Home The Active Ingredient Matrix Marigold Extract (Zeaxanthin)

Formulation Intelligence

Marigold Extract (Zeaxanthin)

Accelerate your CDMO or DTC pipeline. Map the exact physiochemical constraints, bioavailability synergies, and optimal delivery mechanisms for Marigold Extract (Zeaxanthin).

Zeaxanthin isomers function as potent xanthophyll carotenoids that selectively accumulate in the macula lutea to provide high-energy blue light filtration and neutralize photo-oxidative stress via singlet oxygen quenching.

Verified Molecular Profiling (NIH PubChem)

PubChem CID

5280899

Molecular Weight

568.9 g/mol

XLogP3 (Lipophilicity)

10.9

IUPAC Name

(1R)-4-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-18-[(4R)-4-hydroxy-2,6,6-trimethylcyclohexen-1-yl]-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaenyl]-3,5,5-trimethylcyclohex-3-en-1-ol

Pharmacokinetic Synergies & Enhancers

Proven Synergy Pairings

  • Lutein for complementary macular pigment optical density (MPOD) enhancement
  • Meso-zeaxanthin for full-spectrum foveal protection
  • Docosahexaenoic acid (DHA) for enhanced retinal membrane integration

Biological Formulation Enhancers

  • Lecithin for micellar solubilization of lipophilic carotenoids
  • Piperine for inhibition of first-pass metabolic degradation

Delivery System Constraints & Modeling

Every active compound behaves uniquely based on the physical matrix it is suspended in. Below are the known physical chemistry challenges for Marigold Extract (Zeaxanthin) across standard consumer modalities.

💊 Standard Capsules

The highly unsaturated polyene chain of zeaxanthin necessitates nitrogen flushing or antioxidant inclusion to prevent oxidative degradation within the capsule shell.

🍬 Gummy & Pectin Formats

Zeaxanthin's susceptibility to thermal degradation during the pectin boiling phase requires low-temperature deposition to maintain isomer integrity.

🔬 Thin-Film Oral Strips

The high lipophilicity and required therapeutic dosage of zeaxanthin isomers pose significant challenges for achieving uniform dispersion and adequate payload within a thin-film polymer matrix.

For Brand Founders

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Efficacy Evidence

Maximize Marigold Extract (Zeaxanthin) Bioavailability

Need absolute proof that your Marigold Extract (Zeaxanthin) extract actually absorbs? Stop blindly combining generic powders. Run a physics-based PBPK simulation to mathematically engineer peak clinical efficacy and targeted plasma concentrations.

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For R&D Labs & CDMOs

Marigold Extract (Zeaxanthin) Degradation Testing

Is your Marigold Extract (Zeaxanthin) payload degrading in the capsule before the expiration date? Stop waiting for costly bench testing. Run an accelerated digital twin to precisely model oxidation pathways and pH shifts before finalizing a manufacturing run.

Model Active Degradation