Magnolia officinalis (Magnolol)

Accelerate your CDMO or DTC pipeline. Map the exact physiochemical constraints, bioavailability synergies, and optimal delivery mechanisms for Magnolia officinalis (Magnolol).

Magnolol acts as a potent allosteric modulator of GABA-A receptors and a dual PPAR agonist, providing significant anxiolytic, neuroprotective, and anti-inflammatory effects through the inhibition of NF-κB and MAPK signaling pathways.

Verified Molecular Profiling (NIH PubChem)

PubChem CID

72394

Molecular Weight

761.8 g/mol

XLogP3 (Lipophilicity)

-9.9

IUPAC Name

(2R,3S,4S,5S,6R)-2-[(2S,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(2R,3S,4R,5S)-5-[(1R,2R,3S,5R,6S)-3,5-diamino-2-[(2S,3R,5S,6R)-3-amino-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxy-4-hydroxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol

Pharmacokinetic Synergies & Enhancers

Proven Synergy Pairings

Honokiol for synergistic GABAergic modulation and enhanced blood-brain barrier permeability
L-Theanine for complementary glutamate regulation and stress response attenuation

Biological Formulation Enhancers

Piperine for inhibition of hepatic glucuronidation and CYP3A4-mediated metabolism
Medium-Chain Triglycerides (MCTs) for enhanced micellar solubilization of this highly lipophilic polyphenol

Delivery System Constraints & Modeling

Every active compound behaves uniquely based on the physical matrix it is suspended in. Below are the known physical chemistry challenges for Magnolia officinalis (Magnolol) across standard consumer modalities.

💊 Standard Capsules

The high lipophilicity of magnolol necessitates the use of specific flow agents to prevent agglomeration and ensure consistent dissolution profiles in standard dry-fill capsules.

🍬 Gummy & Pectin Formats

Magnolol's poor aqueous solubility and distinct phenolic odor present significant challenges for achieving matrix homogeneity and sensory masking in pectin-based gummy formulations.

🔬 Thin-Film Oral Strips

The typical therapeutic dosage of magnolol exceeds the standard 20-40mg payload capacity of thin-film oral strips, requiring the use of high-potency micronized extracts or complexation with cyclodextrins.

For Brand Founders

Formulate with Magnolia officinalis (Magnolol)

Ready to launch a product featuring Magnolia officinalis (Magnolol)? Skip months of expensive wet-lab iterations. Generate a manufacturer-ready formulation in hours, instantly screened for physical incompatibilities and global regulatory compliance.

Build Science-Backed Formulation

Efficacy Evidence

Maximize Magnolia officinalis (Magnolol) Bioavailability

Need absolute proof that your Magnolia officinalis (Magnolol) extract actually absorbs? Stop blindly combining generic powders. Run a physics-based PBPK simulation to mathematically engineer peak clinical efficacy and targeted plasma concentrations.

Simulate Bioavailability

For R&D Labs & CDMOs

Magnolia officinalis (Magnolol) Degradation Testing

Is your Magnolia officinalis (Magnolol) payload degrading in the capsule before the expiration date? Stop waiting for costly bench testing. Run an accelerated digital twin to precisely model oxidation pathways and pH shifts before finalizing a manufacturing run.

Model Active Degradation