Home The Active Ingredient Matrix L-Theanine

Formulation Intelligence

L-Theanine

Accelerate your CDMO or DTC pipeline. Map the exact physiochemical constraints, bioavailability synergies, and optimal delivery mechanisms for L-Theanine.

L-Theanine is a non-proteinogenic amino acid that modulates alpha-wave brain activity and antagonizes glutamate receptors to facilitate anxiolysis and cognitive focus without inducing somnolence.

Verified Molecular Profiling (NIH PubChem)

PubChem CID

439378

Molecular Weight

174.20 g/mol

XLogP3 (Lipophilicity)

-3.6

IUPAC Name

(2S)-2-amino-5-(ethylamino)-5-oxopentanoic acid

Pharmacokinetic Synergies & Enhancers

Proven Synergy Pairings

  • Caffeine for [mitigating jitteriness and enhancing executive function through synergistic alpha-wave modulation]
  • Magnesium Bisglycinate for [potentiating GABAergic signaling and systemic relaxation]

Biological Formulation Enhancers

  • Piperine for [potential enhancement of intestinal transport kinetics]
  • Liposomal Delivery for [improving bypass of first-pass metabolism and increasing neural bioavailability]

Delivery System Constraints & Modeling

Every active compound behaves uniquely based on the physical matrix it is suspended in. Below are the known physical chemistry challenges for L-Theanine across standard consumer modalities.

💊 Standard Capsules

The material is generally stable but requires low-moisture excipients to prevent clumping due to its slight hygroscopicity in high-humidity environments.

🍬 Gummy & Pectin Formats

L-Theanine's umami flavor profile can interfere with fruit-based acidulants, requiring specific flavor masking to prevent a savory aftertaste in the pectin matrix.

🔬 Thin-Film Oral Strips

The standard therapeutic dose of 100-200mg exceeds the typical 20-50mg payload capacity of standard thin-film polymers, necessitating specialized high-loading film technology.

For Brand Founders

Formulate with L-Theanine

Ready to launch a product featuring L-Theanine? Skip months of expensive wet-lab iterations. Generate a manufacturer-ready formulation in hours, instantly screened for physical incompatibilities and global regulatory compliance.

Build Science-Backed Formulation

Efficacy Evidence

Maximize L-Theanine Bioavailability

Need absolute proof that your L-Theanine extract actually absorbs? Stop blindly combining generic powders. Run a physics-based PBPK simulation to mathematically engineer peak clinical efficacy and targeted plasma concentrations.

Simulate Bioavailability

For R&D Labs & CDMOs

L-Theanine Degradation Testing

Is your L-Theanine payload degrading in the capsule before the expiration date? Stop waiting for costly bench testing. Run an accelerated digital twin to precisely model oxidation pathways and pH shifts before finalizing a manufacturing run.

Model Active Degradation