Glycyrrhiza glabra (Glycyrrhizic Acid)

Accelerate your CDMO or DTC pipeline. Map the exact physiochemical constraints, bioavailability synergies, and optimal delivery mechanisms for Glycyrrhiza glabra (Glycyrrhizic Acid).

Glycyrrhiza glabra functions primarily as a mineralocorticoid-mimetic and anti-inflammatory agent by inhibiting 11β-hydroxysteroid dehydrogenase, thereby modulating cortisol metabolism and providing cytoprotective effects on gastric mucosa.

Verified Molecular Profiling (NIH PubChem)

PubChem CID

14982

Molecular Weight

822.9 g/mol

XLogP3 (Lipophilicity)

3.7

IUPAC Name

(2S,3S,4S,5R,6R)-6-[(2S,3R,4S,5S,6S)-2-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-6-carboxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid

Pharmacokinetic Synergies & Enhancers

Proven Synergy Pairings

Curcumin for enhanced anti-inflammatory modulation of the NF-κB pathway
Matricaria chamomilla for synergistic spasmolytic effects in gastrointestinal applications

Biological Formulation Enhancers

Phosphatidylcholine for improved lipophilic transport and intestinal permeability via phytosome formation
Quercetin for potential inhibition of metabolic degradation and enhanced antioxidant synergy

Delivery System Constraints & Modeling

Every active compound behaves uniquely based on the physical matrix it is suspended in. Below are the known physical chemistry challenges for Glycyrrhiza glabra (Glycyrrhizic Acid) across standard consumer modalities.

💊 Standard Capsules

The hygroscopic nature of concentrated licorice extracts requires moisture-barrier packaging to prevent clumping and degradation of the glycyrrhizic acid content.

🍬 Gummy & Pectin Formats

High concentrations of glycyrrhizic acid can impart an intense, lingering sweetness and distinct anise-like flavor profile that is difficult to mask in pectin-based matrices.

🔬 Thin-Film Oral Strips

The high effective dose required for therapeutic glycyrrhizin levels often exceeds the 20-30mg payload capacity of standard thin-film polymer matrices.

For Brand Founders

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Efficacy Evidence

Maximize Glycyrrhiza glabra (Glycyrrhizic Acid) Bioavailability

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For R&D Labs & CDMOs

Glycyrrhiza glabra (Glycyrrhizic Acid) Degradation Testing

Is your Glycyrrhiza glabra (Glycyrrhizic Acid) payload degrading in the capsule before the expiration date? Stop waiting for costly bench testing. Run an accelerated digital twin to precisely model oxidation pathways and pH shifts before finalizing a manufacturing run.

Model Active Degradation