Glycyrrhiza uralensis (Glycyrrhizic acid)

Accelerate your CDMO or DTC pipeline. Map the exact physiochemical constraints, bioavailability synergies, and optimal delivery mechanisms for Glycyrrhiza uralensis (Glycyrrhizic acid).

Glycyrrhizic acid functions as a potent triterpenoid saponin that modulates the 11β-hydroxysteroid dehydrogenase enzyme system to prolong cortisol half-life and exerts significant anti-inflammatory effects through the inhibition of HMGB1 signaling pathways.

Verified Molecular Profiling (NIH PubChem)

PubChem CID

14982

Molecular Weight

822.9 g/mol

XLogP3 (Lipophilicity)

3.7

IUPAC Name

(2S,3S,4S,5R,6R)-6-[(2S,3R,4S,5S,6S)-2-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-6-carboxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid

Pharmacokinetic Synergies & Enhancers

Proven Synergy Pairings

Quercetin for synergistic inhibition of viral entry and replication
Paeoniflorin for enhanced antispasmodic and anti-inflammatory activity in gastrointestinal applications

Biological Formulation Enhancers

Phosphatidylcholine for improved lipophilic micellar absorption of the saponin structure
Cyclodextrins for increasing the aqueous solubility and masking the intense sweetness of the glycoside

Delivery System Constraints & Modeling

Every active compound behaves uniquely based on the physical matrix it is suspended in. Below are the known physical chemistry challenges for Glycyrrhiza uralensis (Glycyrrhizic acid) across standard consumer modalities.

💊 Standard Capsules

The hygroscopic nature of concentrated glycyrrhizic acid extracts requires moisture-resistant HPMC shells to prevent clumping and degradation over time.

🍬 Gummy & Pectin Formats

The intense, lingering sweetness and surfactant properties of glycyrrhizic acid can interfere with pectin gelation kinetics and significantly alter the final flavor profile.

🔬 Thin-Film Oral Strips

High dosage requirements for therapeutic efficacy often exceed the 20-30mg payload capacity of standard thin-film polymer matrices.

For Brand Founders

Formulate with Glycyrrhiza uralensis (Glycyrrhizic acid)

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Efficacy Evidence

Maximize Glycyrrhiza uralensis (Glycyrrhizic acid) Bioavailability

Need absolute proof that your Glycyrrhiza uralensis (Glycyrrhizic acid) extract actually absorbs? Stop blindly combining generic powders. Run a physics-based PBPK simulation to mathematically engineer peak clinical efficacy and targeted plasma concentrations.

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For R&D Labs & CDMOs

Glycyrrhiza uralensis (Glycyrrhizic acid) Degradation Testing

Is your Glycyrrhiza uralensis (Glycyrrhizic acid) payload degrading in the capsule before the expiration date? Stop waiting for costly bench testing. Run an accelerated digital twin to precisely model oxidation pathways and pH shifts before finalizing a manufacturing run.

Model Active Degradation