Withania somnifera (Withaferin A)

Accelerate your CDMO or DTC pipeline. Map the exact physiochemical constraints, bioavailability synergies, and optimal delivery mechanisms for Withania somnifera (Withaferin A).

Withaferin A, a steroidal lactone derived from Withania somnifera, functions as a potent proteasome inhibitor and modulator of heat shock proteins, primarily utilized for its adaptogenic, anti-inflammatory, and pro-apoptotic properties in oncological and neuroprotective contexts.

Verified Molecular Profiling (NIH PubChem)

PubChem CID

265237

Molecular Weight

470.6 g/mol

XLogP3 (Lipophilicity)

3.8

IUPAC Name

(1S,2R,6S,7R,9R,11S,12S,15R,16S)-6-hydroxy-15-[(1S)-1-[(2R)-5-(hydroxymethyl)-4-methyl-6-oxo-2,3-dihydropyran-2-yl]ethyl]-2,16-dimethyl-8-oxapentacyclo[9.7.0.02,7.07,9.012,16]octadec-4-en-3-one

Pharmacokinetic Synergies & Enhancers

Proven Synergy Pairings

Bacopa monnieri for synergistic cognitive enhancement and BNDF upregulation
L-Theanine for potentiation of GABAergic anxiolytic effects without sedation

Biological Formulation Enhancers

Piperine for inhibition of P-glycoprotein and CYP3A4 mediated metabolism
Phosphatidylcholine for enhanced lipophilic micellar absorption of steroidal lactones

Delivery System Constraints & Modeling

Every active compound behaves uniquely based on the physical matrix it is suspended in. Below are the known physical chemistry challenges for Withania somnifera (Withaferin A) across standard consumer modalities.

💊 Standard Capsules

The hygroscopic nature of concentrated withanolide extracts requires moisture-resistant HPMC shells to prevent clumping and maintain biomarker stability.

🍬 Gummy & Pectin Formats

The inherent bitterness of Withaferin A necessitates high-intensity sweeteners and acidulants to mask the metallic aftertaste which can persist in pectin matrices.

🔬 Thin-Film Oral Strips

The high therapeutic dosage required for standardized extracts often exceeds the 20-30mg payload capacity of standard polymer thin-film matrices.

For Brand Founders

Formulate with Withania somnifera (Withaferin A)

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Efficacy Evidence

Maximize Withania somnifera (Withaferin A) Bioavailability

Need absolute proof that your Withania somnifera (Withaferin A) extract actually absorbs? Stop blindly combining generic powders. Run a physics-based PBPK simulation to mathematically engineer peak clinical efficacy and targeted plasma concentrations.

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For R&D Labs & CDMOs

Withania somnifera (Withaferin A) Degradation Testing

Is your Withania somnifera (Withaferin A) payload degrading in the capsule before the expiration date? Stop waiting for costly bench testing. Run an accelerated digital twin to precisely model oxidation pathways and pH shifts before finalizing a manufacturing run.

Model Active Degradation