Solanum nigrum (Solamargine)

Accelerate your CDMO or DTC pipeline. Map the exact physiochemical constraints, bioavailability synergies, and optimal delivery mechanisms for Solanum nigrum (Solamargine).

Solamargine is a steroidal glycoalkaloid that exerts potent antineoplastic activity by inducing apoptosis through the upregulation of TNFRSF1A and TNFRSF1B, while also demonstrating significant hepatoprotective and anti-inflammatory properties.

Verified Molecular Profiling (NIH PubChem)

PubChem CID

73611

Molecular Weight

868.1 g/mol

XLogP3 (Lipophilicity)

1.1

IUPAC Name

(2S,3R,4R,5R,6S)-2-[(2R,3S,4S,5R,6R)-4-hydroxy-2-(hydroxymethyl)-6-[(1S,2S,4S,5'R,6R,7S,8R,9S,12S,13R,16S)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-piperidine]-16-yl]oxy-5-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl]oxy-6-methyloxane-3,4,5-triol

Pharmacokinetic Synergies & Enhancers

Proven Synergy Pairings

Cisplatin for synergistic induction of apoptosis in chemoresistant cell lines
Curcumin for enhanced suppression of NF-κB mediated inflammatory pathways

Biological Formulation Enhancers

Piperine for inhibition of P-glycoprotein mediated efflux to increase intestinal absorption
Quercetin for modulation of CYP3A4 metabolism to extend systemic half-life

Delivery System Constraints & Modeling

Every active compound behaves uniquely based on the physical matrix it is suspended in. Below are the known physical chemistry challenges for Solanum nigrum (Solamargine) across standard consumer modalities.

💊 Standard Capsules

The hygroscopic nature of Solanum nigrum extracts requires moisture-barrier HPMC capsules to prevent clumping and maintain glycoalkaloid stability.

🍬 Gummy & Pectin Formats

The inherent bitterness of steroidal glycoalkaloids necessitates advanced taste-masking agents and high-intensity sweeteners to overcome sensory rejection in pectin-based matrices.

🔬 Thin-Film Oral Strips

Low therapeutic dosage requirements for purified solamargine allow for thin-film integration, though film tensile strength may be compromised by the surfactant properties of the glycoalkaloid.

For Brand Founders

Formulate with Solanum nigrum (Solamargine)

Ready to launch a product featuring Solanum nigrum (Solamargine)? Skip months of expensive wet-lab iterations. Generate a manufacturer-ready formulation in hours, instantly screened for physical incompatibilities and global regulatory compliance.

Build Science-Backed Formulation

Efficacy Evidence

Maximize Solanum nigrum (Solamargine) Bioavailability

Need absolute proof that your Solanum nigrum (Solamargine) extract actually absorbs? Stop blindly combining generic powders. Run a physics-based PBPK simulation to mathematically engineer peak clinical efficacy and targeted plasma concentrations.

Simulate Bioavailability

For R&D Labs & CDMOs

Solanum nigrum (Solamargine) Degradation Testing

Is your Solanum nigrum (Solamargine) payload degrading in the capsule before the expiration date? Stop waiting for costly bench testing. Run an accelerated digital twin to precisely model oxidation pathways and pH shifts before finalizing a manufacturing run.

Model Active Degradation