Horny Goat Weed (Icariin)

Accelerate your CDMO or DTC pipeline. Map the exact physiochemical constraints, bioavailability synergies, and optimal delivery mechanisms for Horny Goat Weed (Icariin).

Horny Goat Weed extract functions primarily as a natural phosphodiesterase type 5 (PDE5) inhibitor and a promoter of nitric oxide synthesis, facilitating improved erectile function and bone density through the modulation of cGMP signaling pathways.

Verified Molecular Profiling (NIH PubChem)

PubChem CID

5318997

Molecular Weight

676.7 g/mol

XLogP3 (Lipophilicity)

1.7

IUPAC Name

5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxychromen-4-one

Pharmacokinetic Synergies & Enhancers

Proven Synergy Pairings

L-Citrulline for synergistic upregulation of the nitric oxide-cGMP pathway
Maca Root for complementary adaptogenic support of libido and endocrine balance

Biological Formulation Enhancers

Piperine for inhibition of P-glycoprotein and CYP3A4 to increase systemic bioavailability
Quercetin for potential inhibition of icariin glucuronidation in the intestinal tract

Delivery System Constraints & Modeling

Every active compound behaves uniquely based on the physical matrix it is suspended in. Below are the known physical chemistry challenges for Horny Goat Weed (Icariin) across standard consumer modalities.

💊 Standard Capsules

The hygroscopic nature of high-purity icariin extracts requires moisture-resistant excipients to prevent clumping and degradation within the capsule shell.

🍬 Gummy & Pectin Formats

The inherent bitterness and astringency of Epimedium flavonoids necessitate complex flavor-masking agents and pH adjustments to maintain pectin integrity.

🔬 Thin-Film Oral Strips

The high therapeutic dose required for efficacy typically exceeds the standard 50mg payload capacity of most thin-film polymer matrices.

For Brand Founders

Formulate with Horny Goat Weed (Icariin)

Ready to launch a product featuring Horny Goat Weed (Icariin)? Skip months of expensive wet-lab iterations. Generate a manufacturer-ready formulation in hours, instantly screened for physical incompatibilities and global regulatory compliance.

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Efficacy Evidence

Maximize Horny Goat Weed (Icariin) Bioavailability

Need absolute proof that your Horny Goat Weed (Icariin) extract actually absorbs? Stop blindly combining generic powders. Run a physics-based PBPK simulation to mathematically engineer peak clinical efficacy and targeted plasma concentrations.

Simulate Bioavailability

For R&D Labs & CDMOs

Horny Goat Weed (Icariin) Degradation Testing

Is your Horny Goat Weed (Icariin) payload degrading in the capsule before the expiration date? Stop waiting for costly bench testing. Run an accelerated digital twin to precisely model oxidation pathways and pH shifts before finalizing a manufacturing run.

Model Active Degradation