Uncaria tomentosa (Mitraphylline)

Accelerate your CDMO or DTC pipeline. Map the exact physiochemical constraints, bioavailability synergies, and optimal delivery mechanisms for Uncaria tomentosa (Mitraphylline).

Mitraphylline acts as a potent immunomodulator and anti-inflammatory agent by inhibiting the NF-κB signaling pathway and modulating the production of pro-inflammatory cytokines such as TNF-α and IL-6.

Verified Molecular Profiling (NIH PubChem)

PubChem CID

441975

Molecular Weight

352.4 g/mol

XLogP3 (Lipophilicity)

2.7

IUPAC Name

methyl (1S,15R,16S,20S)-16-methyl-17-oxa-3,13-diazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-2(10),4,6,8,18-pentaene-19-carboxylate

Pharmacokinetic Synergies & Enhancers

Proven Synergy Pairings

Curcumin for synergistic inhibition of the NF-κB pathway and enhanced anti-arthritic effects.
Quercetin for complementary mast cell stabilization and reduction of systemic oxidative stress.

Biological Formulation Enhancers

Piperine for inhibition of P-glycoprotein-mediated efflux to increase alkaloid bioavailability.
Lecithin for lipid-based micellar solubilization of hydrophobic oxindole alkaloids.

Delivery System Constraints & Modeling

Every active compound behaves uniquely based on the physical matrix it is suspended in. Below are the known physical chemistry challenges for Uncaria tomentosa (Mitraphylline) across standard consumer modalities.

💊 Standard Capsules

The hygroscopic nature of concentrated oxindole alkaloid extracts requires moisture-resistant HPMC shells to prevent clumping and maintain potency.

🍬 Gummy & Pectin Formats

The inherent bitterness of pentacyclic oxindole alkaloids necessitates high-intensity sweeteners and acidulants to mask the astringent profile without compromising pectin gelation.

🔬 Thin-Film Oral Strips

Low payload capacity of thin-film matrices limits the inclusion of full-spectrum extracts, requiring highly purified mitraphylline isolates to achieve therapeutic dosing.

For Brand Founders

Formulate with Uncaria tomentosa (Mitraphylline)

Ready to launch a product featuring Uncaria tomentosa (Mitraphylline)? Skip months of expensive wet-lab iterations. Generate a manufacturer-ready formulation in hours, instantly screened for physical incompatibilities and global regulatory compliance.

Build Science-Backed Formulation

Efficacy Evidence

Maximize Uncaria tomentosa (Mitraphylline) Bioavailability

Need absolute proof that your Uncaria tomentosa (Mitraphylline) extract actually absorbs? Stop blindly combining generic powders. Run a physics-based PBPK simulation to mathematically engineer peak clinical efficacy and targeted plasma concentrations.

Simulate Bioavailability

For R&D Labs & CDMOs

Uncaria tomentosa (Mitraphylline) Degradation Testing

Is your Uncaria tomentosa (Mitraphylline) payload degrading in the capsule before the expiration date? Stop waiting for costly bench testing. Run an accelerated digital twin to precisely model oxidation pathways and pH shifts before finalizing a manufacturing run.

Model Active Degradation