Grapefruit Extract (Naringin)

Accelerate your CDMO or DTC pipeline. Map the exact physiochemical constraints, bioavailability synergies, and optimal delivery mechanisms for Grapefruit Extract (Naringin).

Naringin is a flavanone glycoside that modulates lipid metabolism and exhibits potent antioxidant properties by inhibiting cytochrome P450 enzymes and scavenging reactive oxygen species.

Verified Molecular Profiling (NIH PubChem)

PubChem CID

442428

Molecular Weight

580.5 g/mol

XLogP3 (Lipophilicity)

-0.5

IUPAC Name

(2S)-7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one

Pharmacokinetic Synergies & Enhancers

Proven Synergy Pairings

Caffeine for metabolic rate enhancement and prolonged half-life via CYP1A2 inhibition
Hesperidin for synergistic cardiovascular protection and capillary permeability regulation

Biological Formulation Enhancers

Cyclodextrins for increased aqueous solubility and inclusion complex stability
Piperine for inhibition of intestinal glucuronidation to improve systemic bioavailability

Delivery System Constraints & Modeling

Every active compound behaves uniquely based on the physical matrix it is suspended in. Below are the known physical chemistry challenges for Grapefruit Extract (Naringin) across standard consumer modalities.

💊 Standard Capsules

High hygroscopicity of naringin powder requires moisture-controlled environments to prevent clumping and ensure consistent dissolution rates.

🍬 Gummy & Pectin Formats

The intense, lingering bitterness of naringin necessitates advanced taste-masking agents or encapsulation to prevent sensory rejection in pectin-based matrices.

🔬 Thin-Film Oral Strips

Limited payload capacity of thin films restricts naringin dosage, as high concentrations compromise the structural integrity and flexibility of the polymer matrix.

For Brand Founders

Formulate with Grapefruit Extract (Naringin)

Ready to launch a product featuring Grapefruit Extract (Naringin)? Skip months of expensive wet-lab iterations. Generate a manufacturer-ready formulation in hours, instantly screened for physical incompatibilities and global regulatory compliance.

Build Science-Backed Formulation

Efficacy Evidence

Maximize Grapefruit Extract (Naringin) Bioavailability

Need absolute proof that your Grapefruit Extract (Naringin) extract actually absorbs? Stop blindly combining generic powders. Run a physics-based PBPK simulation to mathematically engineer peak clinical efficacy and targeted plasma concentrations.

Simulate Bioavailability

For R&D Labs & CDMOs

Grapefruit Extract (Naringin) Degradation Testing

Is your Grapefruit Extract (Naringin) payload degrading in the capsule before the expiration date? Stop waiting for costly bench testing. Run an accelerated digital twin to precisely model oxidation pathways and pH shifts before finalizing a manufacturing run.

Model Active Degradation