Passiflora incarnata (Apigenin)

Accelerate your CDMO or DTC pipeline. Map the exact physiochemical constraints, bioavailability synergies, and optimal delivery mechanisms for Passiflora incarnata (Apigenin).

Passiflora incarnata functions as a positive allosteric modulator of the GABA-A receptor complex and a mild monoamine oxidase inhibitor, primarily utilized for its anxiolytic and sedative properties in managing generalized anxiety disorder and sleep latency.

Verified Molecular Profiling (NIH PubChem)

PubChem CID

5280443

Molecular Weight

270.24 g/mol

XLogP3 (Lipophilicity)

1.7

IUPAC Name

5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one

Pharmacokinetic Synergies & Enhancers

Proven Synergy Pairings

Valeriana officinalis for [potentiating GABAergic signaling via synergistic binding at the benzodiazepine site]
L-Theanine for [modulating alpha-wave activity and attenuating glutamate-induced excitotoxicity]

Biological Formulation Enhancers

Piperine for [inhibiting CYP3A4 and P-glycoprotein to increase the systemic bioavailability of flavone glycosides]
Quercetin for [competitive inhibition of sulfotransferases to prolong the half-life of circulating apigenin]

Delivery System Constraints & Modeling

Every active compound behaves uniquely based on the physical matrix it is suspended in. Below are the known physical chemistry challenges for Passiflora incarnata (Apigenin) across standard consumer modalities.

💊 Standard Capsules

The hygroscopic nature of concentrated Passiflora extracts requires high-quality moisture barriers or desiccant inclusion to prevent clumping and degradation within HPMC shells.

🍬 Gummy & Pectin Formats

The high concentration of polyphenols can impart a significant astringency and herbal aftertaste that necessitates complex flavor masking and may interfere with pectin gelation kinetics.

🔬 Thin-Film Oral Strips

The relatively high therapeutic dose required for efficacy typically exceeds the standard 50mg payload capacity of most polymer-based thin-film matrices.

For Brand Founders

Formulate with Passiflora incarnata (Apigenin)

Ready to launch a product featuring Passiflora incarnata (Apigenin)? Skip months of expensive wet-lab iterations. Generate a manufacturer-ready formulation in hours, instantly screened for physical incompatibilities and global regulatory compliance.

Build Science-Backed Formulation

Efficacy Evidence

Maximize Passiflora incarnata (Apigenin) Bioavailability

Need absolute proof that your Passiflora incarnata (Apigenin) extract actually absorbs? Stop blindly combining generic powders. Run a physics-based PBPK simulation to mathematically engineer peak clinical efficacy and targeted plasma concentrations.

Simulate Bioavailability

For R&D Labs & CDMOs

Passiflora incarnata (Apigenin) Degradation Testing

Is your Passiflora incarnata (Apigenin) payload degrading in the capsule before the expiration date? Stop waiting for costly bench testing. Run an accelerated digital twin to precisely model oxidation pathways and pH shifts before finalizing a manufacturing run.

Model Active Degradation