Devil's Claw (Harpagoside)

Accelerate your CDMO or DTC pipeline. Map the exact physiochemical constraints, bioavailability synergies, and optimal delivery mechanisms for Devil's Claw (Harpagoside).

Harpagoside is a bioactive iridoid glycoside that exerts potent anti-inflammatory and analgesic effects by inhibiting the expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) within the arachidonic acid cascade.

Verified Molecular Profiling (NIH PubChem)

PubChem CID

5281542

Molecular Weight

494.5 g/mol

XLogP3 (Lipophilicity)

-0.6

IUPAC Name

[(1S,4aS,5R,7S,7aS)-4a,5-dihydroxy-7-methyl-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,5,6,7a-tetrahydrocyclopenta[c]pyran-7-yl] (E)-3-phenylprop-2-enoate

Pharmacokinetic Synergies & Enhancers

Proven Synergy Pairings

Glucosamine Sulfate for synergistic joint cartilage matrix support
Curcumin for multi-pathway inhibition of pro-inflammatory cytokines like TNF-alpha

Biological Formulation Enhancers

Piperine for inhibition of hepatic glucuronidation to increase systemic plasma concentrations
Hydroxypropyl-beta-cyclodextrin for enhancing aqueous solubility and intestinal permeability of the glycoside

Delivery System Constraints & Modeling

Every active compound behaves uniquely based on the physical matrix it is suspended in. Below are the known physical chemistry challenges for Devil's Claw (Harpagoside) across standard consumer modalities.

💊 Standard Capsules

The hygroscopic nature of concentrated Harpagoside extracts requires the use of low-moisture HPMC capsules and desiccants to prevent powder caking and degradation.

🍬 Gummy & Pectin Formats

The intense inherent bitterness of iridoid glycosides necessitates advanced organoleptic masking and strict temperature control to prevent hydrolytic cleavage of the glycosidic bond during the pectin boiling phase.

🔬 Thin-Film Oral Strips

The high therapeutic dose required for clinical efficacy typically exceeds the 20-30mg payload capacity of standard thin-film polymer matrices, limiting its application in this format.

For Brand Founders

Formulate with Devil's Claw (Harpagoside)

Ready to launch a product featuring Devil's Claw (Harpagoside)? Skip months of expensive wet-lab iterations. Generate a manufacturer-ready formulation in hours, instantly screened for physical incompatibilities and global regulatory compliance.

Build Science-Backed Formulation

Efficacy Evidence

Maximize Devil's Claw (Harpagoside) Bioavailability

Need absolute proof that your Devil's Claw (Harpagoside) extract actually absorbs? Stop blindly combining generic powders. Run a physics-based PBPK simulation to mathematically engineer peak clinical efficacy and targeted plasma concentrations.

Simulate Bioavailability

For R&D Labs & CDMOs

Devil's Claw (Harpagoside) Degradation Testing

Is your Devil's Claw (Harpagoside) payload degrading in the capsule before the expiration date? Stop waiting for costly bench testing. Run an accelerated digital twin to precisely model oxidation pathways and pH shifts before finalizing a manufacturing run.

Model Active Degradation