Valerian Root (Valerenic Acid)

Accelerate your CDMO or DTC pipeline. Map the exact physiochemical constraints, bioavailability synergies, and optimal delivery mechanisms for Valerian Root (Valerenic Acid).

Valerian root extract functions primarily as a GABAergic modulator by inhibiting the enzymatic breakdown of gamma-aminobutyric acid via GABA transaminase and acting as a partial agonist at GABA-A receptors to induce anxiolysis and sedative effects.

Verified Molecular Profiling (NIH PubChem)

PubChem CID

6440907

Molecular Weight

795.9 g/mol

XLogP3 (Lipophilicity)

7.5

IUPAC Name

[(9Z,19E,21E)-2,15,17,32-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-28-(propylamino)-8,33-dioxa-27-thia-24,29-diazapentacyclo[23.6.1.14,7.05,31.026,30]tritriaconta-1(31),2,4,9,19,21,25(32),26(30),28-nonaen-13-yl] acetate

Pharmacokinetic Synergies & Enhancers

Proven Synergy Pairings

Hops (Humulus lupulus) for synergistic GABA-A receptor modulation and sedative enhancement.
Lemon Balm (Melissa officinalis) for increased inhibition of GABA transaminase.

Biological Formulation Enhancers

Piperine for potential inhibition of hepatic glucuronidation of sesquiterpenoids.
Lecithin for improved lipophilic micellar solubilization of valerenic acid in the intestinal lumen.

Delivery System Constraints & Modeling

Every active compound behaves uniquely based on the physical matrix it is suspended in. Below are the known physical chemistry challenges for Valerian Root (Valerenic Acid) across standard consumer modalities.

💊 Standard Capsules

The hygroscopic nature and volatile oil content of valerian extract require high-barrier packaging to prevent degradation and the permeation of its characteristic isovaleric acid odor.

🍬 Gummy & Pectin Formats

The potent, pungent organoleptic profile of valerenic acid and volatile oils necessitates complex flavor masking and may interfere with pectin gelation at high concentrations.

🔬 Thin-Film Oral Strips

The high therapeutic dose required for sedative efficacy significantly exceeds the typical 50mg payload capacity of standard thin-film polymer matrices.

For Brand Founders

Formulate with Valerian Root (Valerenic Acid)

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Efficacy Evidence

Maximize Valerian Root (Valerenic Acid) Bioavailability

Need absolute proof that your Valerian Root (Valerenic Acid) extract actually absorbs? Stop blindly combining generic powders. Run a physics-based PBPK simulation to mathematically engineer peak clinical efficacy and targeted plasma concentrations.

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For R&D Labs & CDMOs

Valerian Root (Valerenic Acid) Degradation Testing

Is your Valerian Root (Valerenic Acid) payload degrading in the capsule before the expiration date? Stop waiting for costly bench testing. Run an accelerated digital twin to precisely model oxidation pathways and pH shifts before finalizing a manufacturing run.

Model Active Degradation