St. John's Wort (Hypericin)

Accelerate your CDMO or DTC pipeline. Map the exact physiochemical constraints, bioavailability synergies, and optimal delivery mechanisms for St. John's Wort (Hypericin).

St. John's Wort extract functions as a broad-spectrum monoamine reuptake inhibitor, primarily modulating serotonin, dopamine, and norepinephrine levels through the inhibition of synaptosomal uptake to alleviate mild-to-moderate depressive symptoms.

Verified Molecular Profiling (NIH PubChem)

PubChem CID

5281023

Molecular Weight

474.6 g/mol

XLogP3 (Lipophilicity)

2.1

IUPAC Name

5-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propylpyrazolo[4,5-d]pyrimidin-7-ol

Pharmacokinetic Synergies & Enhancers

Proven Synergy Pairings

5-HTP for synergistic serotonin synthesis and reuptake inhibition
SAMe for enhanced methyl donor availability in neurotransmitter metabolism

Biological Formulation Enhancers

Piperine for inhibition of P-glycoprotein-mediated efflux
Lecithin for improved micellar solubilization of lipophilic hypericin

Delivery System Constraints & Modeling

Every active compound behaves uniquely based on the physical matrix it is suspended in. Below are the known physical chemistry challenges for St. John's Wort (Hypericin) across standard consumer modalities.

💊 Standard Capsules

The primary formulation constraint involves protecting the extract from photo-oxidation and moisture-induced degradation of hyperforin within the gelatin or HPMC shell.

🍬 Gummy & Pectin Formats

The high acidity required for pectin gelation can accelerate the hydrolytic degradation of hypericin and hyperforin, leading to reduced potency over shelf life.

🔬 Thin-Film Oral Strips

The high therapeutic dosage requirement (typically 300mg per dose) exceeds the standard 50mg payload capacity of thin-film polymer matrices, necessitating multiple strips or concentrated extracts.

For Brand Founders

Formulate with St. John's Wort (Hypericin)

Ready to launch a product featuring St. John's Wort (Hypericin)? Skip months of expensive wet-lab iterations. Generate a manufacturer-ready formulation in hours, instantly screened for physical incompatibilities and global regulatory compliance.

Build Science-Backed Formulation

Efficacy Evidence

Maximize St. John's Wort (Hypericin) Bioavailability

Need absolute proof that your St. John's Wort (Hypericin) extract actually absorbs? Stop blindly combining generic powders. Run a physics-based PBPK simulation to mathematically engineer peak clinical efficacy and targeted plasma concentrations.

Simulate Bioavailability

For R&D Labs & CDMOs

St. John's Wort (Hypericin) Degradation Testing

Is your St. John's Wort (Hypericin) payload degrading in the capsule before the expiration date? Stop waiting for costly bench testing. Run an accelerated digital twin to precisely model oxidation pathways and pH shifts before finalizing a manufacturing run.

Model Active Degradation