Home The Active Ingredient Matrix Polygonum multiflorum (2,3,5,4'-Tetrahydroxystilbene-2-O-beta-D-glucoside)

Formulation Intelligence

Polygonum multiflorum (2,3,5,4'-Tetrahydroxystilbene-2-O-beta-D-glucoside)

Accelerate your CDMO or DTC pipeline. Map the exact physiochemical constraints, bioavailability synergies, and optimal delivery mechanisms for Polygonum multiflorum (2,3,5,4'-Tetrahydroxystilbene-2-O-beta-D-glucoside).

This polyphenolic stilbene glycoside functions as a potent antioxidant and neuroprotective agent by modulating the SIRT1/NF-κB signaling pathway and inhibiting α-synuclein aggregation, primarily targeted for age-related cognitive decline and cardiovascular lipid regulation.

Verified Molecular Profiling (NIH PubChem)

PubChem CID

5318717

Molecular Weight

418.3 g/mol

XLogP3 (Lipophilicity)

1.3

IUPAC Name

3-[(2S,3R,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one

Pharmacokinetic Synergies & Enhancers

Proven Synergy Pairings

  • Resveratrol for synergistic activation of sirtuin pathways and enhanced mitochondrial biogenesis.
  • Panax Ginseng for potentiated neurotrophic effects via BDNF upregulation.

Biological Formulation Enhancers

  • Piperine for inhibition of glucuronidation pathways to increase systemic bioavailability of the stilbene moiety.
  • Quercetin for competitive inhibition of sulfotransferases and P-glycoprotein efflux.

Delivery System Constraints & Modeling

Every active compound behaves uniquely based on the physical matrix it is suspended in. Below are the known physical chemistry challenges for Polygonum multiflorum (2,3,5,4'-Tetrahydroxystilbene-2-O-beta-D-glucoside) across standard consumer modalities.

💊 Standard Capsules

The hygroscopic nature of concentrated Polygonum extracts requires moisture-resistant HPMC capsules and desiccants to prevent clumping and degradation of the stilbene glycoside.

🍬 Gummy & Pectin Formats

The high phenolic content can cause significant oxidative browning and interact with pectin cross-linking, potentially leading to texture instability and a bitter, astringent profile.

🔬 Thin-Film Oral Strips

The high therapeutic dose required for TSG efficacy exceeds the typical 20-30mg payload capacity of thin-film polymers, necessitating complexation with cyclodextrins for taste masking and solubility.

For Brand Founders

Formulate with Polygonum multiflorum (2,3,5,4'-Tetrahydroxystilbene-2-O-beta-D-glucoside)

Ready to launch a product featuring Polygonum multiflorum (2,3,5,4'-Tetrahydroxystilbene-2-O-beta-D-glucoside)? Skip months of expensive wet-lab iterations. Generate a manufacturer-ready formulation in hours, instantly screened for physical incompatibilities and global regulatory compliance.

Build Science-Backed Formulation

Efficacy Evidence

Maximize Polygonum multiflorum (2,3,5,4'-Tetrahydroxystilbene-2-O-beta-D-glucoside) Bioavailability

Need absolute proof that your Polygonum multiflorum (2,3,5,4'-Tetrahydroxystilbene-2-O-beta-D-glucoside) extract actually absorbs? Stop blindly combining generic powders. Run a physics-based PBPK simulation to mathematically engineer peak clinical efficacy and targeted plasma concentrations.

Simulate Bioavailability

For R&D Labs & CDMOs

Polygonum multiflorum (2,3,5,4'-Tetrahydroxystilbene-2-O-beta-D-glucoside) Degradation Testing

Is your Polygonum multiflorum (2,3,5,4'-Tetrahydroxystilbene-2-O-beta-D-glucoside) payload degrading in the capsule before the expiration date? Stop waiting for costly bench testing. Run an accelerated digital twin to precisely model oxidation pathways and pH shifts before finalizing a manufacturing run.

Model Active Degradation