Epimedium brevicornum (Icariin)

Accelerate your CDMO or DTC pipeline. Map the exact physiochemical constraints, bioavailability synergies, and optimal delivery mechanisms for Epimedium brevicornum (Icariin).

Icariin functions as a prenylated flavonol glycoside that exerts phosphodiesterase type 5 (PDE5) inhibition and promotes osteogenic differentiation through the activation of the Wnt/beta-catenin signaling pathway.

Verified Molecular Profiling (NIH PubChem)

PubChem CID

5318997

Molecular Weight

676.7 g/mol

XLogP3 (Lipophilicity)

1.7

IUPAC Name

5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxychromen-4-one

Pharmacokinetic Synergies & Enhancers

Proven Synergy Pairings

L-Citrulline for synergistic elevation of cyclic guanosine monophosphate (cGMP) via the nitric oxide-dependent pathway
Maca Root for complementary modulation of the hypothalamic-pituitary-gonadal axis

Biological Formulation Enhancers

Piperine for inhibition of P-glycoprotein and CYP3A4-mediated first-pass metabolism
Quercetin for competitive inhibition of UGT-mediated glucuronidation to increase plasma concentration

Delivery System Constraints & Modeling

Every active compound behaves uniquely based on the physical matrix it is suspended in. Below are the known physical chemistry challenges for Epimedium brevicornum (Icariin) across standard consumer modalities.

💊 Standard Capsules

High-purity icariin extracts are notably hygroscopic, requiring low-moisture HPMC shells and desiccants to prevent powder caking and oxidation.

🍬 Gummy & Pectin Formats

The intense bitterness and astringency of prenylated flavonoids require advanced organoleptic masking and can destabilize pectin-based matrices at high inclusion rates.

🔬 Thin-Film Oral Strips

The typical therapeutic dosage of Epimedium extract significantly exceeds the 50mg payload limit of standard thin-film polymers, necessitating high-potency standardized isolates.

For Brand Founders

Formulate with Epimedium brevicornum (Icariin)

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Efficacy Evidence

Maximize Epimedium brevicornum (Icariin) Bioavailability

Need absolute proof that your Epimedium brevicornum (Icariin) extract actually absorbs? Stop blindly combining generic powders. Run a physics-based PBPK simulation to mathematically engineer peak clinical efficacy and targeted plasma concentrations.

Simulate Bioavailability

For R&D Labs & CDMOs

Epimedium brevicornum (Icariin) Degradation Testing

Is your Epimedium brevicornum (Icariin) payload degrading in the capsule before the expiration date? Stop waiting for costly bench testing. Run an accelerated digital twin to precisely model oxidation pathways and pH shifts before finalizing a manufacturing run.

Model Active Degradation