Withania somnifera (Withaferin A)

Accelerate your CDMO or DTC pipeline. Map the exact physiochemical constraints, bioavailability synergies, and optimal delivery mechanisms for Withania somnifera (Withaferin A).

Withania somnifera functions as a potent adaptogen by modulating the hypothalamic-pituitary-adrenal (HPA) axis and exerting GABAergic mimetic effects to attenuate cortisol-induced physiological stress responses.

Verified Molecular Profiling (NIH PubChem)

PubChem CID

265237

Molecular Weight

470.6 g/mol

XLogP3 (Lipophilicity)

3.8

IUPAC Name

(1S,2R,6S,7R,9R,11S,12S,15R,16S)-6-hydroxy-15-[(1S)-1-[(2R)-5-(hydroxymethyl)-4-methyl-6-oxo-2,3-dihydropyran-2-yl]ethyl]-2,16-dimethyl-8-oxapentacyclo[9.7.0.02,7.07,9.012,16]octadec-4-en-3-one

Pharmacokinetic Synergies & Enhancers

Proven Synergy Pairings

L-Theanine for synergistic anxiolysis via NMDA receptor modulation
Bacopa monnieri for enhanced long-term potentiation and cognitive resilience

Biological Formulation Enhancers

Piperine for inhibition of glucuronidation to increase systemic exposure
Phosphatidylcholine for the formation of phytosomes to bypass first-pass metabolism

Delivery System Constraints & Modeling

Every active compound behaves uniquely based on the physical matrix it is suspended in. Below are the known physical chemistry challenges for Withania somnifera (Withaferin A) across standard consumer modalities.

💊 Standard Capsules

The high hygroscopicity of standardized withanolide extracts necessitates moisture-barrier HPMC capsules to prevent clumping and degradation.

🍬 Gummy & Pectin Formats

The inherent bitterness and astringency of concentrated withanolides require complex flavor masking and pH adjustment to prevent pectin interference.

🔬 Thin-Film Oral Strips

The typical therapeutic dosage of 300-600mg significantly exceeds the 50mg payload capacity of standard polymer-based thin-film matrices.

For Brand Founders

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Efficacy Evidence

Maximize Withania somnifera (Withaferin A) Bioavailability

Need absolute proof that your Withania somnifera (Withaferin A) extract actually absorbs? Stop blindly combining generic powders. Run a physics-based PBPK simulation to mathematically engineer peak clinical efficacy and targeted plasma concentrations.

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For R&D Labs & CDMOs

Withania somnifera (Withaferin A) Degradation Testing

Is your Withania somnifera (Withaferin A) payload degrading in the capsule before the expiration date? Stop waiting for costly bench testing. Run an accelerated digital twin to precisely model oxidation pathways and pH shifts before finalizing a manufacturing run.

Model Active Degradation