Calcium L-5-Methyltetrahydrofolate

Accelerate your CDMO or DTC pipeline. Map the exact physiochemical constraints, bioavailability synergies, and optimal delivery mechanisms for Calcium L-5-Methyltetrahydrofolate.

As the primary biologically active diastereoisomer of folate, this compound bypasses the MTHFR rate-limiting enzymatic conversion to directly provide methyl groups for the conversion of homocysteine to methionine and support nucleic acid synthesis.

Verified Molecular Profiling (NIH PubChem)

PubChem CID

23666113

Molecular Weight

810.1 g/mol

XLogP3 (Lipophilicity)

N/A

IUPAC Name

sodium 2-[1,3-bis[[(E)-octadec-9-enoyl]oxy]propan-2-yloxycarbonylamino]ethyl sulfate

Pharmacokinetic Synergies & Enhancers

Proven Synergy Pairings

Methylcobalamin for synergistic homocysteine remethylation via the methionine synthase pathway
Pyridoxal-5-Phosphate for supporting the transsulfuration pathway and overall B-vitamin homeostasis

Biological Formulation Enhancers

Ascorbic Acid for preventing oxidative degradation of the tetrahydrofolate ring structure during storage and digestion
Riboflavin for optimizing the endogenous recycling of folate species within the one-carbon cycle

Delivery System Constraints & Modeling

Every active compound behaves uniquely based on the physical matrix it is suspended in. Below are the known physical chemistry challenges for Calcium L-5-Methyltetrahydrofolate across standard consumer modalities.

💊 Standard Capsules

Requires low-moisture excipients and airtight packaging to mitigate the high hygroscopicity and oxidative sensitivity of the folate salt.

🍬 Gummy & Pectin Formats

Thermal processing and potential pH fluctuations in gummy matrices can lead to significant potency loss, requiring precise temperature control and antioxidant inclusion.

🔬 Thin-Film Oral Strips

While the low dosage is suitable for thin-film matrices, the molecule's sensitivity to light and moisture necessitates specialized barrier packaging to maintain stability.

For Brand Founders

Formulate with Calcium L-5-Methyltetrahydrofolate

Ready to launch a product featuring Calcium L-5-Methyltetrahydrofolate? Skip months of expensive wet-lab iterations. Generate a manufacturer-ready formulation in hours, instantly screened for physical incompatibilities and global regulatory compliance.

Build Science-Backed Formulation

Efficacy Evidence

Maximize Calcium L-5-Methyltetrahydrofolate Bioavailability

Need absolute proof that your Calcium L-5-Methyltetrahydrofolate extract actually absorbs? Stop blindly combining generic powders. Run a physics-based PBPK simulation to mathematically engineer peak clinical efficacy and targeted plasma concentrations.

Simulate Bioavailability

For R&D Labs & CDMOs

Calcium L-5-Methyltetrahydrofolate Degradation Testing

Is your Calcium L-5-Methyltetrahydrofolate payload degrading in the capsule before the expiration date? Stop waiting for costly bench testing. Run an accelerated digital twin to precisely model oxidation pathways and pH shifts before finalizing a manufacturing run.

Model Active Degradation