Cat's Claw Extract (Mitraphylline)

Accelerate your CDMO or DTC pipeline. Map the exact physiochemical constraints, bioavailability synergies, and optimal delivery mechanisms for Cat's Claw Extract (Mitraphylline).

Cat's Claw extract functions as a potent immunomodulator and anti-inflammatory agent by inhibiting NF-κB activation and modulating cytokine production through its pentacyclic oxindole alkaloids.

Verified Molecular Profiling (NIH PubChem)

PubChem CID

441972

Molecular Weight

424.4 g/mol

XLogP3 (Lipophilicity)

1.9

IUPAC Name

(14S,18S,19S,20R)-5,18-dihydroxy-15-methoxycarbonyl-20-methyl-17-oxa-1,11-diazapentacyclo[10.8.1.02,7.08,21.014,19]henicosa-2(7),3,5,8,10,12(21),15-heptaene-10-carboxylic acid

Pharmacokinetic Synergies & Enhancers

Proven Synergy Pairings

Curcumin for synergistic inhibition of pro-inflammatory prostaglandins and leukotrienes
Glucosamine for enhanced chondroprotective effects in osteoarthritic applications

Biological Formulation Enhancers

Piperine for increasing the systemic bioavailability of the alkaloid fraction via CYP3A4 inhibition
Quercetin for stabilizing the alkaloid profile and providing complementary antioxidant support

Delivery System Constraints & Modeling

Every active compound behaves uniquely based on the physical matrix it is suspended in. Below are the known physical chemistry challenges for Cat's Claw Extract (Mitraphylline) across standard consumer modalities.

💊 Standard Capsules

The hygroscopic nature of the concentrated extract requires moisture-resistant HPMC capsules to prevent clumping and maintain alkaloid stability.

🍬 Gummy & Pectin Formats

The inherent bitterness of oxindole alkaloids necessitates high-intensity sweeteners and acidulants to mask the astringent profile within a pectin matrix.

🔬 Thin-Film Oral Strips

The high therapeutic dosage required for the 3% extract exceeds the typical 50mg payload capacity of thin-film polymers, limiting its use to low-dose maintenance applications.

For Brand Founders

Formulate with Cat's Claw Extract (Mitraphylline)

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Efficacy Evidence

Maximize Cat's Claw Extract (Mitraphylline) Bioavailability

Need absolute proof that your Cat's Claw Extract (Mitraphylline) extract actually absorbs? Stop blindly combining generic powders. Run a physics-based PBPK simulation to mathematically engineer peak clinical efficacy and targeted plasma concentrations.

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For R&D Labs & CDMOs

Cat's Claw Extract (Mitraphylline) Degradation Testing

Is your Cat's Claw Extract (Mitraphylline) payload degrading in the capsule before the expiration date? Stop waiting for costly bench testing. Run an accelerated digital twin to precisely model oxidation pathways and pH shifts before finalizing a manufacturing run.

Model Active Degradation