Scutellaria baicalensis (Baicalin)

Accelerate your CDMO or DTC pipeline. Map the exact physiochemical constraints, bioavailability synergies, and optimal delivery mechanisms for Scutellaria baicalensis (Baicalin).

Baicalin is a flavone glycoside that modulates GABA-A receptors and inhibits pro-inflammatory cytokines via the NF-κB pathway, offering potent neuroprotective and anti-inflammatory therapeutic potential.

Verified Molecular Profiling (NIH PubChem)

PubChem CID

5281037

Molecular Weight

424.5 g/mol

XLogP3 (Lipophilicity)

4.5

IUPAC Name

4-[[2-butyl-5-[(E)-2-carboxy-3-thiophen-2-ylprop-1-enyl]imidazol-1-yl]methyl]benzoic acid

Pharmacokinetic Synergies & Enhancers

Proven Synergy Pairings

L-Theanine for synergistic GABAergic modulation and anxiolytic effects
Curcumin for enhanced suppression of inflammatory markers like IL-6 and TNF-alpha

Biological Formulation Enhancers

Piperine for inhibition of glucuronidation to increase systemic bioavailability
Quercetin for competitive inhibition of efflux transporters like P-glycoprotein

Delivery System Constraints & Modeling

Every active compound behaves uniquely based on the physical matrix it is suspended in. Below are the known physical chemistry challenges for Scutellaria baicalensis (Baicalin) across standard consumer modalities.

💊 Standard Capsules

Baicalin's low aqueous solubility and high crystalline density require micronization or the addition of surfactants to ensure consistent dissolution rates in gastric fluid.

🍬 Gummy & Pectin Formats

The inherent bitterness and astringency of baicalin necessitate complex masking agents and may interfere with pectin gelation due to its polyphenolic structure.

🔬 Thin-Film Oral Strips

The high therapeutic dose required for baicalin often exceeds the 20-30mg payload capacity of standard thin-film matrices, leading to structural brittleness.

For Brand Founders

Formulate with Scutellaria baicalensis (Baicalin)

Ready to launch a product featuring Scutellaria baicalensis (Baicalin)? Skip months of expensive wet-lab iterations. Generate a manufacturer-ready formulation in hours, instantly screened for physical incompatibilities and global regulatory compliance.

Build Science-Backed Formulation

Efficacy Evidence

Maximize Scutellaria baicalensis (Baicalin) Bioavailability

Need absolute proof that your Scutellaria baicalensis (Baicalin) extract actually absorbs? Stop blindly combining generic powders. Run a physics-based PBPK simulation to mathematically engineer peak clinical efficacy and targeted plasma concentrations.

Simulate Bioavailability

For R&D Labs & CDMOs

Scutellaria baicalensis (Baicalin) Degradation Testing

Is your Scutellaria baicalensis (Baicalin) payload degrading in the capsule before the expiration date? Stop waiting for costly bench testing. Run an accelerated digital twin to precisely model oxidation pathways and pH shifts before finalizing a manufacturing run.

Model Active Degradation