S-Adenosyl-L-methionine (SAMe)

Accelerate your CDMO or DTC pipeline. Map the exact physiochemical constraints, bioavailability synergies, and optimal delivery mechanisms for S-Adenosyl-L-methionine (SAMe).

A critical universal methyl donor involved in the synthesis of neurotransmitters, phospholipids, and DNA, primarily utilized for its antidepressant, hepatoprotective, and chondroprotective properties.

Verified Molecular Profiling (NIH PubChem)

PubChem CID

34755

Molecular Weight

398.4 g/mol

XLogP3 (Lipophilicity)

-2.8

IUPAC Name

(2S)-2-amino-4-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl-methylsulfonio]butanoate

Pharmacokinetic Synergies & Enhancers

Proven Synergy Pairings

Vitamin B12 for homocysteine remethylation
Folate for optimizing the methionine cycle flux

Biological Formulation Enhancers

Enteric coating for protection against gastric acid degradation
Tosylate disulfate salts for improved molecular stability and shelf-life

Delivery System Constraints & Modeling

Every active compound behaves uniquely based on the physical matrix it is suspended in. Below are the known physical chemistry challenges for S-Adenosyl-L-methionine (SAMe) across standard consumer modalities.

💊 Standard Capsules

SAMe is extremely hygroscopic and acid-labile, necessitating enteric-coated capsules or moisture-resistant shells to ensure bioavailability and prevent premature degradation.

🍬 Gummy & Pectin Formats

The high water activity and pH levels in gummy matrices trigger rapid hydrolysis of SAMe, resulting in significant potency loss and the development of sulfurous off-notes.

🔬 Thin-Film Oral Strips

The high therapeutic dose requirements of SAMe far exceed the physical payload capacity of thin-film oral strips, which are typically limited to approximately 50mg of active material.

For Brand Founders

Formulate with S-Adenosyl-L-methionine (SAMe)

Ready to launch a product featuring S-Adenosyl-L-methionine (SAMe)? Skip months of expensive wet-lab iterations. Generate a manufacturer-ready formulation in hours, instantly screened for physical incompatibilities and global regulatory compliance.

Build Science-Backed Formulation

Efficacy Evidence

Maximize S-Adenosyl-L-methionine (SAMe) Bioavailability

Need absolute proof that your S-Adenosyl-L-methionine (SAMe) extract actually absorbs? Stop blindly combining generic powders. Run a physics-based PBPK simulation to mathematically engineer peak clinical efficacy and targeted plasma concentrations.

Simulate Bioavailability

For R&D Labs & CDMOs

S-Adenosyl-L-methionine (SAMe) Degradation Testing

Is your S-Adenosyl-L-methionine (SAMe) payload degrading in the capsule before the expiration date? Stop waiting for costly bench testing. Run an accelerated digital twin to precisely model oxidation pathways and pH shifts before finalizing a manufacturing run.

Model Active Degradation