Polygonum cuspidatum (Resveratrol)

Accelerate your CDMO or DTC pipeline. Map the exact physiochemical constraints, bioavailability synergies, and optimal delivery mechanisms for Polygonum cuspidatum (Resveratrol).

A stilbenoid polyphenol that modulates sirtuin-1 (SIRT1) activity and AMP-activated protein kinase (AMPK) signaling to enhance mitochondrial biogenesis and provide potent antioxidant protection against oxidative stress-induced cellular senescence.

Verified Molecular Profiling (NIH PubChem)

PubChem CID

445154

Molecular Weight

228.24 g/mol

XLogP3 (Lipophilicity)

3.1

IUPAC Name

5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol

Pharmacokinetic Synergies & Enhancers

Proven Synergy Pairings

Quercetin for inhibition of sulfotransferase and glucuronidase enzymes to increase resveratrol plasma levels
Curcumin for synergistic anti-inflammatory modulation via NF-κB pathway suppression

Biological Formulation Enhancers

Piperine for inhibition of UDP-glucuronosyltransferase to delay metabolic clearance
Lecithin for liposomal encapsulation to improve intestinal permeability and lymphatic transport

Delivery System Constraints & Modeling

Every active compound behaves uniquely based on the physical matrix it is suspended in. Below are the known physical chemistry challenges for Polygonum cuspidatum (Resveratrol) across standard consumer modalities.

💊 Standard Capsules

Resveratrol is highly sensitive to light and oxygen degradation, requiring opaque capsule shells and potentially nitrogen-flushed packaging to maintain potency.

🍬 Gummy & Pectin Formats

The high hydrophobic nature and potential for crystallization can lead to a gritty texture and uneven distribution within the pectin or gelatin matrix.

🔬 Thin-Film Oral Strips

The low aqueous solubility and relatively high therapeutic dose requirements significantly exceed the typical 20-30mg payload capacity of standard thin-film polymers.

For Brand Founders

Formulate with Polygonum cuspidatum (Resveratrol)

Ready to launch a product featuring Polygonum cuspidatum (Resveratrol)? Skip months of expensive wet-lab iterations. Generate a manufacturer-ready formulation in hours, instantly screened for physical incompatibilities and global regulatory compliance.

Build Science-Backed Formulation

Efficacy Evidence

Maximize Polygonum cuspidatum (Resveratrol) Bioavailability

Need absolute proof that your Polygonum cuspidatum (Resveratrol) extract actually absorbs? Stop blindly combining generic powders. Run a physics-based PBPK simulation to mathematically engineer peak clinical efficacy and targeted plasma concentrations.

Simulate Bioavailability

For R&D Labs & CDMOs

Polygonum cuspidatum (Resveratrol) Degradation Testing

Is your Polygonum cuspidatum (Resveratrol) payload degrading in the capsule before the expiration date? Stop waiting for costly bench testing. Run an accelerated digital twin to precisely model oxidation pathways and pH shifts before finalizing a manufacturing run.

Model Active Degradation