Rosmarinus officinalis (Carnosic acid)

Accelerate your CDMO or DTC pipeline. Map the exact physiochemical constraints, bioavailability synergies, and optimal delivery mechanisms for Rosmarinus officinalis (Carnosic acid).

Carnosic acid is a lipophilic phenolic diterpene that exerts potent antioxidant and neuroprotective effects by activating the Nrf2/ARE pathway and inhibiting pro-inflammatory cytokines like TNF-α and IL-1β.

Verified Molecular Profiling (NIH PubChem)

PubChem CID

65126

Molecular Weight

332.4 g/mol

XLogP3 (Lipophilicity)

4.9

IUPAC Name

(4aR,10aS)-5,6-dihydroxy-1,1-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthrene-4a-carboxylic acid

Pharmacokinetic Synergies & Enhancers

Proven Synergy Pairings

Curcumin for enhanced anti-inflammatory signaling via dual inhibition of NF-κB
Lutein for synergistic protection against photo-oxidative retinal damage

Biological Formulation Enhancers

Piperine for inhibition of glucuronidation to increase systemic bioavailability
Medium-chain triglycerides (MCTs) for improved micellar solubilization of the lipophilic diterpene structure

Delivery System Constraints & Modeling

Every active compound behaves uniquely based on the physical matrix it is suspended in. Below are the known physical chemistry challenges for Rosmarinus officinalis (Carnosic acid) across standard consumer modalities.

💊 Standard Capsules

The high susceptibility of carnosic acid to oxidative degradation requires the inclusion of an antioxidant stabilizer like ascorbyl palmitate within the dry powder blend.

🍬 Gummy & Pectin Formats

The hydrophobic nature of carnosic acid necessitates pre-emulsification to prevent phase separation and ensure uniform distribution within the hydrophilic pectin or gelatin matrix.

🔬 Thin-Film Oral Strips

The significant bitterness and low aqueous solubility of carnosic acid limit the maximum achievable payload per strip and require advanced taste-masking polymers.

For Brand Founders

Formulate with Rosmarinus officinalis (Carnosic acid)

Ready to launch a product featuring Rosmarinus officinalis (Carnosic acid)? Skip months of expensive wet-lab iterations. Generate a manufacturer-ready formulation in hours, instantly screened for physical incompatibilities and global regulatory compliance.

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Efficacy Evidence

Maximize Rosmarinus officinalis (Carnosic acid) Bioavailability

Need absolute proof that your Rosmarinus officinalis (Carnosic acid) extract actually absorbs? Stop blindly combining generic powders. Run a physics-based PBPK simulation to mathematically engineer peak clinical efficacy and targeted plasma concentrations.

Simulate Bioavailability

For R&D Labs & CDMOs

Rosmarinus officinalis (Carnosic acid) Degradation Testing

Is your Rosmarinus officinalis (Carnosic acid) payload degrading in the capsule before the expiration date? Stop waiting for costly bench testing. Run an accelerated digital twin to precisely model oxidation pathways and pH shifts before finalizing a manufacturing run.

Model Active Degradation