Home The Active Ingredient Matrix Lacto-N-tetraose

Formulation Intelligence

Lacto-N-tetraose

Accelerate your CDMO or DTC pipeline. Map the exact physiochemical constraints, bioavailability synergies, and optimal delivery mechanisms for Lacto-N-tetraose.

A core human milk oligosaccharide (HMO) that acts as a selective prebiotic substrate for Bifidobacterium species, modulating gut microbiota composition and supporting neonatal immune system maturation.

Verified Molecular Profiling (NIH PubChem)

PubChem CID

123831

Molecular Weight

202.25 g/mol

XLogP3 (Lipophilicity)

-3.6

IUPAC Name

(2S)-2-amino-5-[[amino(dimethylamino)methylidene]amino]pentanoic acid

Pharmacokinetic Synergies & Enhancers

Proven Synergy Pairings

  • 2'-Fucosyllactose (2'-FL) for [broad-spectrum prebiotic coverage across different Bifidobacterium strains]
  • Bifidobacterium infantis for [enhanced metabolic utilization and competitive exclusion of pathogens]

Biological Formulation Enhancers

  • Lactoferrin for [synergistic antimicrobial activity and iron sequestration]
  • Galactooligosaccharides (GOS) for [extending the fermentation profile throughout the distal colon]

Delivery System Constraints & Modeling

Every active compound behaves uniquely based on the physical matrix it is suspended in. Below are the known physical chemistry challenges for Lacto-N-tetraose across standard consumer modalities.

💊 Standard Capsules

The hygroscopic nature of the amorphous powder requires moisture-barrier packaging to prevent clumping and maintain long-term stability.

🍬 Gummy & Pectin Formats

High solubility and thermal stability allow for easy integration, though high inclusion levels may disrupt pectin gel networks and increase water activity.

🔬 Thin-Film Oral Strips

Standard therapeutic dosages for HMOs typically exceed the 50mg payload capacity of thin-film polymer matrices, making this format impractical for primary dosing.

For Brand Founders

Formulate with Lacto-N-tetraose

Ready to launch a product featuring Lacto-N-tetraose? Skip months of expensive wet-lab iterations. Generate a manufacturer-ready formulation in hours, instantly screened for physical incompatibilities and global regulatory compliance.

Build Science-Backed Formulation

Efficacy Evidence

Maximize Lacto-N-tetraose Bioavailability

Need absolute proof that your Lacto-N-tetraose extract actually absorbs? Stop blindly combining generic powders. Run a physics-based PBPK simulation to mathematically engineer peak clinical efficacy and targeted plasma concentrations.

Simulate Bioavailability

For R&D Labs & CDMOs

Lacto-N-tetraose Degradation Testing

Is your Lacto-N-tetraose payload degrading in the capsule before the expiration date? Stop waiting for costly bench testing. Run an accelerated digital twin to precisely model oxidation pathways and pH shifts before finalizing a manufacturing run.

Model Active Degradation