Pullulan

Accelerate your CDMO or DTC pipeline. Map the exact physiochemical constraints, bioavailability synergies, and optimal delivery mechanisms for Pullulan.

Pullulan is a non-ionic, water-soluble extracellular polysaccharide produced by Aureobasidium pullulans, primarily utilized for its film-forming properties and prebiotic potential in modulating gut microbiota and improving glycemic response.

Verified Molecular Profiling (NIH PubChem)

PubChem CID

91852657

Molecular Weight

1456.2 g/mol

XLogP3 (Lipophilicity)

-14.6

IUPAC Name

(2S,3S,4R,5R,6R)-3-[(2R,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(sulfooxymethyl)oxan-2-yl]oxy-6-[(2R,3R,4R,5R,6R)-6-[(2R,3S,4S,5R,6R)-2-carboxy-6-[(2R,3S,4R,5R)-4,6-dihydroxy-5-(sulfoamino)-2-(sulfooxymethyl)oxan-3-yl]oxy-4-hydroxy-5-sulfooxyoxan-3-yl]oxy-5-(sulfoamino)-4-sulfooxy-2-(sulfooxymethyl)oxan-3-yl]oxy-4,5-dihydroxyoxane-2-carboxylic acid

Pharmacokinetic Synergies & Enhancers

Proven Synergy Pairings

Pectin for [Enhanced structural integrity and elasticity in film matrices]
Probiotics for [Synbiotic effects on intestinal microflora proliferation]

Biological Formulation Enhancers

Glycerol for [Plasticization to improve film flexibility and prevent brittleness]
Sorbitol for [Humectant properties to maintain hydration in oral delivery systems]

Delivery System Constraints & Modeling

Every active compound behaves uniquely based on the physical matrix it is suspended in. Below are the known physical chemistry challenges for Pullulan across standard consumer modalities.

💊 Standard Capsules

Pullulan is the gold standard for high-oxygen barrier, non-animal capsules, though it is more sensitive to low humidity environments which can lead to brittleness compared to HPMC.

🍬 Gummy & Pectin Formats

High concentrations of pullulan can significantly increase the viscosity of the pectin or gelatin slurry, potentially leading to premature gelation during the depositing process.

🔬 Thin-Film Oral Strips

As a primary film-former, pullulan provides excellent mechanical strength and rapid dissolution, but high active ingredient loading can compromise the film's tensile strength and clarity.

For Brand Founders

Formulate with Pullulan

Ready to launch a product featuring Pullulan? Skip months of expensive wet-lab iterations. Generate a manufacturer-ready formulation in hours, instantly screened for physical incompatibilities and global regulatory compliance.

Build Science-Backed Formulation

Efficacy Evidence

Maximize Pullulan Bioavailability

Need absolute proof that your Pullulan extract actually absorbs? Stop blindly combining generic powders. Run a physics-based PBPK simulation to mathematically engineer peak clinical efficacy and targeted plasma concentrations.

Simulate Bioavailability

For R&D Labs & CDMOs

Pullulan Degradation Testing

Is your Pullulan payload degrading in the capsule before the expiration date? Stop waiting for costly bench testing. Run an accelerated digital twin to precisely model oxidation pathways and pH shifts before finalizing a manufacturing run.

Model Active Degradation