Chitosan (Poly-D-glucosamine)

Accelerate your CDMO or DTC pipeline. Map the exact physiochemical constraints, bioavailability synergies, and optimal delivery mechanisms for Chitosan (Poly-D-glucosamine).

A linear polysaccharide derived from chitin that functions as a polycationic lipid-binding fiber and mucoadhesive agent, primarily utilized for weight management and controlled-release drug delivery.

Verified Molecular Profiling (NIH PubChem)

PubChem CID

71853

Molecular Weight

1526.5 g/mol

XLogP3 (Lipophilicity)

-21.4

IUPAC Name

methyl N-[(2S,3R,4R,5S,6R)-5-[(2S,3R,4R,5S,6R)-3-amino-5-[(2S,3R,4R,5S,6R)-3-amino-5-[(2S,3R,4R,5S,6R)-3-amino-5-[(2S,3R,4R,5S,6R)-3-amino-5-[(2S,3R,4R,5S,6R)-3-amino-5-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-[(2R,3S,4R,5R,6S)-5-amino-6-[(2R,3S,4R,5R,6R)-5-amino-4,6-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-4-hydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxan-3-yl]carbamate

Pharmacokinetic Synergies & Enhancers

Proven Synergy Pairings

Vitamin C for [Enhancing lipid-binding capacity through gastric pH modulation]
Psyllium Husk for [Additive fecal fat excretion and synergistic satiety enhancement]

Biological Formulation Enhancers

Citric Acid for [Improving polymer solubility and cationic charge density in the stomach]
Lactic Acid for [Enhancing hydration kinetics and mucoadhesive strength]

Delivery System Constraints & Modeling

Every active compound behaves uniquely based on the physical matrix it is suspended in. Below are the known physical chemistry challenges for Chitosan (Poly-D-glucosamine) across standard consumer modalities.

💊 Standard Capsules

High bulk density and hygroscopic nature require moisture-resistant shells to prevent clumping and ensure consistent disintegration profiles.

🍬 Gummy & Pectin Formats

The high molecular weight and viscosity of chitosan can interfere with pectin gelation, leading to a gritty texture and compromised structural integrity.

🔬 Thin-Film Oral Strips

Significant payload requirements for effective lipid binding exceed the structural capacity of thin-film matrices, which are typically limited to 50mg of active material.

For Brand Founders

Formulate with Chitosan (Poly-D-glucosamine)

Ready to launch a product featuring Chitosan (Poly-D-glucosamine)? Skip months of expensive wet-lab iterations. Generate a manufacturer-ready formulation in hours, instantly screened for physical incompatibilities and global regulatory compliance.

Build Science-Backed Formulation

Efficacy Evidence

Maximize Chitosan (Poly-D-glucosamine) Bioavailability

Need absolute proof that your Chitosan (Poly-D-glucosamine) extract actually absorbs? Stop blindly combining generic powders. Run a physics-based PBPK simulation to mathematically engineer peak clinical efficacy and targeted plasma concentrations.

Simulate Bioavailability

For R&D Labs & CDMOs

Chitosan (Poly-D-glucosamine) Degradation Testing

Is your Chitosan (Poly-D-glucosamine) payload degrading in the capsule before the expiration date? Stop waiting for costly bench testing. Run an accelerated digital twin to precisely model oxidation pathways and pH shifts before finalizing a manufacturing run.

Model Active Degradation