Lion's Mane (Hericenone C)

Accelerate your CDMO or DTC pipeline. Map the exact physiochemical constraints, bioavailability synergies, and optimal delivery mechanisms for Lion's Mane (Hericenone C).

Hericenone C is a meroterpenoid derived from Hericium erinaceus that promotes neurogenesis by stimulating the synthesis and secretion of Nerve Growth Factor (NGF) in astrocytes via the activation of the JNK signaling pathway.

Verified Molecular Profiling (NIH PubChem)

PubChem CID

10430371

Molecular Weight

388.5 g/mol

XLogP3 (Lipophilicity)

5.9

IUPAC Name

N-[1-(2,6-dimethylbenzoyl)-2-methylindol-5-yl]cyclohexanecarboxamide

Pharmacokinetic Synergies & Enhancers

Proven Synergy Pairings

Erinacine A for complementary stimulation of NGF in the central nervous system
DHA for providing the structural lipid substrate required for NGF-induced neurite outgrowth

Biological Formulation Enhancers

Lecithin for improving the micellar solubilization of lipophilic meroterpenoids
Piperine for inhibiting glucuronidation and increasing systemic bioavailability

Delivery System Constraints & Modeling

Every active compound behaves uniquely based on the physical matrix it is suspended in. Below are the known physical chemistry challenges for Lion's Mane (Hericenone C) across standard consumer modalities.

💊 Standard Capsules

The hygroscopic nature of concentrated Hericium extracts requires the inclusion of moisture-resistant excipients to prevent oxidative degradation of the hericenone content.

🍬 Gummy & Pectin Formats

The thermal sensitivity of phenolic hericenones necessitates a low-temperature deposition process to avoid structural degradation during the pectin gelation phase.

🔬 Thin-Film Oral Strips

The high molecular weight and low potency per milligram of crude extracts limit the ability to achieve a pharmacologically relevant dose within the restricted polymer matrix of a thin film.

For Brand Founders

Formulate with Lion's Mane (Hericenone C)

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Efficacy Evidence

Maximize Lion's Mane (Hericenone C) Bioavailability

Need absolute proof that your Lion's Mane (Hericenone C) extract actually absorbs? Stop blindly combining generic powders. Run a physics-based PBPK simulation to mathematically engineer peak clinical efficacy and targeted plasma concentrations.

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For R&D Labs & CDMOs

Lion's Mane (Hericenone C) Degradation Testing

Is your Lion's Mane (Hericenone C) payload degrading in the capsule before the expiration date? Stop waiting for costly bench testing. Run an accelerated digital twin to precisely model oxidation pathways and pH shifts before finalizing a manufacturing run.

Model Active Degradation