Ophiopogon japonicus (Ophiopogonin D)

Accelerate your CDMO or DTC pipeline. Map the exact physiochemical constraints, bioavailability synergies, and optimal delivery mechanisms for Ophiopogon japonicus (Ophiopogonin D).

Ophiopogonin D is a steroidal saponin that exerts potent cardioprotective and anti-inflammatory effects by modulating the TGF-β1/Smad signaling pathway and inhibiting CYP2J2-mediated arachidonic acid metabolism.

Verified Molecular Profiling (NIH PubChem)

PubChem CID

11210854

Molecular Weight

368.5 g/mol

XLogP3 (Lipophilicity)

3.2

IUPAC Name

10-methoxy-11-[(3R)-1-methylpyrrolidin-3-yl]indolo[1,2-b][1,2]benzothiazole 5,5-dioxide

Pharmacokinetic Synergies & Enhancers

Proven Synergy Pairings

Panax ginseng for [enhanced myocardial protection via synergistic modulation of PI3K/Akt pathways]
Schisandra chinensis for [improved respiratory mucosal hydration and antitussive efficacy]

Biological Formulation Enhancers

Piperine for [inhibition of P-glycoprotein-mediated efflux to increase saponin bioavailability]
Quercetin for [synergistic inhibition of inflammatory cytokines and improved intestinal permeability]

Delivery System Constraints & Modeling

Every active compound behaves uniquely based on the physical matrix it is suspended in. Below are the known physical chemistry challenges for Ophiopogon japonicus (Ophiopogonin D) across standard consumer modalities.

💊 Standard Capsules

The hygroscopic nature of Ophiopogon extracts requires high-barrier blister packaging to prevent clumping and degradation of the saponin content.

🍬 Gummy & Pectin Formats

High concentrations of steroidal saponins can impart a persistent bitter aftertaste and may interfere with pectin gelation due to their surfactant-like properties.

🔬 Thin-Film Oral Strips

The high molecular weight and required therapeutic dosage of Ophiopogonin D exceed the typical 20-30mg payload capacity of standard thin-film polymer matrices.

For Brand Founders

Formulate with Ophiopogon japonicus (Ophiopogonin D)

Ready to launch a product featuring Ophiopogon japonicus (Ophiopogonin D)? Skip months of expensive wet-lab iterations. Generate a manufacturer-ready formulation in hours, instantly screened for physical incompatibilities and global regulatory compliance.

Build Science-Backed Formulation

Efficacy Evidence

Maximize Ophiopogon japonicus (Ophiopogonin D) Bioavailability

Need absolute proof that your Ophiopogon japonicus (Ophiopogonin D) extract actually absorbs? Stop blindly combining generic powders. Run a physics-based PBPK simulation to mathematically engineer peak clinical efficacy and targeted plasma concentrations.

Simulate Bioavailability

For R&D Labs & CDMOs

Ophiopogon japonicus (Ophiopogonin D) Degradation Testing

Is your Ophiopogon japonicus (Ophiopogonin D) payload degrading in the capsule before the expiration date? Stop waiting for costly bench testing. Run an accelerated digital twin to precisely model oxidation pathways and pH shifts before finalizing a manufacturing run.

Model Active Degradation