Passionflower Extract (Vitexin)

Accelerate your CDMO or DTC pipeline. Map the exact physiochemical constraints, bioavailability synergies, and optimal delivery mechanisms for Passionflower Extract (Vitexin).

Passionflower extract functions as a positive allosteric modulator of GABA-A receptors and a mild monoamine oxidase inhibitor, primarily utilized for its potent anxiolytic and sedative properties in managing sleep-wake cycle disturbances.

Verified Molecular Profiling (NIH PubChem)

PubChem CID

5280441

Molecular Weight

432.4 g/mol

XLogP3 (Lipophilicity)

0.2

IUPAC Name

5,7-dihydroxy-2-(4-hydroxyphenyl)-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one

Pharmacokinetic Synergies & Enhancers

Proven Synergy Pairings

Valerian Root for synergistic GABAergic potentiation through complementary receptor binding sites
L-Theanine for enhanced alpha-wave production and cortisol reduction during the sleep induction phase

Biological Formulation Enhancers

Piperine for inhibition of glucuronidation to increase flavonoid plasma concentration
Quercetin for competitive inhibition of metabolic enzymes to extend biomarker half-life

Delivery System Constraints & Modeling

Every active compound behaves uniquely based on the physical matrix it is suspended in. Below are the known physical chemistry challenges for Passionflower Extract (Vitexin) across standard consumer modalities.

💊 Standard Capsules

The hygroscopic nature of concentrated Passiflora extracts requires moisture-resistant excipients to prevent clumping and ensure long-term stability within HPMC shells.

🍬 Gummy & Pectin Formats

High concentrations of polyphenolic compounds can interfere with pectin cross-linking, potentially resulting in a compromised gel structure or syneresis.

🔬 Thin-Film Oral Strips

The high therapeutic dose required for efficacy often exceeds the 50mg payload capacity of standard thin-film matrices, necessitating high-potency extracts to maintain strip integrity.

For Brand Founders

Formulate with Passionflower Extract (Vitexin)

Ready to launch a product featuring Passionflower Extract (Vitexin)? Skip months of expensive wet-lab iterations. Generate a manufacturer-ready formulation in hours, instantly screened for physical incompatibilities and global regulatory compliance.

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Efficacy Evidence

Maximize Passionflower Extract (Vitexin) Bioavailability

Need absolute proof that your Passionflower Extract (Vitexin) extract actually absorbs? Stop blindly combining generic powders. Run a physics-based PBPK simulation to mathematically engineer peak clinical efficacy and targeted plasma concentrations.

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For R&D Labs & CDMOs

Passionflower Extract (Vitexin) Degradation Testing

Is your Passionflower Extract (Vitexin) payload degrading in the capsule before the expiration date? Stop waiting for costly bench testing. Run an accelerated digital twin to precisely model oxidation pathways and pH shifts before finalizing a manufacturing run.

Model Active Degradation