efficacy and targeted plasma concentrations.

Simulate Bioavailability

For R&D Labs & CDMOs

Astragalin (Kaempferol-3-O-glucoside) Degradation Testing

Is your Astragalin (Kaempferol-3-O-glucoside) payload degrading in the capsule before the expiration date? Stop waiting for costly bench testing. Run an accelerated digital twin to precisely model oxidation pathways and pH shifts before finalizing a manufacturing run.

Model Active Degradation