Beta-Cyclodextrin

Accelerate your CDMO or DTC pipeline. Map the exact physiochemical constraints, bioavailability synergies, and optimal delivery mechanisms for Beta-Cyclodextrin.

A cyclic oligosaccharide composed of seven glucopyranose units that functions as a molecular chelator to enhance the solubility, stability, and bioavailability of lipophilic guest molecules through inclusion complex formation.

Verified Molecular Profiling (NIH PubChem)

PubChem CID

444041

Molecular Weight

1135.0 g/mol

XLogP3 (Lipophilicity)

-15

IUPAC Name

(1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23R,25R,26S,28R,30R,31S,33R,35R,36R,37R,38R,39R,40R,41R,42R,43R,44R,45R,46R,47R,48R,49R)-5,10,15,20,25,30,35-heptakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane-36,37,38,39,40,41,42,43,44,45,46,47,48,49-tetradecol

Pharmacokinetic Synergies & Enhancers

Proven Synergy Pairings

Curcumin for [enhanced aqueous solubility and metabolic stability]
Coenzyme Q10 for [improved dissolution rates and intestinal absorption]

Biological Formulation Enhancers

Hydroxypropyl Methylcellulose (HPMC) for [stabilizing supersaturated states and preventing precipitation]
Polyvinylpyrrolidone (PVP) for [increasing the complexation efficiency and guest loading capacity]

Delivery System Constraints & Modeling

Every active compound behaves uniquely based on the physical matrix it is suspended in. Below are the known physical chemistry challenges for Beta-Cyclodextrin across standard consumer modalities.

💊 Standard Capsules

The high bulk density and required molar ratio for guest inclusion often necessitate large capsule sizes, limiting the total active payload per dose.

🍬 Gummy & Pectin Formats

High concentrations of beta-cyclodextrin can alter the pectin gel matrix texture, potentially leading to a granular mouthfeel or compromised structural elasticity.

🔬 Thin-Film Oral Strips

The significant molecular weight and volume of the inclusion complex severely restrict the maximum achievable dose within the thin-film polymer matrix.

For Brand Founders

Formulate with Beta-Cyclodextrin

Ready to launch a product featuring Beta-Cyclodextrin? Skip months of expensive wet-lab iterations. Generate a manufacturer-ready formulation in hours, instantly screened for physical incompatibilities and global regulatory compliance.

Build Science-Backed Formulation

Efficacy Evidence

Maximize Beta-Cyclodextrin Bioavailability

Need absolute proof that your Beta-Cyclodextrin extract actually absorbs? Stop blindly combining generic powders. Run a physics-based PBPK simulation to mathematically engineer peak clinical efficacy and targeted plasma concentrations.

Simulate Bioavailability

For R&D Labs & CDMOs

Beta-Cyclodextrin Degradation Testing

Is your Beta-Cyclodextrin payload degrading in the capsule before the expiration date? Stop waiting for costly bench testing. Run an accelerated digital twin to precisely model oxidation pathways and pH shifts before finalizing a manufacturing run.

Model Active Degradation