Sophora flavescens (Matrine)

Accelerate your CDMO or DTC pipeline. Map the exact physiochemical constraints, bioavailability synergies, and optimal delivery mechanisms for Sophora flavescens (Matrine).

A quinolizidine alkaloid that exerts potent anti-inflammatory and hepatoprotective effects by inhibiting the NF-κB signaling pathway and modulating TGF-β/Smad expression to mitigate fibrotic progression.

Verified Molecular Profiling (NIH PubChem)

PubChem CID

91466

Molecular Weight

248.36 g/mol

XLogP3 (Lipophilicity)

1.6

IUPAC Name

(1R,2R,9S,17S)-7,13-diazatetracyclo[7.7.1.02,7.013,17]heptadecan-6-one

Pharmacokinetic Synergies & Enhancers

Proven Synergy Pairings

Glycyrrhizin for synergistic hepatoprotective and anti-inflammatory effects in chronic liver injury
Oxymatrine for enhanced modulation of viral replication and cellular apoptosis

Biological Formulation Enhancers

Piperine for inhibition of P-glycoprotein-mediated efflux to increase systemic bioavailability
Phosphatidylcholine for the formation of phytosomes to improve lipid solubility and intestinal absorption

Delivery System Constraints & Modeling

Every active compound behaves uniquely based on the physical matrix it is suspended in. Below are the known physical chemistry challenges for Sophora flavescens (Matrine) across standard consumer modalities.

💊 Standard Capsules

The hygroscopic nature of Sophora extracts necessitates the use of moisture-resistant HPMC capsules and glidants like silicon dioxide to prevent powder bridging and degradation.

🍬 Gummy & Pectin Formats

The extreme bitterness of matrine alkaloids presents a significant organoleptic challenge, requiring high-intensity sweeteners and potential interference with the pectin cross-linking matrix.

🔬 Thin-Film Oral Strips

The high therapeutic dose required for Matrine typically exceeds the 20-30mg payload capacity of thin-film polymers, making it unsuitable for standard oral strip delivery.

For Brand Founders

Formulate with Sophora flavescens (Matrine)

Ready to launch a product featuring Sophora flavescens (Matrine)? Skip months of expensive wet-lab iterations. Generate a manufacturer-ready formulation in hours, instantly screened for physical incompatibilities and global regulatory compliance.

Build Science-Backed Formulation

Efficacy Evidence

Maximize Sophora flavescens (Matrine) Bioavailability

Need absolute proof that your Sophora flavescens (Matrine) extract actually absorbs? Stop blindly combining generic powders. Run a physics-based PBPK simulation to mathematically engineer peak clinical efficacy and targeted plasma concentrations.

Simulate Bioavailability

For R&D Labs & CDMOs

Sophora flavescens (Matrine) Degradation Testing

Is your Sophora flavescens (Matrine) payload degrading in the capsule before the expiration date? Stop waiting for costly bench testing. Run an accelerated digital twin to precisely model oxidation pathways and pH shifts before finalizing a manufacturing run.

Model Active Degradation