Home The Active Ingredient Matrix Cichorium intybus (Cichoric acid)

Formulation Intelligence

Cichorium intybus (Cichoric acid)

Accelerate your CDMO or DTC pipeline. Map the exact physiochemical constraints, bioavailability synergies, and optimal delivery mechanisms for Cichorium intybus (Cichoric acid).

Cichoric acid is a potent polyphenolic compound that functions as a glucose-sensitizing agent and HIV-1 integrase inhibitor, primarily modulating metabolic pathways through AMPK activation and reducing oxidative stress.

Verified Molecular Profiling (NIH PubChem)

PubChem CID

5281764

Molecular Weight

474.4 g/mol

XLogP3 (Lipophilicity)

2

IUPAC Name

(2R,3R)-2,3-bis[[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]butanedioic acid

Pharmacokinetic Synergies & Enhancers

Proven Synergy Pairings

  • Chlorogenic acid for additive antioxidant capacity and glycemic control
  • Echinacea purpurea extract for synergistic immunomodulatory and antiviral activity

Biological Formulation Enhancers

  • Piperine for inhibition of hepatic glucuronidation to increase systemic polyphenol residence time
  • Phosphatidylcholine for the formation of phytosome complexes to enhance intestinal permeability

Delivery System Constraints & Modeling

Every active compound behaves uniquely based on the physical matrix it is suspended in. Below are the known physical chemistry challenges for Cichorium intybus (Cichoric acid) across standard consumer modalities.

💊 Standard Capsules

The hygroscopic nature of concentrated chicory extracts necessitates the use of HPMC shells and moisture-barrier excipients to prevent the hydrolytic degradation of cichoric acid.

🍬 Gummy & Pectin Formats

Cichoric acid is susceptible to thermal degradation and pH-induced hydrolysis, requiring low-temperature processing and precise buffering to maintain stability within a pectin matrix.

🔬 Thin-Film Oral Strips

The high therapeutic dosage required for metabolic efficacy typically exceeds the 50mg payload capacity of standard thin-film polymer matrices, limiting its application in this format.

For Brand Founders

Formulate with Cichorium intybus (Cichoric acid)

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Build Science-Backed Formulation

Efficacy Evidence

Maximize Cichorium intybus (Cichoric acid) Bioavailability

Need absolute proof that your Cichorium intybus (Cichoric acid) extract actually absorbs? Stop blindly combining generic powders. Run a physics-based PBPK simulation to mathematically engineer peak clinical efficacy and targeted plasma concentrations.

Simulate Bioavailability

For R&D Labs & CDMOs

Cichorium intybus (Cichoric acid) Degradation Testing

Is your Cichorium intybus (Cichoric acid) payload degrading in the capsule before the expiration date? Stop waiting for costly bench testing. Run an accelerated digital twin to precisely model oxidation pathways and pH shifts before finalizing a manufacturing run.

Model Active Degradation