Phylloquinone (Vitamin K1)

Accelerate your CDMO or DTC pipeline. Map the exact physiochemical constraints, bioavailability synergies, and optimal delivery mechanisms for Phylloquinone (Vitamin K1).

Phylloquinone acts as an essential cofactor for the gamma-glutamyl carboxylase enzyme, facilitating the post-translational modification of vitamin K-dependent proteins critical for blood coagulation cascades and bone mineralization.

Verified Molecular Profiling (NIH PubChem)

PubChem CID

5280483

Molecular Weight

450.7 g/mol

XLogP3 (Lipophilicity)

10.9

IUPAC Name

2-methyl-3-[(E)-3,7,11,15-tetramethylhexadec-2-enyl]naphthalene-1,4-dione

Pharmacokinetic Synergies & Enhancers

Proven Synergy Pairings

Cholecalciferol (Vitamin D3) for synergistic regulation of osteocalcin and calcium homeostasis.
Menaquinone-7 (Vitamin K2) for broader tissue distribution and prolonged half-life in extrahepatic tissues.

Biological Formulation Enhancers

Medium-Chain Triglycerides (MCTs) for enhanced micellar solubilization and lymphatic absorption of this lipophilic molecule.
Quercetin for potential inhibition of P-glycoprotein-mediated efflux in the intestinal epithelium.

Delivery System Constraints & Modeling

Every active compound behaves uniquely based on the physical matrix it is suspended in. Below are the known physical chemistry challenges for Phylloquinone (Vitamin K1) across standard consumer modalities.

💊 Standard Capsules

Phylloquinone is highly sensitive to photo-oxidation and requires opaque capsule shells or antioxidant stabilizers like alpha-tocopherol to prevent degradation during storage.

🍬 Gummy & Pectin Formats

The lipid-soluble nature of phylloquinone necessitates precise emulsification within the pectin or gelatin matrix to prevent oil-spotting and ensure uniform dosage distribution.

🔬 Thin-Film Oral Strips

The high potency and low dosage requirements of phylloquinone suit thin-film formats, though achieving a stable emulsion within the polymer matrix is critical to prevent recrystallization.

For Brand Founders

Formulate with Phylloquinone (Vitamin K1)

Ready to launch a product featuring Phylloquinone (Vitamin K1)? Skip months of expensive wet-lab iterations. Generate a manufacturer-ready formulation in hours, instantly screened for physical incompatibilities and global regulatory compliance.

Build Science-Backed Formulation

Efficacy Evidence

Maximize Phylloquinone (Vitamin K1) Bioavailability

Need absolute proof that your Phylloquinone (Vitamin K1) extract actually absorbs? Stop blindly combining generic powders. Run a physics-based PBPK simulation to mathematically engineer peak clinical efficacy and targeted plasma concentrations.

Simulate Bioavailability

For R&D Labs & CDMOs

Phylloquinone (Vitamin K1) Degradation Testing

Is your Phylloquinone (Vitamin K1) payload degrading in the capsule before the expiration date? Stop waiting for costly bench testing. Run an accelerated digital twin to precisely model oxidation pathways and pH shifts before finalizing a manufacturing run.

Model Active Degradation