Home The Active Ingredient Matrix Cat's Claw (Mitraphylline)

Formulation Intelligence

Cat's Claw (Mitraphylline)

Accelerate your CDMO or DTC pipeline. Map the exact physiochemical constraints, bioavailability synergies, and optimal delivery mechanisms for Cat's Claw (Mitraphylline).

Mitraphylline is a pentacyclic oxindole alkaloid that modulates the immune response by inhibiting NF-κB signaling and reducing the production of pro-inflammatory cytokines such as TNF-α and IL-6.

Verified Molecular Profiling (NIH PubChem)

PubChem CID

161245

Molecular Weight

224.73 g/mol

XLogP3 (Lipophilicity)

N/A

IUPAC Name

3-(1-phenylpropan-2-ylamino)propanenitrile;hydrochloride

Pharmacokinetic Synergies & Enhancers

Proven Synergy Pairings

  • Isomitraphylline for balanced alkaloid profile and enhanced immunomodulatory efficacy
  • Curcumin for synergistic inhibition of inflammatory pathways and oxidative stress

Biological Formulation Enhancers

  • Piperine for inhibition of hepatic metabolism to increase systemic bioavailability
  • Quercetin for P-glycoprotein inhibition to enhance intestinal absorption and blood-brain barrier permeability

Delivery System Constraints & Modeling

Every active compound behaves uniquely based on the physical matrix it is suspended in. Below are the known physical chemistry challenges for Cat's Claw (Mitraphylline) across standard consumer modalities.

💊 Standard Capsules

The hygroscopic nature of alkaloid extracts requires moisture-resistant excipients to prevent clumping and ensure long-term stability.

🍬 Gummy & Pectin Formats

The inherent bitterness of oxindole alkaloids necessitates advanced flavor-masking agents and careful temperature control to prevent degradation during the pectin setting process.

🔬 Thin-Film Oral Strips

The high therapeutic dose required for mitraphylline often exceeds the 20-30mg payload limit of standard thin-film polymer matrices.

For Brand Founders

Formulate with Cat's Claw (Mitraphylline)

Ready to launch a product featuring Cat's Claw (Mitraphylline)? Skip months of expensive wet-lab iterations. Generate a manufacturer-ready formulation in hours, instantly screened for physical incompatibilities and global regulatory compliance.

Build Science-Backed Formulation

Efficacy Evidence

Maximize Cat's Claw (Mitraphylline) Bioavailability

Need absolute proof that your Cat's Claw (Mitraphylline) extract actually absorbs? Stop blindly combining generic powders. Run a physics-based PBPK simulation to mathematically engineer peak clinical efficacy and targeted plasma concentrations.

Simulate Bioavailability

For R&D Labs & CDMOs

Cat's Claw (Mitraphylline) Degradation Testing

Is your Cat's Claw (Mitraphylline) payload degrading in the capsule before the expiration date? Stop waiting for costly bench testing. Run an accelerated digital twin to precisely model oxidation pathways and pH shifts before finalizing a manufacturing run.

Model Active Degradation