Saffron (Crocin)

Accelerate your CDMO or DTC pipeline. Map the exact physiochemical constraints, bioavailability synergies, and optimal delivery mechanisms for Saffron (Crocin).

A water-soluble carotenoid glycoside that exerts potent neuroprotective, antidepressant, and antioxidant effects by modulating NMDA receptor signaling and inhibiting the reuptake of monoamine neurotransmitters.

Verified Molecular Profiling (NIH PubChem)

PubChem CID

5281233

Molecular Weight

977.0 g/mol

XLogP3 (Lipophilicity)

-2.5

IUPAC Name

bis[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl] (2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethylhexadeca-2,4,6,8,10,12,14-heptaenedioate

Pharmacokinetic Synergies & Enhancers

Proven Synergy Pairings

Safranal for [Complementary modulation of GABA-A receptors and serotonin reuptake inhibition]
Curcumin for [Additive anti-inflammatory effects via NF-kB pathway inhibition]

Biological Formulation Enhancers

Piperine for [Inhibition of glucuronidation to increase systemic bioavailability]
Quercetin for [Synergistic inhibition of oxidative stress and potential P-glycoprotein modulation]

Delivery System Constraints & Modeling

Every active compound behaves uniquely based on the physical matrix it is suspended in. Below are the known physical chemistry challenges for Saffron (Crocin) across standard consumer modalities.

💊 Standard Capsules

Crocin is highly hygroscopic and sensitive to light-induced degradation, requiring opaque capsules and desiccants to maintain chemical stability.

🍬 Gummy & Pectin Formats

The intense carotenoid pigmentation of crocin can cause significant staining of manufacturing equipment and may lead to color instability in pectin-based matrices over time.

🔬 Thin-Film Oral Strips

The high molecular weight and dosage requirements of crocin limit its inclusion in thin-film strips, often necessitating taste-masking for its distinct bitter profile.

For Brand Founders

Formulate with Saffron (Crocin)

Ready to launch a product featuring Saffron (Crocin)? Skip months of expensive wet-lab iterations. Generate a manufacturer-ready formulation in hours, instantly screened for physical incompatibilities and global regulatory compliance.

Build Science-Backed Formulation

Efficacy Evidence

Maximize Saffron (Crocin) Bioavailability

Need absolute proof that your Saffron (Crocin) extract actually absorbs? Stop blindly combining generic powders. Run a physics-based PBPK simulation to mathematically engineer peak clinical efficacy and targeted plasma concentrations.

Simulate Bioavailability

For R&D Labs & CDMOs

Saffron (Crocin) Degradation Testing

Is your Saffron (Crocin) payload degrading in the capsule before the expiration date? Stop waiting for costly bench testing. Run an accelerated digital twin to precisely model oxidation pathways and pH shifts before finalizing a manufacturing run.

Model Active Degradation