Phyllanthus niruri (Corilagin)

Accelerate your CDMO or DTC pipeline. Map the exact physiochemical constraints, bioavailability synergies, and optimal delivery mechanisms for Phyllanthus niruri (Corilagin).

Phyllanthus niruri, standardized to the hydrolyzable tannin Corilagin, exerts potent anti-urolithic and hepatoprotective effects by inhibiting calcium oxalate crystallization and modulating the NF-κB and MAPK signaling pathways to reduce oxidative stress.

Verified Molecular Profiling (NIH PubChem)

PubChem CID

73568

Molecular Weight

634.5 g/mol

XLogP3 (Lipophilicity)

0.1

IUPAC Name

[(1S,19R,21S,22R,23R)-6,7,8,11,12,13,22,23-octahydroxy-3,16-dioxo-2,17,20-trioxatetracyclo[17.3.1.04,9.010,15]tricosa-4,6,8,10,12,14-hexaen-21-yl] 3,4,5-trihydroxybenzoate

Pharmacokinetic Synergies & Enhancers

Proven Synergy Pairings

Boerhavia diffusa for synergistic diuretic and renal protective effects in urolithiasis management
Silybum marianum for enhanced hepatoprotective antioxidant activity via synergistic glutathione sparing

Biological Formulation Enhancers

Piperine for increased intestinal permeability and inhibition of hepatic glucuronidation
Phosphatidylcholine for improved micellar transport and bioavailability of the polyphenolic structure

Delivery System Constraints & Modeling

Every active compound behaves uniquely based on the physical matrix it is suspended in. Below are the known physical chemistry challenges for Phyllanthus niruri (Corilagin) across standard consumer modalities.

💊 Standard Capsules

The hygroscopic nature of concentrated Phyllanthus extracts necessitates the use of HPMC capsules and desiccants to maintain powder flowability and prevent hydrolytic degradation of Corilagin.

🍬 Gummy & Pectin Formats

High tannin concentrations in the extract create significant astringency and can interfere with pectin cross-linking, requiring precise pH buffering and advanced flavor masking to ensure consumer acceptance.

🔬 Thin-Film Oral Strips

The relatively high effective dose of Corilagin for clinical applications typically exceeds the limited 30mg payload capacity of standard thin-film polymer matrices.

For Brand Founders

Formulate with Phyllanthus niruri (Corilagin)

Ready to launch a product featuring Phyllanthus niruri (Corilagin)? Skip months of expensive wet-lab iterations. Generate a manufacturer-ready formulation in hours, instantly screened for physical incompatibilities and global regulatory compliance.

Build Science-Backed Formulation

Efficacy Evidence

Maximize Phyllanthus niruri (Corilagin) Bioavailability

Need absolute proof that your Phyllanthus niruri (Corilagin) extract actually absorbs? Stop blindly combining generic powders. Run a physics-based PBPK simulation to mathematically engineer peak clinical efficacy and targeted plasma concentrations.

Simulate Bioavailability

For R&D Labs & CDMOs

Phyllanthus niruri (Corilagin) Degradation Testing

Is your Phyllanthus niruri (Corilagin) payload degrading in the capsule before the expiration date? Stop waiting for costly bench testing. Run an accelerated digital twin to precisely model oxidation pathways and pH shifts before finalizing a manufacturing run.

Model Active Degradation